Entity Details

Primary name MP2K1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02750
EntryNameMP2K1_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 1
TaxID9606
Evidenceevidence at protein level
Length393
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0018107 peptidyl-threonine phosphorylation
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030878 thyroid gland development
GO:0032872 regulation of stress-activated MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB03115 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideDrugbanksmall molecule
DB05239 CobimetinibDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB06892 (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamideDrugbanksmall molecule
DB07046 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamideDrugbanksmall molecule
DB07101 PD-0325901Drugbanksmall molecule
DB08130 N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamineDrugbanksmall molecule
DB08208 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDEDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
MP2K1_HUMANMK01_HUMANBioGRID, HPRD, MINT10757792 11134045 11266467 11279118 11352917 11741894 11823456 12594221 12697810 12788955 17255949 19058874 21336309 21675959 23241949 24623782 27884160 8157000 details
MP2K1_HUMANBRAF_HUMANBioGRID, DIP, HPRD, IntAct16810323 16888650 17979178 18332145 19371126 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27034005 27684187 28514442 31015455 31980649 7731720 8157000 8394352 8621729 9733801 details
MP2K1_HUMANRAF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10757792 10958680 11604401 15485920 15866172 16093354 17724343 17979178 18556463 19058874 19197339 20212043 21336309 23934108 24746704 25155755 26496610 27703006 31980649 7527398 7731720 8157000 8394352 8621729 9311917 9733801 details
MP2K1_HUMANARAF_HUMANBioGRID, HPRD, IntAct17979178 24114843 24746704 26496610 31980649 7731720 8157000 8394352 8621729 details
MP2K1_HUMANDCOR_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANJIP3_HUMANBioGRID, HPRD10523642 11044439 details
MP2K1_HUMANMK03_HUMANBioGRID, HPRD, MINT10748187 19058874 19197339 8226933 8626767 9006895 9733512 details
MP2K1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBANP_HUMANBioGRID, IntAct25416956 32296183 details
MP2K1_HUMANGRB10_HUMANBioGRID, HPRD9553107 details
MP2K1_HUMANMP2K1_HUMANBioGRID, HPRD12697810 17979178 31980649 8226933 9733512 details
MP2K1_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPK3CA_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANTGFR2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANLTOR3_HUMANBioGRID, HPRD11266467 9733512 details
MP2K1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANBMI1_HUMANBioGRID27878292 details
MP2K1_HUMANSRC_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPPARG_HUMANBioGRID17101779 21690289 details
MP2K1_HUMANHNRPD_HUMANBioGRID15231747 details
MP2K1_HUMANUBC9_HUMANBioGRID21336309 details
MP2K1_HUMANITCH_HUMANBioGRID31015455 details
MP2K1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPEBP4_HUMANBioGRID, HPRD, MINT15302887 19197339 details
MP2K1_HUMANM3K8_HUMANBioGRID, IntAct12832462 16291755 8631303 details
MP2K1_HUMANTCP11_HUMANBioGRID, IntAct32296183 details
MP2K1_HUMANMK08_HUMANBioGRID16533805 details
MP2K1_HUMANMBP_HUMANBioGRID8617731 details
MP2K1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
MP2K1_HUMANM3K4_HUMANBioGRID, HPRD9841871 details
MP2K1_HUMANWNK1_HUMANBioGRID, IntAct20936779 details
MP2K1_HUMANBAX_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANARF_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANMSH6_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANSMAD2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANKAT7_HUMANBioGRID23319590 details
MP2K1_HUMANCADH1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANAPC_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANCDN2A_HUMANBioGRID24412244 details
MP2K1_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
MP2K1_HUMANPIN1_HUMANUniProt20179161 details
MP2K1_HUMANPEBP1_HUMANBioGRID, HPRD10757792 details
MP2K1_HUMANTRIB1_HUMANHPRD, IntAct15299019 details
MP2K1_HUMANKSR1_HUMANBioGRID, HPRD, IntAct11741534 11940661 15090600 15520859 17979178 18332145 26496610 27086506 31980649 details
MP2K1_HUMANYAP1_HUMANBioGRID, MINT24211253 27684187 details
MP2K1_HUMANMP2K2_HUMANBioGRID, IntAct10409742 28514442 details
MP2K1_HUMANNF2L2_HUMANBioGRID24704364 details
MP2K1_HUMANCASP9_HUMANHPRD12792650 details
MP2K1_HUMANCPNE4_HUMANHPRD12522145 details
MP2K1_HUMANFBW1A_HUMANBioGRID, MINT24211253 details
MP2K1_HUMANWDR83_HUMANBioGRID15118098 details
MP2K1_HUMAN1433B_HUMANBioGRID, IntAct10409742 17979178 24255178 31980649 details
MP2K1_HUMANBRAP_HUMANBioGRID18332145 details
MP2K1_HUMANMYC_HUMANBioGRID, HPRD, IntAct26496610 7957875 details
MP2K1_HUMANRASH_HUMANBioGRID, HPRD7969158 details
MP2K1_HUMANKS6A4_HUMANHPRD10806207 details
MP2K1_HUMANKPCZ_HUMANHPRD11535599 details
MP2K1_HUMANM3K1_HUMANBioGRID, MINT10969079 14500727 17110930 details
MP2K1_HUMANPARVA_HUMANHPRD15353548 details
MP2K1_HUMANELK1_HUMANHPRD10716983 10997882 details
MP2K1_HUMANHLAB_HUMANIntAct17353931 details
MP2K1_HUMANCPNE1_HUMANHPRD12522145 details
MP2K1_HUMANEP300_HUMANHPRD11278389 details
MP2K1_HUMANARRB2_HUMANBioGRID11226259 details
MP2K1_HUMANZ3H7A_HUMANBioGRID29395067 details
MP2K1_HUMANKS6A2_HUMANHPRD8939914 details
MP2K1_HUMANMK14_HUMANHPRD12697810 details
MP2K1_HUMANBIRC6_HUMANHPRD, IntAct18329369 details
MP2K1_HUMANPAK1_HUMANHPRD9351825 details
MP2K1_HUMANKPCI_HUMANHPRD10848576 details
MP2K1_HUMANCDK5_HUMANHPRD11684694 details
MP2K1_HUMANTRAF6_HUMANHPRD16313339 details
MP2K1_HUMANVRK2_HUMANIntAct20679487 22752157 details
MP2K1_HUMANIQGA1_HUMANBioGRID24639526 27684187 details
MP2K1_HUMANCALR_HUMANIntAct22752157 details
MP2K1_HUMANLSP1_HUMANBioGRID15090600 details
MP2K1_HUMANKSR2_HUMANBioGRID, HPRD, IntAct12975377 27086506 details
MP2K1_HUMANCFLAR_HUMANMINT17110930 details
MP2K1_HUMANTRIB3_HUMANIntAct15299019 details
MP2K1_HUMANVAV_HUMANBioGRID8900182 details
MP2K1_HUMANLTOR2_HUMANBioGRID11266467 details
MP2K1_HUMANTRAF3_HUMANHPRD8626767 details
MP2K1_HUMANPLK3_HUMANHPRD15021912 details
MP2K1_HUMANEGFR_HUMANHPRD12556561 details