Entity Details

Primary name CA2D1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54289
EntryNameCA2D1_HUMAN
FullNameVoltage-dependent calcium channel subunit alpha-2/delta-1
TaxID9606
Evidenceevidence at protein level
Length1103
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCACNA2D1

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0016529 sarcoplasmic reticulum
GO:0046872 metal ion binding
GO:0051924 regulation of calcium ion transport
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060402 calcium ion transport into cytosol
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070062 extracellular exosome
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:0098903 regulation of membrane repolarization during action potential
GO:1901843 positive regulation of high voltage-gated calcium channel activity
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1904646 cellular response to amyloid-beta
GO:1990454 L-type voltage-gated calcium channel complex

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002035 von Willebrand factor, type ADomainDomain
IPR013608 VWA N-terminalDomainDomain
IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved regionDomainDomain
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00230 PregabalinDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00308 IbutilideDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00996 GabapentinDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB04838 CyclandelateDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB08872 Gabapentin enacarbilDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule

Interactions

4 interactions