Entity Details

Primary name MEF2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02078
EntryNameMEF2A_HUMAN
FullNameMyocyte-specific enhancer factor 2A
TaxID9606
Evidenceevidence at protein level
Length507
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMEF2A

GO terms

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GOName
GO:0000002 mitochondrial genome maintenance
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0048311 mitochondrion distribution
GO:0048813 dendrite morphogenesis
GO:0051149 positive regulation of muscle cell differentiation
GO:0055005 ventricular cardiac myofibril assembly
GO:0061337 cardiac conduction
GO:0070375 ERK5 cascade
GO:0071277 cellular response to calcium ion

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002100 Transcription factor, MADS-boxDomainDomain
IPR022102 Holliday junction regulator protein family C-terminalDomainDomain
IPR033896 MADS MEF2-likeDomainDomain
IPR036879 Transcription factor, MADS-box superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608320 OMIMCoronary artery disease, autosomal dominant, 1 (ADCAD1)A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction. The disease is caused by variants affecting the gene represented in this entry.

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
MEF2A_HUMANHDAC4_HUMANBioGRID, HPRD, IntAct, MINT10487761 10748098 11792813 19389706 32296183 details
MEF2A_HUMANSUMO1_HUMANDIP, HPRD, MINT16484498 17036045 19684601 details
MEF2A_HUMANDDB1_HUMANBioGRID, IntAct21988832 details
MEF2A_HUMANNDUB9_HUMANBioGRID, IntAct21988832 details
MEF2A_HUMANPITX2_HUMANbhf-ucl15466416 details
MEF2A_HUMANHDAC5_HUMANBioGRID, HPRD, MINT10737771 10748098 12626519 22308472 25609649 details
MEF2A_HUMANMEOX1_HUMANBioGRID, IntAct26871637 details
MEF2A_HUMANMK07_HUMANBioGRID, HPRD, IntAct10849446 26871637 9753748 9858528 details
MEF2A_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
MEF2A_HUMANUBC9_HUMANBioGRID, DIP19684601 details
MEF2A_HUMANVGLL4_HUMANBioGRID15140898 details
MEF2A_HUMANHDAC9_HUMANBioGRID, HPRD10487761 10748098 10825153 details
MEF2A_HUMANTHA_HUMANBioGRID, HPRD12371907 details
MEF2A_HUMANEP300_HUMANBioGRID, HPRD12371907 20590529 details
MEF2A_HUMANSMAD2_HUMANBioGRID, HPRD11160896 details
MEF2A_HUMANMK14_HUMANBioGRID, HPRD10330143 10849446 9858528 details
MEF2A_HUMANASCL1_HUMANBioGRID, HPRD8662987 8900141 details
MEF2A_HUMANMYOG_HUMANBioGRID, HPRD1329097 details
MEF2A_HUMANACTN4_HUMANBioGRID16980305 details
MEF2A_HUMANHDAC7_HUMANBioGRID16956611 16980305 20590529 22308472 details
MEF2A_HUMANERBIN_HUMANBioGRID15123239 details
MEF2A_HUMANHAND1_HUMANBioGRID16043483 details
MEF2A_HUMANDNM3L_HUMANBioGRID24952347 details
MEF2A_HUMANMEF2A_HUMANHPRD, MINT25609649 8575763 details
MEF2A_HUMANMEF2D_HUMANBioGRID, HPRD, MINT20590529 25609649 8798771 9858528 details
MEF2A_HUMANSUMO2_HUMANDIP19684601 details
MEF2A_HUMANHDAC1_HUMANBioGRID20590529 details
MEF2A_HUMANPHB2_HUMANBioGRID, HPRD15173318 details
MEF2A_HUMANGBB2_HUMANBioGRID23326349 details
MEF2A_HUMANGBG12_HUMANBioGRID23326349 details
MEF2A_HUMANTBP_HUMANBioGRID23326349 details
MEF2A_HUMANTAF8_HUMANBioGRID23326349 details
MEF2A_HUMANHDAC3_HUMANBioGRID22308472 details
MEF2A_HUMANTEAD1_HUMANHPRD12061776 12861002 details
MEF2A_HUMANCASP3_HUMANHPRD11904443 details
MEF2A_HUMANCASP7_HUMANHPRD11904443 details
MEF2A_HUMANSMAD4_HUMANHPRD11160896 details
MEF2A_HUMANCDK5_HUMANHPRD12691662 details
MEF2A_HUMANMYOD1_HUMANHPRD8548800 9418854 details