Entity Details

Primary name B2MG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61769
EntryNameB2MG_HUMAN
FullNameBeta-2-microglobulin
TaxID9606
Evidenceevidence at protein level
Length119
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesB2M

GO terms

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GOName
GO:0006826 iron ion transport
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0010977 negative regulation of neuron projection development
GO:0050829 defense response to Gram-negative bacterium
GO:0070062 extracellular exosome
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0035580 specific granule lumen
GO:0090647 modulation of age-related behavioral decline
GO:1990000 amyloid fibril formation
GO:0000139 Golgi membrane
GO:0007611 learning or memory
GO:0046686 response to cadmium ion
GO:1900121 negative regulation of receptor binding
GO:0019731 antibacterial humoral response
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050776 regulation of immune response
GO:1904434 positive regulation of ferrous iron binding
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0045087 innate immune response
GO:0052031 modulation by symbiont of host defense response
GO:0003254 regulation of membrane depolarization
GO:0071316 cellular response to nicotine
GO:0005925 focal adhesion
GO:0055038 recycling endosome membrane
GO:0030670 phagocytic vesicle membrane
GO:0042803 protein homodimerization activity
GO:0042824 MHC class I peptide loading complex
GO:0002726 positive regulation of T cell cytokine production
GO:0005576 extracellular region
GO:0001895 retina homeostasis
GO:0012507 ER to Golgi transport vesicle membrane
GO:0033077 T cell differentiation in thymus
GO:0050768 negative regulation of neurogenesis
GO:1904437 positive regulation of transferrin receptor binding
GO:2000774 positive regulation of cellular senescence
GO:0016020 membrane
GO:0034756 regulation of iron ion transport
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071281 cellular response to iron ion
GO:1900122 positive regulation of receptor binding
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0005788 endoplasmic reticulum lumen
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0005829 cytosol
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0045646 regulation of erythrocyte differentiation
GO:0051289 protein homotetramerization
GO:0002237 response to molecule of bacterial origin
GO:0005794 Golgi apparatus
GO:0050690 regulation of defense response to virus by virus
GO:0055072 iron ion homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:1990712 HFE-transferrin receptor complex
GO:0042026 protein refolding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:2000978 negative regulation of forebrain neuron differentiation
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031905 early endosome lumen
GO:0032092 positive regulation of protein binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0009897 external side of plasma membrane
GO:0050830 defense response to Gram-positive bacterium
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0031901 early endosome membrane
GO:0071283 cellular response to iron(III) ion
GO:1904724 tertiary granule lumen

Subcellular Location

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Subcellular Location
Secreted
Cell surface

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015707 Beta-2-MicroglobulinFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02740 3-Indolebutyric AcidDrugbanksmall molecule
DB04464 N-FormylmethionineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11130 OpiumDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
B2MG_HUMANCD1B_HUMANBioGRID, HPRD, IntAct, MINT12118248 14764708 26186194 28514442 details
B2MG_HUMANHLAC_HUMANBioGRID, HPRD, IntAct, MINT10429675 2450918 26186194 27649529 28514442 28546555 details
B2MG_HUMANFCGRN_HUMANBioGRID, HPRD, IntAct, MINT10933786 12006623 28514442 31289263 details
B2MG_HUMANHLAB_HUMANBioGRID, HPRD, IntAct, MINT10975842 11738047 11823531 12244049 17057332 2450918 26186194 27649529 28514442 8624811 8624812 details
B2MG_HUMANHLAA_HUMANBioGRID, HPRD, IntAct, MINT11502003 1448153 20831383 20844028 24163410 26439010 27649529 8805302 93026 details
B2MG_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 details
B2MG_HUMANPRS23_HUMANBioGRID, HPRD, IntAct16169070 details
B2MG_HUMANCD1A_HUMANHPRD, IntAct12833155 15723809 details
B2MG_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
B2MG_HUMANB2MG_HUMANBioGRID, DIP, HPRD, MINT12023961 17108084 18543331 18579777 19172750 19564620 20826442 21131979 21220305 21569201 22289140 22575645 23645685 details
B2MG_HUMANPCOC1_HUMANmatrixdb24117177 details
B2MG_HUMANPCNA_HUMANIntAct, UniProt23527218 26030842 details
B2MG_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
B2MG_HUMANCD1D_HUMANBioGRID, DIP, HPRD10221650 11257307 17581592 details
B2MG_HUMANHMR1_HUMANDIP23051753 details
B2MG_HUMANACM4_HUMANBioGRID, MINT28298427 details
B2MG_HUMANP63_HUMANIntAct12692135 details
B2MG_HUMANPYGO1_HUMANIntAct32814053 details
B2MG_HUMANA2MG_HUMANBioGRID, HPRD10731476 details
B2MG_HUMANCRYAB_HUMANBioGRID23645685 details
B2MG_HUMANCXCR4_HUMANBioGRID18083706 details
B2MG_HUMANHFE_HUMANBioGRID, DIP, HPRD, MINT, UniProt10638746 10791995 15965644 20618438 details
B2MG_HUMANCALR_HUMANBioGRID, HPRD, IntAct25241761 8769474 details
B2MG_HUMANCD244_HUMANIntAct20164429 details
B2MG_HUMANHLAF_HUMANBioGRID, HPRD, IntAct11169396 20483783 26186194 27649529 details
B2MG_HUMANLIRB1_HUMANHPRD, IntAct12897781 27649529 details
B2MG_HUMANCD1E_HUMANBioGRID, HPRD, IntAct10948205 28514442 details
B2MG_HUMANHLAG_HUMANDIP, HPRD, IntAct17056715 18332182 9228302 details
B2MG_HUMANHLAE_HUMANBioGRID, HPRD, IntAct10064069 18332182 9605335 details
B2MG_HUMANTPSN_HUMANBioGRID17055437 details
B2MG_HUMANTAP2_HUMANBioGRID8805302 details
B2MG_HUMANCD8A_HUMANHPRD11914379 details