Entity Details

Primary name HMGA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52926
EntryNameHMGA2_HUMAN
FullNameHigh mobility group protein HMGI-C
TaxID9606
Evidenceevidence at protein level
Length109
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesHMGA2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000228 nuclear chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0001837 epithelial to mesenchymal transition
GO:0002062 chondrocyte differentiation
GO:0003131 mesodermal-endodermal cell signaling
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006284 base-excision repair
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007275 multicellular organism development
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0009615 response to virus
GO:0010564 regulation of cell cycle process
GO:0010628 positive regulation of gene expression
GO:0030261 chromosome condensation
GO:0031052 chromosome breakage
GO:0031492 nucleosomal DNA binding
GO:0031507 heterochromatin assembly
GO:0032993 protein-DNA complex
GO:0035497 cAMP response element binding
GO:0035500 MH2 domain binding
GO:0035501 MH1 domain binding
GO:0035978 histone H2A-S139 phosphorylation
GO:0035985 senescence-associated heterochromatin focus
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0035987 endodermal cell differentiation
GO:0035988 chondrocyte proliferation
GO:0040008 regulation of growth
GO:0042769 DNA damage response, detection of DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043922 negative regulation by host of viral transcription
GO:0045444 fat cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048333 mesodermal cell differentiation
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0051301 cell division
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0070742 C2H2 zinc finger domain binding
GO:0071141 SMAD protein complex
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090402 oncogene-induced cell senescence
GO:2000036 regulation of stem cell population maintenance
GO:2000648 positive regulation of stem cell proliferation
GO:2000685 positive regulation of cellular response to X-ray
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038 regulation of cellular response to drug

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000116 High mobility group protein HMGAFamilyFamily
IPR000637 HMG-I/HMG-Y, DNA-binding, conserved siteSiteConserved site
IPR017956 AT hook, DNA-binding motifSiteConserved site

Diseases

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