Entity Details

Primary name MOT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53985
EntryNameMOT1_HUMAN
FullNameMonocarboxylate transporter 1
TaxID9606
Evidenceevidence at protein level
Length500
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesSLC16A1

GO terms

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GOName
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006090 pyruvate metabolic process
GO:0006629 lipid metabolic process
GO:0007098 centrosome cycle
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0009925 basal plasma membrane
GO:0015129 lactate transmembrane transporter activity
GO:0015130 mevalonate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015718 monocarboxylic acid transport
GO:0015728 mevalonate transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction
GO:0032094 response to food
GO:0035879 plasma membrane lactate transport
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0046943 carboxylic acid transmembrane transporter activity
GO:0050796 regulation of insulin secretion
GO:0050900 leukocyte migration
GO:0051780 behavioral response to nutrient
GO:0070062 extracellular exosome
GO:0071407 cellular response to organic cyclic compound
GO:0097159 organic cyclic compound binding
GO:0150104 transport across blood-brain barrier
GO:1905039 carboxylic acid transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR004743 Monocarboxylate transporterFamilyFamily
IPR011701 Major facilitator superfamilyFamilyFamily
IPR020846 Major facilitator superfamily domainDomainDomain
IPR030757 Monocarboxylate transporter 1FamilyFamily
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00119 Pyruvic acidDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00175 PravastatinDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00345 Aminohippuric acidSwissprotsmall molecule
DB00415 AmpicillinDrugbanksmall molecule
DB00529 FoscarnetDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00627 NiacinDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00936 Salicylic acidDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01440 gamma-Hydroxybutyric acidDrugbanksmall molecule
DB01762 Acetoacetic acidDrugbanksmall molecule
DB03066 D-Lactic acidDrugbanksmall molecule
DB03166 Acetic acidSwissprotsmall molecule
DB03773 alpha-D-quinovopyranoseDrugbanksmall molecule
DB03793 Benzoic acidDrugbanksmall molecule
DB04074 alpha-KetoisovalerateDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB04398 Lactic acidDrugbanksmall molecule
DB04552 Niflumic acidDrugbanksmall molecule
DB08892 Arbaclofen PlacarbilDrugbanksmall molecule
DB09338 MersalylDrugbanksmall molecule