Entity Details

Primary name LAT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01650
EntryNameLAT1_HUMAN
FullNameLarge neutral amino acids transporter small subunit 1
TaxID9606
Evidenceevidence at protein level
Length507
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesSLC7A5

GO terms

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GOName
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0010629 negative regulation of gene expression
GO:0015171 amino acid transmembrane transporter activity
GO:0015173 aromatic amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015190 L-leucine transmembrane transporter activity
GO:0015196 L-tryptophan transmembrane transporter activity
GO:0015349 thyroid hormone transmembrane transporter activity
GO:0015804 neutral amino acid transport
GO:0015823 phenylalanine transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042605 peptide antigen binding
GO:0042908 xenobiotic transport
GO:0043231 intracellular membrane-bounded organelle
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070327 thyroid hormone transport
GO:0089718 amino acid import across plasma membrane
GO:0098591 external side of apical plasma membrane
GO:0098713 leucine import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903801 L-leucine import across plasma membrane
GO:1904556 L-tryptophan transmembrane transport
GO:1990184 amino acid transport complex

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR002293 Amino acid/polyamine transporter IFamilyFamily
IPR004760 L-type amino acid transporterFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00130 L-GlutamineDrugbanksmall molecule
DB00230 PregabalinDrugbanksmall molecule
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB00996 GabapentinDrugbanksmall molecule
DB01042 MelphalanSwissprotsmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01746 D-LeucineSwissprotsmall molecule
DB02556 D-PhenylalanineDrugbanksmall molecule
DB02750 S-(Methylmercury)-L-CysteineDrugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech