Entity Details

Primary name XIAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP98170
EntryNameXIAP_HUMAN
FullNameE3 ubiquitin-protein ligase XIAP
TaxID9606
Evidenceevidence at protein level
Length497
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesXIAP

GO terms

Show/Hide Table
GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0006974 cellular response to DNA damage stimulus
GO:0016055 Wnt signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045088 regulation of innate immune response
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0055070 copper ion homeostasis
GO:0061630 ubiquitin protein ligase activity
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902530 positive regulation of protein linear polyubiquitination
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001370 BIR repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR042579 XIAP/BIRC8, UBA domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02628 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-AmideDrugbanksmall molecule
DB04209 DequaliniumDrugbanksmall molecule
DB04612 N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDEDrugbanksmall molecule
DB06184 AEG35156Drugbanksmall molecule

Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
XIAP_HUMANCASP7_HUMANBioGRID, HPRD, IntAct, MINT11257230 11257231 11257232 11359776 14512414 15200957 15580265 18521960 19698783 23074197 23979166 27927753 31467278 9230442 9384571 9525868 details
XIAP_HUMANCASP3_HUMANBioGRID, DIP, HPRD, IntAct, MINT11257230 11257232 11359776 11447297 11927604 12624662 15200957 15507451 15650747 16543147 16869888 17069460 17291493 18521960 18723680 19273858 19698783 22072751 22815893 23074197 23979166 25241761 26186194 27927753 28514442 30522111 9230442 9384571 9525868 details
XIAP_HUMANCASP9_HUMANBioGRID, HPRD, IntAct, MINT11242052 11390657 11801603 11927604 12620238 14512414 14523016 15069192 15280366 15300255 15507451 15749826 16189514 16322207 16701639 17179183 17291493 18022362 19153467 19698783 23074197 25241761 25416956 25502805 27107012 29997244 30522111 31467278 31515488 32296183 9545235 details
XIAP_HUMANHTRA2_HUMANBioGRID, HPRD, IntAct, MINT11583623 11602612 11604410 11606597 11801603 11803371 12865429 15201285 15300255 15781261 17906618 24698088 28642151 29631059 31470122 31617661 details
XIAP_HUMANMAGD1_HUMANBioGRID, HPRD, MINT11546791 24947323 details
XIAP_HUMANDBLOH_HUMANBioGRID, DIP, HPRD, IntAct, MINT10929712 11140637 11140638 11242052 11257230 11257231 11602612 11604410 11606597 11801603 12218061 12511567 12525502 12660240 14512414 14523016 15178455 15200957 15280366 15300255 15507451 15541727 15650747 15781261 16282325 17179183 17724022 19153467 19506082 19667203 20957035 21185211 22465666 23251006 23818254 25246529 25801170 27476169 27927753 28514442 29678905 31699976 32447208 32877691 details
XIAP_HUMANNTAQ1_HUMANBioGRID, HPRD, IntAct16189514 27107012 31515488 details
XIAP_HUMANDYL2_HUMANBioGRID, HPRD, IntAct16189514 27173435 31515488 unassigned1312 details
XIAP_HUMANXIAP_HUMANBioGRID, DIP, HPRD, IntAct11175744 11602612 11724934 12048196 16189514 16338389 18570872 19273858 19549727 21113135 22825849 23166698 23259674 24975362 25619915 25801170 27107012 27865841 29053960 30778852 31515488 32788347 details
XIAP_HUMANTBK1_HUMANBioGRID, IntAct16887178 22072751 details
XIAP_HUMANUBC_HUMANBioGRID, MINT17318174 18931663 22194841 23259674 details
XIAP_HUMANNOTC1_HUMANBioGRID, HPRD, MINT17318174 details
XIAP_HUMANUB2D1_HUMANBioGRID, IntAct, MINT12525502 15300255 15749826 17318174 19549727 21113135 22304967 22825849 24975362 29678905 32296183 details
XIAP_HUMANUB2D2_HUMANBioGRID, IntAct11724934 12525502 19549727 21113135 23259674 25801170 27569044 29020630 details
XIAP_HUMANUB2D3_HUMANBioGRID, IntAct12525502 15200957 19549727 21113135 22185822 23818254 32994395 details
XIAP_HUMANUBE2N_HUMANBioGRID, IntAct19549727 details
XIAP_HUMANUB2D4_HUMANBioGRID, IntAct19549727 details
XIAP_HUMANUB2E2_HUMANBioGRID, IntAct19549727 details
XIAP_HUMANUB2V1_HUMANBioGRID, IntAct19549727 25260751 details
XIAP_HUMANUB2V2_HUMANBioGRID, IntAct19549727 details
XIAP_HUMANUBE2W_HUMANBioGRID, IntAct19549727 21113135 details
XIAP_HUMANUB2Q2_HUMANIntAct19549727 details
XIAP_HUMANUB2E1_HUMANBioGRID, IntAct19549727 21113135 details
XIAP_HUMANMDM2_HUMANBioGRID, IntAct19411066 23749209 25888903 details
XIAP_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct12048196 22493164 25241761 details
XIAP_HUMANDTX3_HUMANBioGRID, IntAct22493164 details
XIAP_HUMANTRIM8_HUMANBioGRID, IntAct22493164 details
XIAP_HUMANSEPT4_HUMANBioGRID, IntAct15029247 21185211 21869827 22185822 28224479 29020630 details
XIAP_HUMANRIPK3_HUMANBioGRID, IntAct21931591 details
XIAP_HUMANRIPK2_HUMANBioGRID, DIP, IntAct19667203 21931591 22607974 22815893 23818254 25416956 29452636 30026309 31515488 details
XIAP_HUMANRIPK1_HUMANBioGRID, IntAct21931591 29955050 details
XIAP_HUMANRAC1_HUMANBioGRID, MINT22117219 25301945 26279033 details
XIAP_HUMANRAC3_HUMANMINT22117219 details
XIAP_HUMANRAC2_HUMANMINT22117219 details
XIAP_HUMANRAF1_HUMANBioGRID, IntAct16964381 19011619 25241761 details
XIAP_HUMANBIRC5_HUMANBioGRID, HPRD, Molecular Connections15218035 17613533 21536684 24083380 details
XIAP_HUMANVP37C_HUMANBioGRID, IntAct25416956 31515488 32296183 details
XIAP_HUMANERCC3_HUMANBioGRID, IntAct25416956 31515488 details
XIAP_HUMANRFC5_HUMANBioGRID, IntAct25416956 29892012 31515488 32296183 details
XIAP_HUMANCKS1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
XIAP_HUMANLONF1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
XIAP_HUMANCASPA_HUMANBioGRID, IntAct15069192 25416956 25910212 details
XIAP_HUMANNEK6_HUMANBioGRID, IntAct25416956 31515488 details
XIAP_HUMANADIP_HUMANBioGRID, IntAct25416956 31515488 details
XIAP_HUMANM3K2_HUMANBioGRID, MINT18761086 24975362 details
XIAP_HUMANERF3A_HUMANBioGRID, MINT12865429 26172506 details
XIAP_HUMANPPIH_HUMANBioGRID, IntAct27107012 32296183 details
XIAP_HUMANTAB1_HUMANBioGRID, HPRD, IntAct11865055 12048196 23818254 27107012 28414080 9878061 details
XIAP_HUMANDYN2_HUMANBioGRID, IntAct27107012 details
XIAP_HUMANGOGA2_HUMANBioGRID, IntAct27107012 details
XIAP_HUMANBOLA1_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANPPM1K_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANMTG8_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANSYQ_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANTTC23_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANGCC1_HUMANBioGRID, IntAct32296183 details
XIAP_HUMANNOD1_HUMANBioGRID, DIP19667203 details
XIAP_HUMANNOD2_HUMANBioGRID, DIP, IntAct19667203 22607974 23818254 details
XIAP_HUMANHTRA3_HUMANBioGRID, IntAct28642151 31260151 31470122 details
XIAP_HUMANHTRA1_HUMANBioGRID, IntAct21387310 28642151 details
XIAP_HUMANHTRA4_HUMANIntAct31036715 31470122 details
XIAP_HUMANHEXB_HUMANIntAct32814053 details
XIAP_HUMANPKHN1_HUMANMINT29433439 details
XIAP_HUMANCHK1_HUMANBioGRID, HPRD14759516 details
XIAP_HUMANM3K7_HUMANBioGRID, HPRD11865055 12048196 19584092 details
XIAP_HUMANSTRAB_HUMANBioGRID, HPRD12048196 details
XIAP_HUMANXAF1_HUMANBioGRID, HPRD11175744 17613533 22811387 23323858 33130818 details
XIAP_HUMANSRTD1_HUMANBioGRID19176394 25691055 28656888 details
XIAP_HUMANCHIP_HUMANBioGRID19011619 details
XIAP_HUMANCOMD1_HUMANBioGRID, HPRD14685242 14685266 18795889 details
XIAP_HUMANAIFM1_HUMANBioGRID17967870 22103349 details
XIAP_HUMANUB2J2_HUMANBioGRID19549727 details
XIAP_HUMANUBC9_HUMANBioGRID21113135 details
XIAP_HUMANPTEN_HUMANBioGRID19473982 22427670 details
XIAP_HUMANTRI32_HUMANBioGRID21628460 details
XIAP_HUMANSIVA_HUMANBioGRID19584092 22343716 32015347 details
XIAP_HUMANIKKE_HUMANBioGRID22072751 details
XIAP_HUMANFETA_HUMANBioGRID16869888 details
XIAP_HUMANTCF25_HUMANBioGRID18068114 details
XIAP_HUMANGSK3B_HUMANBioGRID19698783 29678905 details
XIAP_HUMANPGAM5_HUMANBioGRID23201124 details
XIAP_HUMANTCPB_HUMANBioGRID23190606 details
XIAP_HUMANSHIP1_HUMANBioGRID22815893 details
XIAP_HUMANSCAR3_HUMANBioGRID22683311 details
XIAP_HUMANBRCA1_HUMANBioGRID16322207 details
XIAP_HUMANM3K3_HUMANBioGRID24975362 details
XIAP_HUMANTLE3_HUMANBioGRID22304967 29678905 details
XIAP_HUMANTF7L2_HUMANBioGRID22304967 details
XIAP_HUMANFAF1_HUMANBioGRID28414080 details
XIAP_HUMANBCL2_HUMANBioGRID29020630 details
XIAP_HUMANCDK1_HUMANBioGRID27927753 details
XIAP_HUMANCCNB1_HUMANBioGRID27927753 details
XIAP_HUMANCDC42_HUMANBioGRID28661476 details
XIAP_HUMANSQSTM_HUMANBioGRID30275562 details
XIAP_HUMANPHB_HUMANBioGRID27025967 details
XIAP_HUMANHS71A_HUMANBioGRID29255093 details
XIAP_HUMANHS71B_HUMANBioGRID29255093 details
XIAP_HUMANKCNJ6_HUMANBioGRID31011505 details
XIAP_HUMANPIBF1_HUMANBioGRID32296183 details
XIAP_HUMANBOLA2_HUMANBioGRID32296183 details
XIAP_HUMANOGT1_HUMANBioGRID32994395 details
XIAP_HUMANUBP11_HUMANBioGRID, IntAct19615732 28040451 details
XIAP_HUMANSIAH1_HUMANBioGRID, IntAct21185211 details
XIAP_HUMANRIPK4_HUMANIntAct21931591 details
XIAP_HUMANNEDD8_HUMANMINT22584050 details
XIAP_HUMANAKT1_HUMANBioGRID, HPRD, IntAct14645242 23640046 25241761 details
XIAP_HUMANDYL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
XIAP_HUMANBIRC7_HUMANBioGRID, IntAct22711539 26186194 28514442 details
XIAP_HUMANBIRC2_HUMANBioGRID, IntAct16263936 17069460 22711539 28514442 details
XIAP_HUMANCCS_HUMANBioGRID, IntAct20154138 22508683 details
XIAP_HUMANCASP4_HUMANBioGRID11927604 details
XIAP_HUMANTAB2_HUMANBioGRID, HPRD12048196 details
XIAP_HUMANBCL10_HUMANBioGRID16775419 details
XIAP_HUMANUB2L3_HUMANBioGRID12525502 details
XIAP_HUMANEXTL3_HUMANBioGRID12021770 details
XIAP_HUMANBMR1B_HUMANBioGRID19782107 details
XIAP_HUMANBMPR2_HUMANBioGRID19782107 details
XIAP_HUMANTRAF2_HUMANBioGRID19815541 details
XIAP_HUMANHAX1_HUMANBioGRID20171186 details
XIAP_HUMANRB6I2_HUMANBioGRID20932476 details
XIAP_HUMANUBP19_HUMANBioGRID21849505 details
XIAP_HUMANGDIR1_HUMANBioGRID21402697 22532870 details
XIAP_HUMANIRF3_HUMANBioGRID22072751 details
XIAP_HUMANLATS1_HUMANBioGRID16007220 details
XIAP_HUMANBIRC3_HUMANBioGRID17069460 24552816 30948266 details
XIAP_HUMANAPAF_HUMANBioGRID11242052 19698783 details
XIAP_HUMANBAX_HUMANBioGRID21712378 details
XIAP_HUMANHSP74_HUMANBioGRID11606597 details
XIAP_HUMANE2F1_HUMANBioGRID21653699 25216527 details
XIAP_HUMANROA1_HUMANBioGRID17287399 25324306 details
XIAP_HUMANFAIM1_HUMANBioGRID24305822 32015347 details
XIAP_HUMANCASP6_HUMANBioGRID23074197 details
XIAP_HUMANCASP8_HUMANBioGRID15069192 23074197 details
XIAP_HUMANCASPC_HUMANBioGRID23074197 details
XIAP_HUMANCRYAB_HUMANBioGRID23074197 details
XIAP_HUMANIMUP_HUMANBioGRID22886722 details
XIAP_HUMANUB2L6_HUMANBioGRID12525502 details
XIAP_HUMANCDCA4_HUMANBioGRID25691055 details
XIAP_HUMANFAK1_HUMANBioGRID22366087 details
XIAP_HUMANPDCL3_HUMANBioGRID19012568 details
XIAP_HUMANVIME_HUMANBioGRID30778852 details
XIAP_HUMANRN166_HUMANBioGRID33130818 details
XIAP_HUMANACVL1_HUMANHPRD11356828 details
XIAP_HUMANTGFR1_HUMANHPRD11356828 details
XIAP_HUMANUBB_HUMANHPRD15218035 details
XIAP_HUMANAKT2_HUMANHPRD14645242 details