Entity Details

Primary name LRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98164
EntryNameLRP2_HUMAN
FullNameLow-density lipoprotein receptor-related protein 2
TaxID9606
Evidenceevidence at protein level
Length4655
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesLRP2

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003281 ventricular septum development
GO:0005509 calcium ion binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007605 sensory perception of sound
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0009897 external side of plasma membrane
GO:0015031 protein transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0017124 SH3 domain binding
GO:0030001 metal ion transport
GO:0030424 axon
GO:0030425 dendrite
GO:0030514 negative regulation of BMP signaling pathway
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030900 forebrain development
GO:0031526 brush border membrane
GO:0031904 endosome lumen
GO:0031994 insulin-like growth factor I binding
GO:0035904 aorta development
GO:0042359 vitamin D metabolic process
GO:0042562 hormone binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0044321 response to leptin
GO:0045056 transcytosis
GO:0050769 positive regulation of neurogenesis
GO:0051087 chaperone binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060068 vagina development
GO:0060982 coronary artery morphogenesis
GO:0061024 membrane organization
GO:0061156 pulmonary artery morphogenesis
GO:0070062 extracellular exosome
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0071363 cellular response to growth factor stimulus
GO:0097242 amyloid-beta clearance
GO:0140058 neuron projection arborization
GO:0140318 protein transporter activity
GO:0150104 transport across blood-brain barrier
GO:1904447 folate import across plasma membrane
GO:1905167 positive regulation of lysosomal protein catabolic process

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection
Endosome lumen
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR019825 Legume lectin, beta chain, Mn/Ca-binding siteSiteBinding site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00013 UrokinaseDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB00115 CyanocobalaminDrugbanksmall molecule
DB00798 GentamicinDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
LRP2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
LRP2_HUMANABL1_HUMANIntAct17474147 details
LRP2_HUMANDAB2_HUMANBioGRID, HPRD, UniProt10769163 details
LRP2_HUMANAMRP_HUMANBioGRID, HPRD, IntAct11912251 16101684 28514442 7512726 details
LRP2_HUMANDLG3_HUMANBioGRID, HPRD12713445 details
LRP2_HUMANMAGI1_HUMANBioGRID, HPRD11274227 details
LRP2_HUMANANRA2_HUMANBioGRID, HPRD11095640 22649097 details
LRP2_HUMANLR2BP_HUMANBioGRID, HPRD12508107 details
LRP2_HUMANDLG2_HUMANBioGRID, HPRD12713445 details
LRP2_HUMANARH_HUMANBioGRID, HPRD14528014 details
LRP2_HUMANDLG4_HUMANBioGRID, HPRD10827173 12713445 details
LRP2_HUMANJIP1_HUMANBioGRID, HPRD10827173 12508107 details
LRP2_HUMANSYJ2B_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANCAPON_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANSCN3A_HUMANBioGRID10827173 details
LRP2_HUMANAPBA2_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANAPC10_HUMANBioGRID10827173 details
LRP2_HUMANDAB1_HUMANBioGRID, HPRD10827173 12508107 9837937 details
LRP2_HUMANJIP2_HUMANBioGRID, HPRD10827173 12508107 details
LRP2_HUMANITBP1_HUMANBioGRID, HPRD10827173 details
LRP2_HUMANGIPC1_HUMANBioGRID, HPRD10827173 11912251 12508107 16908842 details
LRP2_HUMANANS1B_HUMANBioGRID, HPRD12508107 details
LRP2_HUMANRET1_HUMANBioGRID, HPRD10203351 details
LRP2_HUMANAPOH_HUMANBioGRID, HPRD9727058 details
LRP2_HUMANUTER_HUMANBioGRID, HPRD11278724 details
LRP2_HUMANLIPL_HUMANBioGRID, HPRD7686151 details
LRP2_HUMANUROK_HUMANBioGRID, HPRD8344937 details
LRP2_HUMANCLUS_HUMANBioGRID, HPRD17260971 7768901 9228033 details
LRP2_HUMANAPOE_HUMANBioGRID, HPRD11421580 7768901 details
LRP2_HUMANSNX17_HUMANBioGRID12169628 details
LRP2_HUMANTSP1_HUMANBioGRID7775583 details
LRP2_HUMANA4_HUMANBioGRID9228033 details
LRP2_HUMANRAC1_HUMANBioGRID18426980 details
LRP2_HUMANRHOA_HUMANBioGRID18426980 details
LRP2_HUMANCDC42_HUMANBioGRID18426980 details
LRP2_HUMANTLN1_HUMANHPRD10827173 details
LRP2_HUMANGASP1_HUMANHPRD11274227 details
LRP2_HUMANLRP2_HUMANHPRD11095640 12713445 details
LRP2_HUMANDLG1_HUMANHPRD12713445 details
LRP2_HUMANAPBB1_HUMANHPRD9837937 details
LRP2_HUMANPI51C_HUMANHPRD10827173 details
LRP2_HUMANCTNB1_HUMANIntAct20195357 details
LRP2_HUMANOCRL_HUMANMINT21971085 details
LRP2_HUMANEEA1_HUMANMINT21971085 details
LRP2_HUMANMPRD_HUMANMINT21971085 details
LRP2_HUMANDP13A_HUMANMINT21971085 details
LRP2_HUMANVTDB_HUMANBioGRID, HPRD11717447 details
LRP2_HUMANPAI1_HUMANHPRD8344937 details
LRP2_HUMANTTHY_HUMANHPRD10982792 details
LRP2_HUMANINS_HUMANHPRD9773776 details
LRP2_HUMANAPOB_HUMANHPRD10330424 details
LRP2_HUMANSL9A3_HUMANHPRD10364184 details
LRP2_HUMANTHYG_HUMANHPRD9492085 details
LRP2_HUMANCUBN_HUMANHPRD11595644 11994745 details
LRP2_HUMANNGAL_HUMANHPRD15670845 details
LRP2_HUMANALBU_HUMANHPRD11158855 8898021 details
LRP2_HUMANMK_HUMANHPRD10772929 details