Entity Details

Primary name ADAM8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78325
EntryNameADAM8_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 8
TaxID9606
Evidenceevidence at protein level
Length824
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesADAM8

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001525 angiogenesis
GO:0002102 podosome
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0002693 positive regulation of cellular extravasation
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0010954 positive regulation of protein processing
GO:0022407 regulation of cell-cell adhesion
GO:0022617 extracellular matrix disassembly
GO:0032010 phagolysosome
GO:0032127 dense core granule membrane
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0035579 specific granule membrane
GO:0042581 specific granule
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043621 protein self-association
GO:0045089 positive regulation of innate immune response
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0048247 lymphocyte chemotaxis
GO:0050714 positive regulation of protein secretion
GO:0050839 cell adhesion molecule binding
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070820 tertiary granule
GO:0070821 tertiary granule membrane
GO:0071133 alpha9-beta1 integrin-ADAM8 complex
GO:0071456 cellular response to hypoxia
GO:0098609 cell-cell adhesion
GO:0101003 ficolin-1-rich granule membrane
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391 positive regulation of neutrophil extravasation
GO:2000415 positive regulation of fibronectin-dependent thymocyte migration
GO:2000418 positive regulation of eosinophil migration

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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