Entity Details

Primary name EPHA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54764
EntryNameEPHA4_HUMAN
FullNameEphrin type-A receptor 4
TaxID9606
Evidenceevidence at protein level
Length986
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA4

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007628 adult walking behavior
GO:0008045 motor neuron axon guidance
GO:0008347 glial cell migration
GO:0009986 cell surface
GO:0010977 negative regulation of neuron projection development
GO:0016301 kinase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021957 corticospinal tract morphogenesis
GO:0030175 filopodium
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0031901 early endosome membrane
GO:0033674 positive regulation of kinase activity
GO:0034332 adherens junction organization
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043507 positive regulation of JUN kinase activity
GO:0043679 axon terminus
GO:0044295 axonal growth cone
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048681 negative regulation of axon regeneration
GO:0048710 regulation of astrocyte differentiation
GO:0050770 regulation of axonogenesis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050821 protein stabilization
GO:0061001 regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0072178 nephric duct morphogenesis
GO:0090102 cochlea development
GO:0097155 fasciculation of sensory neuron axon
GO:0097156 fasciculation of motor neuron axon
GO:0097161 DH domain binding
GO:0097485 neuron projection guidance
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098839 postsynaptic density membrane
GO:0098883 synapse pruning
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0106030 neuron projection fasciculation
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1904646 cellular response to amyloid-beta
GO:1905244 regulation of modification of synaptic structure
GO:1990782 protein tyrosine kinase binding
GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Early endosome

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR030602 Ephrin type-A receptor 4, SAM domainDomainDomain
IPR034270 Ephrin type-A receptor 4, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
EPHA4_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
EPHA4_HUMANEFNB3_HUMANBioGRID, DIP, HPRD, IntAct12383247 23812375 28514442 9484836 details
EPHA4_HUMANEFNB2_HUMANDIP, HPRD12761826 19836338 details
EPHA4_HUMANEFNA2_HUMANDIP19836338 details
EPHA4_HUMANEFNA5_HUMANDIP, HPRD19836338 23812375 8755474 details
EPHA4_HUMANEFNA1_HUMANBioGRID, DIP, HPRD10366629 19836338 8755474 details
EPHA4_HUMANEFNA4_HUMANDIP, HPRD10366629 19836338 details
EPHA4_HUMANEPHA4_HUMANDIP, HPRD23812375 8622893 details
EPHA4_HUMANTENS3_HUMANBioGRID, MINT28065597 details
EPHA4_HUMANNGEF_HUMANBioGRID, HPRD11336673 details
EPHA4_HUMANSRC_HUMANBioGRID9632142 details
EPHA4_HUMANFGFR1_HUMANBioGRID, HPRD16365308 18790757 details
EPHA4_HUMANFGFR3_HUMANBioGRID, HPRD16365308 details
EPHA4_HUMANERBB2_HUMANBioGRID30898150 details
EPHA4_HUMANHS90B_HUMANIntAct22939624 details
EPHA4_HUMANBACH_HUMANIntAct31413325 details
EPHA4_HUMANKCC1B_HUMANIntAct31413325 details
EPHA4_HUMANFYN_HUMANBioGRID, HPRD, IntAct12084815 31413325 details
EPHA4_HUMANZN521_HUMANIntAct31413325 details
EPHA4_HUMANSI1L1_HUMANIntAct31413325 details
EPHA4_HUMANABL2_HUMANIntAct31413325 details
EPHA4_HUMANGLRB_HUMANIntAct31413325 details
EPHA4_HUMANJKIP3_HUMANIntAct31413325 details
EPHA4_HUMANGRB10_HUMANIntAct31413325 details
EPHA4_HUMANMFAP1_HUMANIntAct31413325 details
EPHA4_HUMANTRI37_HUMANIntAct31413325 details
EPHA4_HUMANNUCL_HUMANIntAct31413325 details
EPHA4_HUMANPAX6_HUMANIntAct31413325 details
EPHA4_HUMANVATH_HUMANIntAct31413325 details
EPHA4_HUMANPLCG2_HUMANIntAct31413325 details
EPHA4_HUMANPLCG1_HUMANIntAct31413325 details
EPHA4_HUMANPLAG1_HUMANIntAct31413325 details
EPHA4_HUMANP85A_HUMANIntAct31413325 details
EPHA4_HUMANRASA1_HUMANIntAct31413325 details
EPHA4_HUMANRU17_HUMANIntAct31413325 details
EPHA4_HUMANSTA5B_HUMANIntAct31413325 details
EPHA4_HUMANVAV2_HUMANIntAct31413325 details
EPHA4_HUMANSLBP_HUMANIntAct31413325 details
EPHA4_HUMANRHG39_HUMANIntAct31413325 details
EPHA4_HUMANK1755_HUMANIntAct31413325 details
EPHA4_HUMANLNX1_HUMANIntAct31413325 details
EPHA4_HUMANMB12B_HUMANIntAct31413325 details
EPHA4_HUMANRIMB1_HUMANIntAct31413325 details
EPHA4_HUMANOPALI_HUMANIntAct31413325 details
EPHA4_HUMANNR1D1_HUMANIntAct31413325 details
EPHA4_HUMANGASP1_HUMANIntAct31413325 details
EPHA4_HUMANNR1D2_HUMANIntAct31413325 details
EPHA4_HUMANMAGI2_HUMANIntAct31413325 details
EPHA4_HUMANARHGF_HUMANBioGRID, HPRD12775584 details
EPHA4_HUMANANC2_HUMANBioGRID21186356 details
EPHA4_HUMANFZR1_HUMANBioGRID21186356 details
EPHA4_HUMANFGFR2_HUMANBioGRID16365308 details
EPHA4_HUMANFGFR4_HUMANBioGRID, HPRD16365308 details
EPHA4_HUMANFRS2_HUMANBioGRID16365308 details
EPHA4_HUMANEFNA3_HUMANHPRD12496762 details