Entity Details

Primary name ANK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01484
EntryNameANK2_HUMAN
FullNameAnkyrin-2
TaxID9606
Evidenceevidence at protein level
Length3957
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesANK2

GO terms

Show/Hide Table
GOName
GO:0002027 regulation of heart rate
GO:0003283 atrial septum development
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0008093 cytoskeletal anchor activity
GO:0010628 positive regulation of gene expression
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 intercalated disc
GO:0015031 protein transport
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030507 spectrin binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031430 M band
GO:0031647 regulation of protein stability
GO:0031672 A band
GO:0033292 T-tubule organization
GO:0033365 protein localization to organelle
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0036309 protein localization to M-band
GO:0036371 protein localization to T-tubule
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043034 costamere
GO:0043268 positive regulation of potassium ion transport
GO:0044325 transmembrane transporter binding
GO:0045211 postsynaptic membrane
GO:0050821 protein stabilization
GO:0051117 ATPase binding
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055037 recycling endosome
GO:0055117 regulation of cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070972 protein localization to endoplasmic reticulum
GO:0072659 protein localization to plasma membrane
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086066 atrial cardiac muscle cell to AV node cell communication
GO:0086070 SA node cell to atrial cardiac muscle cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098907 regulation of SA node cell action potential
GO:0098910 regulation of atrial cardiac muscle cell action potential
GO:0140031 phosphorylation-dependent protein binding
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901021 positive regulation of calcium ion transmembrane transporter activity
GO:2001259 positive regulation of cation channel activity

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Cell junction
Cell membrane
Cytoplasm
Early endosome
Lysosome
Membrane
Mitochondrion
Recycling endosome

Domains

Show/Hide Table
DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000906 ZU5 domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR040745 Ankyrin, UPA domainDomainDomain

Diseases

Show/Hide Table

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ANK2_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
ANK2_HUMANGRB2_HUMANIntAct17474147 details
ANK2_HUMANNCK1_HUMANIntAct17474147 details
ANK2_HUMANP53_HUMANBioGRID, IntAct20195357 details
ANK2_HUMANTAF9_HUMANBioGRID, IntAct20195357 details
ANK2_HUMANGBRL1_HUMANBioGRID, IntAct20562859 29867141 details
ANK2_HUMANGBRL2_HUMANBioGRID, IntAct20562859 29867141 details
ANK2_HUMANANR28_HUMANBioGRID, IntAct23414517 details
ANK2_HUMANDNJB5_HUMANBioGRID, IntAct23414517 details
ANK2_HUMANEHD3_HUMANUniProt20489164 details
ANK2_HUMANNAC1_HUMANDIP16292983 details
ANK2_HUMANKCJ11_HUMANDIP19805355 details
ANK2_HUMANNDEL1_HUMANBioGRID, IntAct17043677 31413325 details
ANK2_HUMANEPB42_HUMANBioGRID2968981 details
ANK2_HUMANGBRAP_HUMANBioGRID29867141 details
ANK2_HUMANMLP3A_HUMANBioGRID29867141 details
ANK2_HUMANMLP3B_HUMANBioGRID29867141 details
ANK2_HUMANMLP3C_HUMANBioGRID29867141 details
ANK2_HUMANSPTB2_HUMANHPRD15262991 details
ANK2_HUMANOBSCN_HUMANHPRD, UniProt12527750 details
ANK2_HUMANDMD_HUMANIntAct19109891 details
ANK2_HUMANDCTN4_HUMANIntAct19109891 details
ANK2_HUMANMTEF1_HUMANIntAct20195357 details
ANK2_HUMANEHD1_HUMANUniProt20489164 details
ANK2_HUMANEHD2_HUMANUniProt20489164 details
ANK2_HUMANEHD4_HUMANUniProt20489164 details
ANK2_HUMANPICAL_HUMANIntAct31413325 details
ANK2_HUMANCTNB1_HUMANBioGRID, MINT31264976 34079125 details
ANK2_HUMANSGMR1_HUMANBioGRID, HPRD11149946 details
ANK2_HUMANABCE1_HUMANBioGRID25659154 details
ANK2_HUMANDNJB1_HUMANBioGRID, HPRD15075330 33957083 details
ANK2_HUMANL1CAM_HUMANHPRD9832558 details
ANK2_HUMANNRCAM_HUMANHPRD11449000 details