Entity Details

Primary name CDK8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49336
EntryNameCDK8_HUMAN
FullNameCyclin-dependent kinase 8
TaxID9606
Evidenceevidence at protein level
Length464
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCDK8

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006468 protein phosphorylation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0016592 mediator complex
GO:0032991 protein-containing complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB03496 AlvocidibDrugbanksmall molecule

Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
CDK8_HUMANCCNC_HUMANBioGRID, DIP, HPRD, IntAct10024883 10353252 10882111 11416138 11867769 15328539 19047373 19914168 20098423 21806996 23602568 23746844 24981860 25344755 25416956 26186194 26496610 26502155 28514442 29568061 29997244 30695077 7568034 9150135 9710619 details
CDK8_HUMANSMAD1_HUMANBioGRID, IntAct19914168 details
CDK8_HUMANAURKA_HUMANBioGRID, MINT24412244 details
CDK8_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
CDK8_HUMANBUB1_HUMANBioGRID, MINT24412244 details
CDK8_HUMANCCND1_HUMANBioGRID, MINT24412244 details
CDK8_HUMANCADH1_HUMANBioGRID, MINT24412244 details
CDK8_HUMANERBB2_HUMANBioGRID, MINT24412244 details
CDK8_HUMANRASK_HUMANBioGRID, MINT24412244 details
CDK8_HUMANCRCM_HUMANBioGRID, MINT24412244 details
CDK8_HUMANMLH3_HUMANBioGRID, MINT24412244 details
CDK8_HUMANCTDP1_HUMANBioGRID, IntAct19914168 26496610 details
CDK8_HUMANSRBP1_HUMANBioGRID, DIP11834832 16799563 details
CDK8_HUMANCRYA2_HUMANIntAct32814053 details
CDK8_HUMANDYHC1_HUMANIntAct32814053 details
CDK8_HUMANKLK6_HUMANIntAct32814053 details
CDK8_HUMANRPB1_HUMANBioGRID, HPRD11278802 15009212 15328539 22379099 24981860 8700522 9443979 9710619 details
CDK8_HUMANTCEA1_HUMANBioGRID10454562 9305922 details
CDK8_HUMANESR1_HUMANBioGRID11867769 details
CDK8_HUMANESR2_HUMANBioGRID11867769 details
CDK8_HUMANPARP1_HUMANBioGRID15808511 16204234 details
CDK8_HUMANMYC_HUMANBioGRID11673469 details
CDK8_HUMANP53_HUMANBioGRID10024883 details
CDK8_HUMANSMAD2_HUMANBioGRID19914168 details
CDK8_HUMANSMAD3_HUMANBioGRID19914168 details
CDK8_HUMANSMCA4_HUMANBioGRID22668559 details
CDK8_HUMANBCL6_HUMANBioGRID22668559 details
CDK8_HUMANSUZ12_HUMANBioGRID22668559 details
CDK8_HUMANCDK8_HUMANBioGRID15328539 22379099 23322298 23602568 29568061 details
CDK8_HUMANH32_HUMANBioGRID22379099 details
CDK8_HUMANNRIP1_HUMANBioGRID21868449 details
CDK8_HUMANTOP1_HUMANBioGRID12549820 details
CDK8_HUMANMBP_HUMANBioGRID15328539 details
CDK8_HUMANERCC3_HUMANBioGRID10993082 details
CDK8_HUMANCCNH_HUMANBioGRID, HPRD10993082 details
CDK8_HUMANMAML1_HUMANBioGRID, HPRD15546612 details
CDK8_HUMANANM5_HUMANBioGRID23749998 details
CDK8_HUMANMEP50_HUMANBioGRID23749998 details
CDK8_HUMANMED10_HUMANBioGRID, IntAct10024883 10198638 11867769 15175163 15989967 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED19_HUMANBioGRID, IntAct15175163 21729782 23563140 24981860 26186194 28514442 29568061 details
CDK8_HUMANMED9_HUMANBioGRID, HPRD, IntAct14638676 15175163 20098423 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANCDK19_HUMANBioGRID, IntAct15175163 24981860 26186194 28514442 30695077 details
CDK8_HUMANMED14_HUMANBioGRID, DIP, IntAct, MINT10024883 10198638 10882111 11416138 18418385 20098423 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED15_HUMANBioGRID, DIP, IntAct, MINT14657022 18418385 20098423 20720539 23602568 23749998 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED1_HUMANBioGRID, DIP, IntAct, MINT10024883 10198638 10882111 11867769 15989967 18418385 20098423 23322298 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED23_HUMANBioGRID, DIP, IntAct, MINT10353252 11416138 11867769 18418385 20098423 23322298 23602568 25281560 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED17_HUMANBioGRID, DIP, IntAct10198638 10882111 11867769 20098423 23602568 23749998 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED7_HUMANBioGRID, IntAct, MINT10353252 10882111 11867769 23602568 24981860 26186194 28514442 29568061 details
CDK8_HUMANMED21_HUMANBioGRID, HPRD, IntAct, MINT10024883 10198638 10882111 11867769 23602568 24981860 26496610 28514442 29568061 9315662 9710619 details
CDK8_HUMANMED16_HUMANBioGRID, DIP, IntAct10198638 10882111 11867769 20098423 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED13_HUMANBioGRID, DIP, IntAct10198638 10882111 11867769 19047373 20098423 23322298 23602568 23746844 24981860 26186194 26496610 28514442 29568061 30695077 details
CDK8_HUMANMED8_HUMANBioGRID, HPRD, IntAct12584197 23602568 24981860 26186194 26344197 26496610 28514442 29568061 details
CDK8_HUMANMED6_HUMANBioGRID, IntAct10024883 10198638 10882111 11416138 11867769 14983011 15808511 23602568 24981860 26186194 26344197 26496610 28514442 29568061 details
CDK8_HUMANMED20_HUMANBioGRID, IntAct10882111 11867769 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED12_HUMANBioGRID, DIP, HPRD, IntAct, MINT10198638 10882111 11867769 15175163 19047373 20098423 20720539 23322298 23602568 23746844 23749998 24981860 26186194 26496610 27684187 28514442 29568061 30099503 30695077 details
CDK8_HUMANMED22_HUMANBioGRID, IntAct20098423 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED31_HUMANBioGRID, IntAct, MINT10024883 10198638 23602568 24981860 26496610 29568061 details
CDK8_HUMANMED30_HUMANBioGRID, IntAct18691967 23602568 24981860 26186194 26496610 28514442 29568061 details
CDK8_HUMANMED24_HUMANBioGRID, DIP, IntAct10024883 10198638 10882111 11867769 20098423 23322298 23602568 24981860 26186194 26344197 26496610 28514442 29568061 details
CDK8_HUMANMTBP_HUMANBioGRID, IntAct26496610 29568061 30695077 details
CDK8_HUMANE2F1_HUMANDIP18794899 details
CDK8_HUMANMED25_HUMANBioGRID, DIP, HPRD, IntAct14638676 14657022 14983011 20098423 25792360 26186194 26496610 28514442 29568061 details
CDK8_HUMANKAT2B_HUMANBioGRID, IntAct29568061 9710619 details
CDK8_HUMANT2FA_HUMANBioGRID, IntAct29568061 9121429 details
CDK8_HUMANBRCA1_HUMANBioGRID9159119 details
CDK8_HUMANCEBPB_HUMANBioGRID14759369 details
CDK8_HUMANCBP_HUMANBioGRID9710619 details
CDK8_HUMANSNF5_HUMANBioGRID9710619 details
CDK8_HUMANSMRC2_HUMANBioGRID9710619 details
CDK8_HUMANSMRC1_HUMANBioGRID9710619 details
CDK8_HUMANSMCA2_HUMANBioGRID9710619 details
CDK8_HUMANTR150_HUMANBioGRID10198638 details
CDK8_HUMANTHA_HUMANBioGRID10198638 details
CDK8_HUMANEHMT2_HUMANBioGRID18691967 details
CDK8_HUMANSMAD5_HUMANBioGRID19914168 details
CDK8_HUMANSMC1A_HUMANBioGRID20720539 details
CDK8_HUMANSMC3_HUMANBioGRID20720539 details
CDK8_HUMANNIPBL_HUMANBioGRID20720539 details
CDK8_HUMANSTK38_HUMANBioGRID23749998 details
CDK8_HUMANUBP7_HUMANBioGRID27934968 details
CDK8_HUMANTICRR_HUMANBioGRID30695077 details
CDK8_HUMANTOPB1_HUMANBioGRID30695077 details
CDK8_HUMANCDN2B_HUMANHPRD12007796 details