Entity Details

Primary name CENPE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02224
EntryNameCENPE_HUMAN
FullNameCentromere-associated protein E
TaxID9606
Evidenceevidence at protein level
Length2701
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesCENPE

GO terms

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GOName
GO:0000278 mitotic cell cycle
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000779 condensed chromosome, centromeric region
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005828 kinetochore microtubule
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007079 mitotic chromosome movement towards spindle pole
GO:0007080 mitotic metaphase plate congression
GO:0007275 multicellular organism development
GO:0008017 microtubule binding
GO:0008574 plus-end-directed microtubule motor activity
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0030496 midbody
GO:0043515 kinetochore binding
GO:0045860 positive regulation of protein kinase activity
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0051310 metaphase plate congression
GO:0051315 attachment of mitotic spindle microtubules to kinetochore
GO:0051382 kinetochore assembly
GO:0099606 microtubule plus-end directed mitotic chromosome migration
GO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore
GO:1990023 mitotic spindle midzone

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm

Domains

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DomainNameCategoryType
IPR001752 Kinesin motor domainDomainDomain
IPR019821 Kinesin motor domain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06097 GSK-923295Drugbanksmall molecule