Entity Details

Primary name KMT2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03164
EntryNameKMT2A_HUMAN
FullNameHistone-lysine N-methyltransferase 2A
TaxID9606
Evidenceevidence at protein level
Length3969
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesKMT2A

GO terms

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GOName
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008270 zinc ion binding
GO:0032411 positive regulation of transporter activity
GO:0032922 circadian regulation of gene expression
GO:0035097 histone methyltransferase complex
GO:0035162 embryonic hemopoiesis
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043984 histone H4-K16 acetylation
GO:0044648 histone H3-K4 dimethylation
GO:0045322 unmethylated CpG binding
GO:0045652 regulation of megakaryocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051568 histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0065003 protein-containing complex assembly
GO:0070577 lysine-acetylated histone binding
GO:0071339 MLL1 complex
GO:0071440 regulation of histone H3-K14 acetylation
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation
GO:0106363 protein-cysteine methyltransferase activity
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1905642 negative regulation of DNA methylation
GO:2000615 regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001487 BromodomainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR003888 FY-rich, N-terminalDomainDomain
IPR003889 FY-rich, C-terminalDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR016569 Methyltransferase, trithoraxFamilyFamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR034732 Extended PHD (ePHD) domainDomainDomain
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037927 Histone-lysine N-methyltransferase 2AFamilyFamily
IPR041958 KMT2A, ePHD domainDomainDomain
IPR042023 KMT2A, PHD domain 1DomainDomain
IPR042025 KMT2A, PHD domain 2DomainDomain
IPR044133 KMT2A, PHD domain 3DomainDomain

Diseases

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Interactions

94 interactions

InteractorPartnerSourcesPublicationsLink
KMT2A_HUMANKMT2A_HUMANBioGRID, HPRD, IntAct10656681 11313484 12393701 12482972 24235145 details
KMT2A_HUMANPPIE_HUMANBioGRID, HPRD, IntAct11313484 18676843 20541251 details
KMT2A_HUMANASH2L_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt15199122 15960975 16892064 19556245 20064463 20305087 21285357 22665483 23870121 24235145 24981860 26886794 27563068 28182322 31076518 31544921 31685992 34079125 details
KMT2A_HUMANMEN1_HUMANBioGRID, DIP, HPRD, IntAct15199122 16199523 16239140 16618927 17671196 18598942 19818711 20064463 20818375 22327296 24981860 details
KMT2A_HUMANRBBP5_HUMANBioGRID, DIP, HPRD, IntAct, UniProt15199122 15960975 19556245 20064463 21220120 22665483 23870121 24081332 24981860 26886794 27563068 28182322 31076518 31400120 31544921 31685992 details
KMT2A_HUMANPAF1_HUMANBioGRID, IntAct20541477 details
KMT2A_HUMANCTR9_HUMANBioGRID, IntAct20541477 details
KMT2A_HUMANH31_HUMANBioGRID, IntAct12453419 20452361 20541251 24235145 24680668 29897600 31485071 31544921 34079125 details
KMT2A_HUMANWDR5_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt15199122 15960975 18840606 19556245 20305087 20581860 20818375 21220120 22266653 22665483 22989411 23870121 24680668 24981860 26186194 27192115 27563068 27705803 28182322 28514442 31400120 31544921 31685992 32076268 details
KMT2A_HUMANKAT8_HUMANBioGRID, HPRD, UniProt15960975 24981860 details
KMT2A_HUMANP53_HUMANBioGRID, UniProt15960975 23443559 details
KMT2A_HUMANCLOCK_HUMANDIP25751424 details
KMT2A_HUMANSIR1_HUMANDIP25751424 details
KMT2A_HUMANTOPB1_HUMANUniProt17913746 details
KMT2A_HUMANPR15A_HUMANBioGRID, HPRD10490642 details
KMT2A_HUMANNEU2_HUMANBioGRID14607844 details
KMT2A_HUMANINS_HUMANBioGRID14607844 details
KMT2A_HUMANNEU1_HUMANBioGRID14607844 details
KMT2A_HUMANHDAC1_HUMANBioGRID12453419 12829790 details
KMT2A_HUMANCTBP1_HUMANBioGRID12829790 details
KMT2A_HUMANCBX4_HUMANBioGRID12829790 details
KMT2A_HUMANBMI1_HUMANBioGRID, HPRD12829790 details
KMT2A_HUMANCBP_HUMANBioGRID, HPRD11259575 12205094 16799563 17707401 details
KMT2A_HUMANCTNB1_HUMANBioGRID16510874 16510875 details
KMT2A_HUMANRPB1_HUMANBioGRID16199523 details
KMT2A_HUMANMTMR5_HUMANBioGRID9537414 details
KMT2A_HUMANMTM1_HUMANBioGRID9537414 details
KMT2A_HUMANSET_HUMANBioGRID, HPRD9353299 details
KMT2A_HUMANH4_HUMANBioGRID20452361 27248496 30804502 details
KMT2A_HUMANH31T_HUMANBioGRID21030982 21124902 21135039 26324722 28182322 details
KMT2A_HUMANSVIL_HUMANBioGRID, HPRD20309963 details
KMT2A_HUMANH32_HUMANBioGRID21726816 details
KMT2A_HUMANH33_HUMANBioGRID17166833 details
KMT2A_HUMANTOP1_HUMANBioGRID12549820 details
KMT2A_HUMANTAF9_HUMANBioGRID, HPRD10821850 12453419 details
KMT2A_HUMANTASP1_HUMANBioGRID, HPRD12393701 12482972 14636557 details
KMT2A_HUMANGCR_HUMANIntAct20195357 details
KMT2A_HUMANCDC73_HUMANBioGRID, IntAct20541477 details
KMT2A_HUMANRING2_HUMANBioGRID, HPRD, UniProt15960975 details
KMT2A_HUMANPAX5_HUMANIntAct24735925 details
KMT2A_HUMANDPY30_HUMANBioGRID, DIP, UniProt17500065 24981860 31485071 31685992 details
KMT2A_HUMANSKP2_HUMANBioGRID, DIP20818375 23868976 details
KMT2A_HUMANPSIP1_HUMANBioGRID, DIP18598942 22327296 details
KMT2A_HUMANANDR_HUMANBioGRID, DIP22722839 details
KMT2A_HUMANM3K5_HUMANBioGRID14607843 details
KMT2A_HUMANSNF5_HUMANBioGRID10490642 12453419 details
KMT2A_HUMANCXXC1_HUMANBioGRID18082152 24981860 details
KMT2A_HUMANMYB_HUMANBioGRID20093773 details
KMT2A_HUMANSNW1_HUMANBioGRID19818711 details
KMT2A_HUMANE2F2_HUMANBioGRID16951254 details
KMT2A_HUMANE2F4_HUMANBioGRID16951254 details
KMT2A_HUMANE2F6_HUMANBioGRID16951254 details
KMT2A_HUMANAFAD_HUMANBioGRID16239140 details
KMT2A_HUMANKAT6A_HUMANBioGRID20581860 23994619 details
KMT2A_HUMANELL_HUMANBioGRID20153263 details
KMT2A_HUMANAFF1_HUMANBioGRID20153263 21030982 details
KMT2A_HUMANAFF4_HUMANBioGRID20153263 22094252 details
KMT2A_HUMANCDK9_HUMANBioGRID20153263 20854876 22094252 details
KMT2A_HUMANCCNT1_HUMANBioGRID20153263 22094252 details
KMT2A_HUMANAF9_HUMANBioGRID20854876 21896721 details
KMT2A_HUMANDOT1L_HUMANBioGRID20854876 22094252 details
KMT2A_HUMANSIN3A_HUMANBioGRID12453419 20153263 details
KMT2A_HUMANENL_HUMANBioGRID20153263 details
KMT2A_HUMANRUNX1_HUMANBioGRID22012064 details
KMT2A_HUMANPEBB_HUMANBioGRID22012064 details
KMT2A_HUMANASB2_HUMANBioGRID22174154 details
KMT2A_HUMANELOC_HUMANBioGRID22174154 details
KMT2A_HUMANELOB_HUMANBioGRID22174154 details
KMT2A_HUMANCBX8_HUMANBioGRID22094252 details
KMT2A_HUMANTAF6_HUMANBioGRID12453419 22939629 details
KMT2A_HUMANSENP3_HUMANBioGRID24930734 details
KMT2A_HUMANSYMPK_HUMANBioGRID23994619 details
KMT2A_HUMANPKN1_HUMANBioGRID24793694 details
KMT2A_HUMANTAF1_HUMANBioGRID12453419 details
KMT2A_HUMANCHD3_HUMANBioGRID12453419 details
KMT2A_HUMANSMCA2_HUMANBioGRID12453419 details
KMT2A_HUMANSMRC2_HUMANBioGRID12453419 details
KMT2A_HUMANSMRC1_HUMANBioGRID12453419 details
KMT2A_HUMANHDAC2_HUMANBioGRID12453419 details
KMT2A_HUMANRBBP4_HUMANBioGRID12453419 details
KMT2A_HUMANRBBP7_HUMANBioGRID12453419 details
KMT2A_HUMANTBP_HUMANBioGRID12453419 details
KMT2A_HUMANMBD3_HUMANBioGRID12453419 details
KMT2A_HUMANSAP30_HUMANBioGRID12453419 details
KMT2A_HUMANRAN_HUMANBioGRID12453419 details
KMT2A_HUMANCKS1_HUMANBioGRID28939057 details
KMT2A_HUMANCKS2_HUMANBioGRID28939057 details
KMT2A_HUMANSOX2_HUMANBioGRID30089852 details
KMT2A_HUMANSP1_HUMANBioGRID28094252 details
KMT2A_HUMANPTEN_HUMANBioGRID31685992 details
KMT2A_HUMANSPT5H_HUMANBioGRID29395067 details
KMT2A_HUMANCDC27_HUMANBioGRID32076268 details
KMT2A_HUMANTNFL6_HUMANHPRD12023017 details
KMT2A_HUMANPLXB1_HUMANHPRD12123608 details