Entity Details

Primary name SYMC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56192
EntryNameSYMC_HUMAN
FullNameMethionine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length900
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
GO:0009267 cellular response to starvation
GO:0009303 rRNA transcription
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0032869 cellular response to insulin stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0070062 extracellular exosome
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR014758 Methionyl-tRNA synthetaseFamilyFamily
IPR015413 Methionyl/Leucyl tRNA synthetaseDomainDomain
IPR023458 Methionine-tRNA ligase, type 1FamilyFamily
IPR029038 Methionyl-tRNA synthetase, Zn-domainFamilyHomologous superfamily
IPR033911 Methioninyl-tRNA synthetase core domainDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041598 Methionine--tRNA ligase, N-terminalDomainDomain
IPR041872 Methionyl-tRNA synthetase, anticodon-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00134 MethionineDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
SYMC_HUMANHS90A_HUMANMINT10913161 details
SYMC_HUMANHNRL1_HUMANHPRD, IntAct16169070 details
SYMC_HUMANPPM1F_HUMANHPRD, IntAct16169070 details
SYMC_HUMANCSKP_HUMANBioGRID, IntAct21988832 details
SYMC_HUMANRS27_HUMANBioGRID, MINT21900206 details
SYMC_HUMANTNNT1_HUMANBioGRID, MINT21900206 details
SYMC_HUMANESR1_HUMANBioGRID, IntAct20348541 25604459 31527615 details
SYMC_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
SYMC_HUMANMCA3_HUMANBioGRID, DIP22863883 22939629 24212136 26344197 details
SYMC_HUMANSUMO2_HUMANBioGRID32786267 details
SYMC_HUMANNEMO_HUMANIntAct14743216 details
SYMC_HUMANM3K1_HUMANIntAct14743216 details
SYMC_HUMANM3K3_HUMANIntAct14743216 details
SYMC_HUMANNFKB2_HUMANIntAct14743216 details
SYMC_HUMANTF65_HUMANIntAct14743216 details
SYMC_HUMANWRP73_HUMANIntAct17353931 details
SYMC_HUMANTR10D_HUMANIntAct17353931 details
SYMC_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 29467282 details
SYMC_HUMANTFE3_HUMANIntAct17353931 details
SYMC_HUMANTRAF6_HUMANIntAct17353931 details
SYMC_HUMANHLAB_HUMANIntAct17353931 details
SYMC_HUMANMDM2_HUMANIntAct20195357 details
SYMC_HUMANHDAC5_HUMANBioGRID21081666 details
SYMC_HUMANCDK9_HUMANBioGRID20305087 27684187 details
SYMC_HUMANITA4_HUMANBioGRID22623428 details
SYMC_HUMANEGFR_HUMANBioGRID23956138 details
SYMC_HUMANLENG1_HUMANBioGRID26472760 details
SYMC_HUMANISG15_HUMANBioGRID33024031 details
SYMC_HUMANMAFK_HUMANHPRD9878398 details
SYMC_HUMANMK14_HUMANHPRD9878398 details