Entity Details

Primary name X3CL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78423
EntryNameX3CL1_HUMAN
FullNameFractalkine
TaxID9606
Evidenceevidence at protein level
Length397
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCX3CL1

GO terms

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GOName
GO:0001774 microglial cell activation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002052 positive regulation of neuroblast proliferation
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002548 monocyte chemotaxis
GO:0002931 response to ischemia
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0008009 chemokine activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016322 neuron remodeling
GO:0019221 cytokine-mediated signaling pathway
GO:0030336 negative regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway
GO:0031737 CX3C chemokine receptor binding
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032690 negative regulation of interleukin-1 alpha production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033622 integrin activation
GO:0035425 autocrine signaling
GO:0042056 chemoattractant activity
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0045237 CXCR1 chemokine receptor binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048020 CCR chemokine receptor binding
GO:0048167 regulation of synaptic plasticity
GO:0048245 eosinophil chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050767 regulation of neurogenesis
GO:0050902 leukocyte adhesive activation
GO:0050918 positive chemotaxis
GO:0051041 positive regulation of calcium-independent cell-cell adhesion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0061518 microglial cell proliferation
GO:0070050 neuron cellular homeostasis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0098609 cell-cell adhesion
GO:0098883 synapse pruning
GO:0110091 negative regulation of hippocampal neuron apoptotic process
GO:1900450 negative regulation of glutamate receptor signaling pathway
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1903979 negative regulation of microglial cell activation
GO:1904141 positive regulation of microglial cell migration
GO:2001223 negative regulation of neuron migration
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR008097 FractalkineFamilyFamily
IPR034127 CX3C chemokine domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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