Entity Details

Primary name PRKDC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78527
EntryNamePRKDC_HUMAN
FullNameDNA-dependent protein kinase catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length4128
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesPRKDC

GO terms

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GOName
GO:0000460 maturation of 5.8S rRNA
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0001756 somitogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002326 B cell lineage commitment
GO:0002328 pro-B cell differentiation
GO:0002360 T cell lineage commitment
GO:0002638 negative regulation of immunoglobulin production
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0014823 response to activity
GO:0016020 membrane
GO:0016233 telomere capping
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031648 protein destabilization
GO:0032040 small-subunit processome
GO:0032481 positive regulation of type I interferon production
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033077 T cell differentiation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0033153 T cell receptor V(D)J recombination
GO:0034462 small-subunit processome assembly
GO:0034511 U3 snoRNA binding
GO:0035234 ectopic germ cell programmed cell death
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048146 positive regulation of fibroblast proliferation
GO:0048511 rhythmic process
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048639 positive regulation of developmental growth
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0070419 nonhomologous end joining complex
GO:0097681 double-strand break repair via alternative nonhomologous end joining
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1905221 positive regulation of platelet formation
GO:2000773 negative regulation of cellular senescence
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
GO:2001229 negative regulation of response to gamma radiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012582 NUC194DomainDomain
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037706 DNA-dependent protein kinase catalytic subunit, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule

Interactions

173 interactions

InteractorPartnerSourcesPublicationsLink
PRKDC_HUMANXRCC6_HUMANBioGRID, HPRD, I2D, IntAct10064605 10446239 10750018 11279128 15520013 17308091 19303849 20711232 21575865 21969602 22939629 26175416 26446488 26496610 28345663 30585729 33005030 8422676 9312071 details
PRKDC_HUMANH2AX_HUMANBioGRID, IntAct14627815 15613478 18406329 20085707 20356835 22184063 26095369 details
PRKDC_HUMANERG_HUMANBioGRID, IntAct21575865 24591637 details
PRKDC_HUMANPPP6_HUMANBioGRID, IntAct20065038 24255178 27684187 28330616 details
PRKDC_HUMANATM_HUMANBioGRID, HPRD10464290 10608806 details
PRKDC_HUMANCHK1_HUMANBioGRID10608806 12756247 details
PRKDC_HUMANRFA2_HUMANBioGRID, HPRD10064605 10713094 11731442 16540648 24332808 8943020 9295339 details
PRKDC_HUMANAKT2_HUMANBioGRID15678105 16221682 details
PRKDC_HUMANCASP3_HUMANBioGRID, HPRD8642305 8804412 details
PRKDC_HUMANSPI1_HUMANIntAct21575865 details
PRKDC_HUMANP53_HUMANBioGRID, HPRD10470151 10601022 10608806 10673501 10713094 10747897 10951572 11551930 11709713 11751391 11883897 12756247 19918261 25362358 8940078 9363941 9679063 9744860 9765199 details
PRKDC_HUMANXRCC5_HUMANBioGRID, DIP, HPRD, I2D, IntAct10207052 10446239 10750018 12393188 15520013 15758953 16857680 17308091 19303849 20023628 20085707 20711232 21679440 22404984 26344197 26446488 26496610 28154079 28345663 33005030 9312071 details
PRKDC_HUMANMKNK1_HUMANBioGRID, IntAct20936779 details
PRKDC_HUMANAP1B1_HUMANBioGRID10608806 details
PRKDC_HUMANWRN_HUMANBioGRID, HPRD10608806 11889123 details
PRKDC_HUMANNCOA6_HUMANBioGRID, HPRD10823961 12519782 details
PRKDC_HUMANPRKDC_HUMANBioGRID, HPRD10750018 10823961 12186630 20065038 25223785 details
PRKDC_HUMANROA1_HUMANBioGRID14704337 details
PRKDC_HUMANGCR_HUMANBioGRID, HPRD9038175 details
PRKDC_HUMANAKT1_HUMANBioGRID, HPRD15262962 15678105 details
PRKDC_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
PRKDC_HUMANNR1H4_HUMANBioGRID, UniProt19833092 details
PRKDC_HUMANDCR1C_HUMANBioGRID, HPRD, IntAct11955432 15456891 15936993 16857680 22529269 31900314 details
PRKDC_HUMANRAD17_HUMANBioGRID10608806 details
PRKDC_HUMANHSF1_HUMANBioGRID, HPRD9325337 details
PRKDC_HUMANSP1_HUMANBioGRID, HPRD8422676 details
PRKDC_HUMANHNRPC_HUMANBioGRID14704337 details
PRKDC_HUMAN4EBP1_HUMANBioGRID10713094 details
PRKDC_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
PRKDC_HUMANMDC1_HUMANBioGRID15377652 details
PRKDC_HUMANCHK2_HUMANBioGRID10713094 17171639 details
PRKDC_HUMANBRCA1_HUMANBioGRID10608806 25223785 details
PRKDC_HUMANNCF1_HUMANBioGRID9914162 details
PRKDC_HUMANR144A_HUMANBioGRID24979766 28450160 30171075 details
PRKDC_HUMANCCNB1_HUMANBioGRID26221070 details
PRKDC_HUMANDNLI4_HUMANBioGRID, HPRD, IntAct10608806 15194694 22529269 details
PRKDC_HUMANCIB1_HUMANBioGRID, HPRD15190070 9372844 details
PRKDC_HUMANHXB7_HUMANBioGRID, IntAct17308091 details
PRKDC_HUMANRFA1_HUMANBioGRID, HPRD10064605 21504906 24332808 details
PRKDC_HUMANMK08_HUMANBioGRID, HPRD11749722 details
PRKDC_HUMANTHA_HUMANBioGRID17242407 details
PRKDC_HUMAN1433T_HUMANBioGRID15161933 20618440 details
PRKDC_HUMANCTIP_HUMANBioGRID10608806 31636387 details
PRKDC_HUMANPP6R3_HUMANBioGRID20065038 details
PRKDC_HUMANSRF_HUMANBioGRID, HPRD8407951 details
PRKDC_HUMANXPA_HUMANBioGRID, DIP, HPRD16540648 20304803 details
PRKDC_HUMANMRE11_HUMANBioGRID10608806 details
PRKDC_HUMANDHX9_HUMANBioGRID15613478 details
PRKDC_HUMANTHB_HUMANBioGRID17242407 details
PRKDC_HUMANHDAC3_HUMANBioGRID17242407 details
PRKDC_HUMANPP6R1_HUMANBioGRID20065038 details
PRKDC_HUMANNBN_HUMANBioGRID, HPRD15758953 details
PRKDC_HUMANEP300_HUMANBioGRID, MINT20808282 30110629 details
PRKDC_HUMANETV1_HUMANIntAct21575865 details
PRKDC_HUMANJUN_HUMANBioGRID, HPRD, MINT25609649 8464713 details
PRKDC_HUMANPP6R2_HUMANBioGRID, IntAct20065038 28514442 details
PRKDC_HUMANPDX1_HUMANBioGRID16166097 details
PRKDC_HUMANC1D_HUMANBioGRID, HPRD9679063 details
PRKDC_HUMANNEMO_HUMANBioGRID, IntAct14743216 31932854 details
PRKDC_HUMANABL1_HUMANBioGRID, HPRD9312071 details
PRKDC_HUMANLYN_HUMANBioGRID, HPRD9748231 details
PRKDC_HUMANNCF4_HUMANBioGRID9914162 details
PRKDC_HUMANXRCC4_HUMANBioGRID, HPRD15194694 15520013 22939629 9259561 9430729 details
PRKDC_HUMANIKKB_HUMANBioGRID9632806 details
PRKDC_HUMANIKKA_HUMANBioGRID, HPRD9632806 details
PRKDC_HUMANPTEN_HUMANBioGRID31685992 details
PRKDC_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
PRKDC_HUMANATRIP_HUMANBioGRID, HPRD15758953 details
PRKDC_HUMANUBC9_HUMANBioGRID19596686 details
PRKDC_HUMANTOP1_HUMANBioGRID, IntAct15848144 28415827 details
PRKDC_HUMANETS1_HUMANIntAct21575865 details
PRKDC_HUMANE4F1_HUMANBioGRID10608806 details
PRKDC_HUMANPRGR_HUMANBioGRID10750018 details
PRKDC_HUMANPO2F1_HUMANBioGRID14612514 17213819 details
PRKDC_HUMANH11_HUMANBioGRID20356835 details
PRKDC_HUMANGSK3B_HUMANBioGRID15678105 details
PRKDC_HUMANRASF1_HUMANBioGRID10608806 details
PRKDC_HUMANCTDP1_HUMANBioGRID21450944 details
PRKDC_HUMANGRAB_HUMANBioGRID, HPRD8760815 9586635 details
PRKDC_HUMANFUMH_HUMANBioGRID26237645 details
PRKDC_HUMANNCF2_HUMANBioGRID9914162 details
PRKDC_HUMANZIC2_HUMANMINT18097573 details
PRKDC_HUMANKAT2A_HUMANBioGRID9488450 details
PRKDC_HUMANMK09_HUMANBioGRID11749722 22366412 details
PRKDC_HUMANDCAF1_HUMANBioGRID22184063 details
PRKDC_HUMANZBT7A_HUMANBioGRID26446488 details
PRKDC_HUMANMBP_HUMANBioGRID15147269 details
PRKDC_HUMANCLK1_HUMANBioGRID26167880 details
PRKDC_HUMANH12_HUMANBioGRID18258596 details
PRKDC_HUMANGSK3A_HUMANBioGRID15678105 details
PRKDC_HUMANAICDA_HUMANBioGRID15634916 details
PRKDC_HUMANM3K3_HUMANIntAct14743216 details
PRKDC_HUMANTF65_HUMANBioGRID, IntAct14743216 25331947 details
PRKDC_HUMANTELO2_HUMANBioGRID, IntAct, UniProt18160036 20427287 20801936 details
PRKDC_HUMANTTI1_HUMANBioGRID, UniProt20371770 20427287 20810650 details
PRKDC_HUMANHS90A_HUMANBioGRID, HPRD16263121 2507541 details
PRKDC_HUMANUBR5_HUMANBioGRID31365120 32867711 details
PRKDC_HUMANIKBE_HUMANIntAct14743216 details
PRKDC_HUMANPARP1_HUMANBioGRID, HPRD, IntAct16794079 20085707 21575865 9398855 details
PRKDC_HUMANH31_HUMANBioGRID, DIP, IntAct20080577 20504901 22404984 26527279 29568061 details
PRKDC_HUMANPCNA_HUMANBioGRID, HPRD12171929 details
PRKDC_HUMANPP2AA_HUMANBioGRID20065038 details
PRKDC_HUMANTRADD_HUMANIntAct14743216 details
PRKDC_HUMANANDR_HUMANBioGRID, IntAct15640154 26175416 details
PRKDC_HUMANITA4_HUMANBioGRID22623428 details
PRKDC_HUMANATOH1_HUMANBioGRID27542412 details
PRKDC_HUMANHMGB1_HUMANHPRD9722660 details
PRKDC_HUMANKPCD_HUMANHPRD, IntAct16611985 9774685 details
PRKDC_HUMANRARA_HUMANIntAct25303530 details
PRKDC_HUMANMGMT_HUMANBioGRID16226712 details
PRKDC_HUMANCAF1A_HUMANBioGRID21209461 details
PRKDC_HUMANCDK9_HUMANBioGRID26209609 27684187 details
PRKDC_HUMANTRI29_HUMANBioGRID26095369 details
PRKDC_HUMANAIRE_HUMANBioGRID, IntAct20085707 details
PRKDC_HUMANCHD1L_HUMANBioGRID, DIP19661379 19666485 details
PRKDC_HUMANFZR1_HUMANBioGRID26221070 details
PRKDC_HUMANHIF1A_HUMANBioGRID15272235 27320910 details
PRKDC_HUMANFLNA_HUMANBioGRID20305393 details
PRKDC_HUMANCDC5L_HUMANBioGRID, MINT11101529 20467437 details
PRKDC_HUMANSIN1_HUMANMolecular Connections24365180 details
PRKDC_HUMANDEAF1_HUMANUniProt22442688 details
PRKDC_HUMANVIGLN_HUMANBioGRID15723802 details
PRKDC_HUMANBMI1_HUMANBioGRID20668194 details
PRKDC_HUMANARHG6_HUMANBioGRID19918261 details
PRKDC_HUMANARAF_HUMANBioGRID29777862 details
PRKDC_HUMANIBP3_HUMANIntAct23178489 details
PRKDC_HUMANRECQ5_HUMANBioGRID19270065 details
PRKDC_HUMANSIR6_HUMANBioGRID20157594 24169447 details
PRKDC_HUMANTERF1_HUMANBioGRID18160036 details
PRKDC_HUMANCSK22_HUMANI2D20711232 details
PRKDC_HUMANMS3L1_HUMANBioGRID20479123 details
PRKDC_HUMAN1433G_HUMANHPRD, MINT15324660 details
PRKDC_HUMANZN840_HUMANIntAct30021884 details
PRKDC_HUMANKAT5_HUMANBioGRID16603769 details
PRKDC_HUMANHXC4_HUMANHPRD11279128 details
PRKDC_HUMANRELB_HUMANIntAct14743216 details
PRKDC_HUMANPNKP_HUMANBioGRID15385968 details
PRKDC_HUMANLOX15_HUMANBioGRID18785202 details
PRKDC_HUMANNKX21_HUMANBioGRID28192407 details
PRKDC_HUMANEGFR_HUMANBioGRID, IntAct23178489 23956138 details
PRKDC_HUMANBIRC5_HUMANBioGRID20394854 details
PRKDC_HUMANMSH6_HUMANBioGRID21075794 details
PRKDC_HUMANAHSA1_HUMANBioGRID22504172 details
PRKDC_HUMANXRCC1_HUMANBioGRID18678286 details
PRKDC_HUMANESR1_HUMANBioGRID, IntAct16794079 21182205 details
PRKDC_HUMANTYY1_HUMANBioGRID, UniProt18026119 details
PRKDC_HUMANLRRK2_HUMANBioGRID, IntAct17400507 19826009 31046837 details
PRKDC_HUMANELP1_HUMANBioGRID18303054 details
PRKDC_HUMANANR55_HUMANBioGRID31620119 details
PRKDC_HUMANRIPK3_HUMANIntAct14743216 details
PRKDC_HUMANILF2_HUMANBioGRID, HPRD, MINT17389650 20808282 9442054 details
PRKDC_HUMANMLH1_HUMANBioGRID17148452 details
PRKDC_HUMANNFKB2_HUMANIntAct14743216 details
PRKDC_HUMANILF3_HUMANBioGRID21969602 9442054 details
PRKDC_HUMANCSK21_HUMANBioGRID22404984 details
PRKDC_HUMANANC2_HUMANBioGRID26221070 details
PRKDC_HUMANSFPQ_HUMANBioGRID30725116 details
PRKDC_HUMANPMS2_HUMANBioGRID17148452 details
PRKDC_HUMANH33_HUMANBioGRID20504901 details
PRKDC_HUMAN1433Z_HUMANMINT15161933 20618440 details
PRKDC_HUMANHDAC5_HUMANBioGRID21081666 details
PRKDC_HUMANUBXN6_HUMANBioGRID22337587 details
PRKDC_HUMANSGO1_HUMANHPRD16541024 details
PRKDC_HUMANKAT8_HUMANBioGRID20479123 details
PRKDC_HUMANTNR1A_HUMANIntAct14743216 details
PRKDC_HUMANISG15_HUMANBioGRID, IntAct26259872 33024031 details
PRKDC_HUMANRUVB2_HUMANBioGRID25875766 details
PRKDC_HUMAN1433B_HUMANMINT15324660 details
PRKDC_HUMANIF2B_HUMANBioGRID, HPRD9442054 details
PRKDC_HUMANHMGB2_HUMANHPRD9722660 details
PRKDC_HUMANTNR1B_HUMANIntAct14743216 details
PRKDC_HUMANAKTIP_HUMANBioGRID27535835 details
PRKDC_HUMANSMRCD_HUMANBioGRID21549307 details