Entity Details

Primary name CLH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00610
EntryNameCLH1_HUMAN
FullNameClathrin heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length1675
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesCLTC

GO terms

Show/Hide Table
GOName
GO:0000278 mitotic cell cycle
GO:0001649 osteoblast differentiation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005198 structural molecule activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0006914 autophagy
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031623 receptor internalization
GO:0032051 clathrin light chain binding
GO:0032588 trans-Golgi network membrane
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032991 protein-containing complex
GO:0033572 transferrin transport
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042147 retrograde transport, endosome to Golgi
GO:0042470 melanosome
GO:0045334 clathrin-coated endocytic vesicle
GO:0048268 clathrin coat assembly
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051301 cell division
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060236 regulation of mitotic spindle organization
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0071439 clathrin complex
GO:0072583 clathrin-dependent endocytosis
GO:0072686 mitotic spindle
GO:0097718 disordered domain specific binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903561 extracellular vesicle
GO:1990381 ubiquitin-specific protease binding
GO:1990498 mitotic spindle microtubule

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Cytoplasmic vesicle membrane
Melanosome
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000547 Clathrin, heavy chain/VPS, 7-fold repeatRepeatRepeat
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR015348 Clathrin, heavy chain, linker, core motifDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016025 Clathrin heavy chain, N-terminalFamilyHomologous superfamily
IPR016341 Clathrin, heavy chainFamilyFamily
IPR022365 Clathrin, heavy chain, propeller repeatRepeatRepeat

Diseases

Show/Hide Table

Interactions

142 interactions

InteractorPartnerSourcesPublicationsLink
CLH1_HUMANXRCC6_HUMANBioGRID, HPRD, IntAct15383276 details
CLH1_HUMANACK1_HUMANBioGRID, HPRD, IntAct, MINT11278436 16137687 19798056 26496610 28739485 details
CLH1_HUMANPAAT_HUMANBioGRID, HPRD, IntAct16169070 26496610 28514442 details
CLH1_HUMANARMX3_HUMANBioGRID, HPRD, IntAct16169070 details
CLH1_HUMANOCRL_HUMANBioGRID, HPRD, IntAct, MINT15917292 16902405 19536138 25107275 26496610 details
CLH1_HUMANARRB1_HUMANBioGRID, HPRD, IntAct, MINT16709866 17620599 24502978 9169477 details
CLH1_HUMANTM1L1_HUMANBioGRID, MINT16412388 17785434 19798056 details
CLH1_HUMANKAPCA_HUMANBioGRID, IntAct20936779 details
CLH1_HUMANCLCA_HUMANBioGRID, HPRD, IntAct, MINT12426379 21297582 2406259 26344197 26496610 30021884 31672988 34079125 details
CLH1_HUMANSYQ_HUMANBioGRID, IntAct21988832 details
CLH1_HUMANEP300_HUMANBioGRID, IntAct21988832 26496610 details
CLH1_HUMANACOC_HUMANBioGRID, IntAct23414517 details
CLH1_HUMANOPTN_HUMANBioGRID, IntAct23414517 details
CLH1_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
CLH1_HUMANHIP1_HUMANBioGRID, HPRD, IntAct11517213 11532990 11604514 11889126 15383276 22820750 23836884 25241761 26496610 details
CLH1_HUMANGCNT1_HUMANUniProt23027862 details
CLH1_HUMANCLCB_HUMANBioGRID, HPRD, IntAct12426379 15533940 21411634 26496610 34079125 details
CLH1_HUMANPICAL_HUMANBioGRID, HPRD, IntAct10436022 26496610 details
CLH1_HUMANAP2B1_HUMANBioGRID, IntAct10748223 17052248 26496610 details
CLH1_HUMANMYO6_HUMANBioGRID, IntAct11447109 26496610 26950368 31672988 details
CLH1_HUMANEPN4_HUMANBioGRID, HPRD, IntAct12429846 12538641 26496610 details
CLH1_HUMANSTABP_HUMANBioGRID, IntAct16431367 16716190 26496610 details
CLH1_HUMANHIP1R_HUMANBioGRID, HPRD, IntAct11889126 26496610 details
CLH1_HUMANAP2A2_HUMANBioGRID, IntAct17052248 26496610 9280305 details
CLH1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
CLH1_HUMANHGS_HUMANBioGRID, HPRD11532964 16716190 21411634 28581508 details
CLH1_HUMANSNX5_HUMANBioGRID15133132 details
CLH1_HUMANTOM1_HUMANBioGRID, HPRD14563850 15657082 16412388 details
CLH1_HUMANAUXI_HUMANBioGRID, HPRD11470803 12732633 33957083 details
CLH1_HUMANEHD1_HUMANBioGRID11423532 26344197 details
CLH1_HUMANGGA1_HUMANBioGRID, HPRD11301005 17052248 17344219 17506864 details
CLH1_HUMANGGA2_HUMANBioGRID, HPRD11301005 11387476 17344219 31076515 details
CLH1_HUMANGGA3_HUMANBioGRID, HPRD11301005 details
CLH1_HUMANAMPH_HUMANBioGRID, HPRD10748223 9195986 9280305 9603201 details
CLH1_HUMANARH_HUMANBioGRID, HPRD12221107 details
CLH1_HUMANAP1B1_HUMANBioGRID, HPRD11451993 9280305 details
CLH1_HUMANAP3B2_HUMANBioGRID, HPRD9545220 details
CLH1_HUMANEPN2_HUMANBioGRID, HPRD10567358 details
CLH1_HUMANVINC_HUMANBioGRID, HPRD8276759 details
CLH1_HUMANSTAM1_HUMANBioGRID16431367 16716190 29604273 details
CLH1_HUMANWNK1_HUMANBioGRID20936779 26496610 details
CLH1_HUMANITSN1_HUMANBioGRID22558309 details
CLH1_HUMANAP1G1_HUMANBioGRID, HPRD11387476 11451993 17052248 21411634 details
CLH1_HUMANHERC1_HUMANBioGRID9233772 details
CLH1_HUMANSYNJ1_HUMANBioGRID12057195 details
CLH1_HUMANSRC_HUMANBioGRID17785434 details
CLH1_HUMANFYN_HUMANBioGRID17785434 details
CLH1_HUMANPP1G_HUMANBioGRID23080069 details
CLH1_HUMANARRB2_HUMANBioGRID, HPRD10097102 17666399 9169477 details
CLH1_HUMANPTAFR_HUMANBioGRID16709866 22707565 details
CLH1_HUMAN1433T_HUMANBioGRID15161933 details
CLH1_HUMANERG_HUMANBioGRID24591637 details
CLH1_HUMANZFYV9_HUMANBioGRID23222715 details
CLH1_HUMANSMAP1_HUMANBioGRID15659652 details
CLH1_HUMANSUMO2_HUMANBioGRID32786267 details
CLH1_HUMANAFTIN_HUMANBioGRID15758025 details
CLH1_HUMANCLH1_HUMANHPRD11532990 12426379 12952949 details
CLH1_HUMANM3K8_HUMANIntAct14743216 details
CLH1_HUMANREL_HUMANIntAct14743216 details
CLH1_HUMANIKBA_HUMANIntAct14743216 details
CLH1_HUMANIKBB_HUMANIntAct14743216 details
CLH1_HUMANIKBE_HUMANIntAct14743216 details
CLH1_HUMANIKKA_HUMANIntAct14743216 details
CLH1_HUMANIKKB_HUMANBioGRID, IntAct14743216 25241761 details
CLH1_HUMANIKKE_HUMANBioGRID, IntAct14743216 17353931 details
CLH1_HUMANNEMO_HUMANIntAct14743216 details
CLH1_HUMANTANK_HUMANIntAct14743216 details
CLH1_HUMANM3K3_HUMANIntAct14743216 details
CLH1_HUMANNFKB2_HUMANIntAct14743216 details
CLH1_HUMANTF65_HUMANIntAct14743216 details
CLH1_HUMANRELB_HUMANIntAct14743216 details
CLH1_HUMANRIPK3_HUMANIntAct14743216 details
CLH1_HUMANTAB2_HUMANIntAct14743216 details
CLH1_HUMANM3K7_HUMANBioGRID, IntAct14743216 25241761 details
CLH1_HUMANTNR1A_HUMANIntAct14743216 details
CLH1_HUMANTNR1B_HUMANIntAct14743216 details
CLH1_HUMANTRADD_HUMANIntAct14743216 details
CLH1_HUMANTRAF2_HUMANIntAct14743216 details
CLH1_HUMANBCR_HUMANMINT15494376 details
CLH1_HUMANHLAC_HUMANIntAct17353931 details
CLH1_HUMANAAKB1_HUMANIntAct17353931 details
CLH1_HUMAN1433Z_HUMANMINT15161933 details
CLH1_HUMANMYB_HUMANMINT18548008 details
CLH1_HUMANGCR_HUMANIntAct20195357 details
CLH1_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 24067654 details
CLH1_HUMANUBC9_HUMANIntAct20936779 details
CLH1_HUMANSF01_HUMANIntAct26420826 details
CLH1_HUMANSCYL2_HUMANBioGRID, HPRD, IntAct1589293 25852190 details
CLH1_HUMANDAB2_HUMANBioGRID, IntAct22323290 26496610 details
CLH1_HUMANSTALP_HUMANBioGRID, IntAct16716190 26496610 28514442 details
CLH1_HUMANEPS15_HUMANBioGRID, IntAct18524853 26496610 details
CLH1_HUMANMARF1_HUMANBioGRID, IntAct26496610 29395067 details
CLH1_HUMANGAK_HUMANBioGRID, HPRD, IntAct12732633 26496610 33957083 details
CLH1_HUMANEPN1_HUMANBioGRID, HPRD, IntAct10692452 26496610 details
CLH1_HUMANADA1A_HUMANIntAct23460120 details
CLH1_HUMANDISC1_HUMANIntAct31413325 details
CLH1_HUMANMIPT3_HUMANIntAct31413325 details
CLH1_HUMANFMR1_HUMANIntAct31413325 details
CLH1_HUMANFAK2_HUMANIntAct31413325 details
CLH1_HUMANPAXI_HUMANBioGRID, HPRD, IntAct10330411 31980649 details
CLH1_HUMANSNX9_HUMANBioGRID, HPRD11799118 12952949 details
CLH1_HUMANKIT_HUMANBioGRID, HPRD10477727 details
CLH1_HUMANM3K10_HUMANBioGRID, HPRD12105200 details
CLH1_HUMANSYUA_HUMANBioGRID18614564 details
CLH1_HUMANHDAC5_HUMANBioGRID21081666 details
CLH1_HUMANRICTR_HUMANBioGRID17461779 details
CLH1_HUMANPCM1_HUMANBioGRID21956701 details
CLH1_HUMANDYR1A_HUMANBioGRID19722700 details
CLH1_HUMANAP180_HUMANBioGRID10748223 details
CLH1_HUMANBIN1_HUMANBioGRID9195986 details
CLH1_HUMANRAC1_HUMANBioGRID21291504 details
CLH1_HUMANTM1L2_HUMANBioGRID16412388 details
CLH1_HUMANISG15_HUMANBioGRID16009940 33024031 details
CLH1_HUMANA16L1_HUMANBioGRID20639872 29360461 30196744 details
CLH1_HUMANAKT1_HUMANBioGRID16027165 details
CLH1_HUMANITA4_HUMANBioGRID22623428 details
CLH1_HUMANMYBB_HUMANBioGRID18548008 details
CLH1_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
CLH1_HUMANATP4A_HUMANBioGRID17255364 details
CLH1_HUMANEPHA2_HUMANBioGRID23874206 details
CLH1_HUMANP53_HUMANBioGRID25144556 29653964 32807901 details
CLH1_HUMANCXB5_HUMANBioGRID25388970 details
CLH1_HUMANADRB2_HUMANBioGRID12163475 23236378 details
CLH1_HUMANV2R_HUMANBioGRID23236378 details
CLH1_HUMANAP3D1_HUMANBioGRID21411634 details
CLH1_HUMANU2AF2_HUMANBioGRID26641092 details
CLH1_HUMANARF6_HUMANBioGRID16413285 details
CLH1_HUMANPGFRB_HUMANBioGRID23836884 details
CLH1_HUMANSTX2_HUMANBioGRID29360461 details
CLH1_HUMANCXA1_HUMANBioGRID24705551 details
CLH1_HUMANANR55_HUMANBioGRID31620119 details
CLH1_HUMANMRP2_HUMANBioGRID31316180 details
CLH1_HUMANKPCB_HUMANBioGRID31634457 details
CLH1_HUMANEPHA3_HUMANBioGRID31577226 details
CLH1_HUMANEIF3H_HUMANBioGRID32269044 details
CLH1_HUMANARRC_HUMANHPRD11877451 9827808 details
CLH1_HUMANNMDE4_HUMANHPRD10862698 details
CLH1_HUMANAP3B1_HUMANHPRD9545220 details
CLH1_HUMANNCALD_HUMANHPRD11964161 details
CLH1_HUMANNMDZ1_HUMANHPRD10862698 details
CLH1_HUMANAP2A_HUMANHPRD1587861 details
CLH1_HUMAN1433G_HUMANHPRD15324660 details