Entity Details

Primary name PO4F1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01851
EntryNamePO4F1_HUMAN
FullNamePOU domain, class 4, transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length419
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOU4F1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001967 suckling behavior
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003682 chromatin binding
GO:0003697 single-stranded DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0021535 cell migration in hindbrain
GO:0021559 trigeminal nerve development
GO:0021953 central nervous system neuron differentiation
GO:0021986 habenula development
GO:0031175 neuron projection development
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043069 negative regulation of programmed cell death
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048665 neuron fate specification
GO:0048880 sensory system development
GO:0048935 peripheral nervous system neuron development
GO:0050767 regulation of neurogenesis
GO:0051020 GTPase binding
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051355 proprioception involved in equilibrioception
GO:0060384 innervation
GO:0071345 cellular response to cytokine stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090575 RNA polymerase II transcription regulator complex
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001208 negative regulation of transcription elongation by RNA polymerase I

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR001387 Cro/C1-type helix-turn-helix domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR015584 POU domain, class 4, transcription factor 1FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PO4F1_HUMANMARE3_HUMANBioGRID, IntAct32296183 details
PO4F1_HUMANRIT2_HUMANBioGRID, HPRD12934100 details
PO4F1_HUMANESR1_HUMANBioGRID, HPRD9448000 details
PO4F1_HUMANEWS_HUMANBioGRID, HPRD12432261 details