Entity Details

Primary name ACLY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53396
EntryNameACLY_HUMAN
FullNameATP-citrate synthase
TaxID9606
Evidenceevidence at protein level
Length1101
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesACLY

GO terms

Show/Hide Table
GOName
GO:0003878 ATP citrate synthase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006085 acetyl-CoA biosynthetic process
GO:0006101 citrate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0016020 membrane
GO:0031325 positive regulation of cellular metabolic process
GO:0035578 azurophil granule lumen
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR002020 Citrate synthaseFamilyFamily
IPR003781 CoA-bindingDomainDomain
IPR005811 ATP-citrate lyase/succinyl-CoA ligaseDomainDomain
IPR014608 ATP-citrate synthaseFamilyFamily
IPR016102 Succinyl-CoA synthetase-likeFamilyHomologous superfamily
IPR016143 Citrate synthase-like, small alpha subdomainFamilyHomologous superfamily
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active siteSiteActive site
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved siteSiteConserved site
IPR032263 ATP-citrate synthase, citrate-binding domainDomainDomain
IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR036969 Citrate synthase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB11936 Bempedoic acidDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
ACLY_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
ACLY_HUMANCUL3_HUMANBioGRID, IntAct21145461 27664236 details
ACLY_HUMANAP2C_HUMANIntAct24835590 details
ACLY_HUMANACLY_HUMANDIP, HPRD10653665 30944472 30944476 31873304 9116495 details
ACLY_HUMANHGS_HUMANBioGRID19019082 details
ACLY_HUMANA4_HUMANBioGRID21832049 details
ACLY_HUMANUBC_HUMANBioGRID17550899 23314748 27182664 details
ACLY_HUMANARF_HUMANBioGRID17955473 details
ACLY_HUMANDDIAS_HUMANBioGRID28079882 details
ACLY_HUMANKLH25_HUMANBioGRID27664236 details
ACLY_HUMANVHL_HUMANIntAct17353931 details
ACLY_HUMANCCNA1_HUMANIntAct17353931 details
ACLY_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct10653665 17353931 30711629 details
ACLY_HUMANTR10D_HUMANIntAct17353931 details
ACLY_HUMANARF6_HUMANIntAct17353931 details
ACLY_HUMANNDKB_HUMANBioGRID, IntAct17353931 27664236 details
ACLY_HUMANBCAR3_HUMANIntAct17353931 details
ACLY_HUMANFXR1_HUMANMINT21653829 details
ACLY_HUMANTERF1_HUMANBioGRID20811636 details
ACLY_HUMANTERF2_HUMANBioGRID20811636 details
ACLY_HUMANHDAC5_HUMANBioGRID21081666 details
ACLY_HUMANISG15_HUMANBioGRID16009940 33024031 details
ACLY_HUMANUBR4_HUMANBioGRID23932781 27664236 details
ACLY_HUMANKAT2B_HUMANBioGRID23932781 details
ACLY_HUMANSIR2_HUMANBioGRID23932781 details
ACLY_HUMANSIR6_HUMANBioGRID24169447 details
ACLY_HUMANUBP13_HUMANBioGRID27892457 details
ACLY_HUMANDERL1_HUMANBioGRID28137758 details
ACLY_HUMANHSP7C_HUMANBioGRID27664236 details
ACLY_HUMANTBB5_HUMANBioGRID27664236 details
ACLY_HUMANIF4A1_HUMANBioGRID27664236 details
ACLY_HUMANSC16A_HUMANBioGRID27664236 details
ACLY_HUMANHNRH1_HUMANBioGRID27664236 details
ACLY_HUMANRS3_HUMANBioGRID27664236 details
ACLY_HUMANTBB3_HUMANBioGRID27664236 details
ACLY_HUMANMCM7_HUMANBioGRID27664236 details
ACLY_HUMANCIC_HUMANBioGRID25277207 details
ACLY_HUMANKAPCA_HUMANHPRD10653665 details