Entity Details

Primary name PDX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52945
EntryNamePDX1_HUMAN
FullNamePancreas/duodenum homeobox protein 1
TaxID9606
Evidenceevidence at protein level
Length283
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPDX1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0003309 type B pancreatic cell differentiation
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007417 central nervous system development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009887 animal organ morphogenesis
GO:0010040 response to iron(II) ion
GO:0010157 response to chlorate
GO:0010260 animal organ senescence
GO:0010942 positive regulation of cell death
GO:0016331 morphogenesis of embryonic epithelium
GO:0016607 nuclear speck
GO:0030073 insulin secretion
GO:0031017 exocrine pancreas development
GO:0031100 animal organ regeneration
GO:0033273 response to vitamin
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043201 response to leucine
GO:0043279 response to alkaloid
GO:0043388 positive regulation of DNA binding
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048565 digestive tract development
GO:0048863 stem cell differentiation
GO:0051384 response to glucocorticoid
GO:0051594 detection of glucose
GO:0060290 transdifferentiation
GO:0070542 response to fatty acid
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:2000675 negative regulation of type B pancreatic cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR017995 Homeobox protein, antennapedia typeFamilyFamily
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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