Entity Details

Primary name MAP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50579
EntryNameMAP2_HUMAN
FullNameMethionine aminopeptidase 2
TaxID9606
Evidenceevidence at protein level
Length478
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMETAP2

GO terms

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GOName
GO:0003723 RNA binding
GO:0004177 aminopeptidase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008235 metalloexopeptidase activity
GO:0016485 protein processing
GO:0018206 peptidyl-methionine modification
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0031365 N-terminal protein amino acid modification
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
GO:0070084 protein initiator methionine removal

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000994 Peptidase M24DomainDomain
IPR001714 Peptidase M24, methionine aminopeptidaseFamilyFamily
IPR002468 Peptidase M24A, methionine aminopeptidase, subfamily 2FamilyFamily
IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding siteSiteBinding site
IPR036005 Creatinase/aminopeptidase-likeFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00134 MethionineDrugbanksmall molecule
DB01422 NitroxolineDrugbanksmall molecule
DB02310 3,5,6,8-Tetramethyl-N-Methyl PhenanthroliniumDrugbanksmall molecule
DB02640 FumagillinDrugbanksmall molecule
DB02893 D-MethionineDrugbanksmall molecule
DB03086 N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)HydrazideDrugbanksmall molecule
DB03396 (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamideDrugbanksmall molecule
DB03900 tert-butanolDrugbanksmall molecule
DB04108 (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)AmideDrugbanksmall molecule
DB04324 OvalicinDrugbanksmall molecule
DB05864 PPI-2458Drugbanksmall molecule
DB07309 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACIDDrugbanksmall molecule
DB07313 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACIDDrugbanksmall molecule
DB07322 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACIDDrugbanksmall molecule
DB07323 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACIDDrugbanksmall molecule
DB07377 N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDEDrugbanksmall molecule
DB07746 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACIDDrugbanksmall molecule
DB08633 TNP-470Drugbanksmall molecule