Entity Details

Primary name IF4G1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04637
EntryNameIF4G1_HUMAN
FullNameEukaryotic translation initiation factor 4 gamma 1
TaxID9606
Evidenceevidence at protein level
Length1599
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesEIF4G1

GO terms

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GOName
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001662 behavioral fear response
GO:0002191 cap-dependent translational initiation
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008135 translation factor activity, RNA binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0010494 cytoplasmic stress granule
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010942 positive regulation of cell death
GO:0016020 membrane
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0030307 positive regulation of cell growth
GO:0031369 translation initiation factor binding
GO:0031669 cellular response to nutrient levels
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032502 developmental process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034645 cellular macromolecule biosynthetic process
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042802 identical protein binding
GO:0043488 regulation of mRNA stability
GO:0045666 positive regulation of neuron differentiation
GO:0060090 molecular adaptor activity
GO:0060964 regulation of gene silencing by miRNA
GO:0080135 regulation of cellular response to stress
GO:0097009 energy homeostasis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901215 negative regulation of neuron death
GO:1905537 positive regulation of eukaryotic translation initiation factor 4F complex assembly
GO:1905606 regulation of presynapse assembly
GO:1905612 positive regulation of mRNA cap binding
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1905696 regulation of polysome binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003307 W2 domainDomainDomain
IPR003890 MIF4G-like, type 3DomainDomain
IPR003891 Initiation factor eIF-4 gamma, MA3DomainDomain
IPR016021 MIF4G-like domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR037584 Eukaryotic translation initiation factor 4 gamma 1FamilyFamily

Diseases

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Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
IF4G1_HUMANPABP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12086624 16772376 19716330 26344197 9857202 details
IF4G1_HUMANHSPB1_HUMANHPRD, MINT10859165 details
IF4G1_HUMANMKNK1_HUMANBioGRID, HPRD, MINT15234964 9878069 details
IF4G1_HUMANIF4A1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11408474 16541103 16648488 16932749 17053147 17353931 18606994 19203580 22586265 22939629 23023399 23478064 24768540 26344197 27864334 28514442 29395067 9372926 9418880 details
IF4G1_HUMANIF4E_HUMANBioGRID, DIP, HPRD, IntAct, MINT10600798 10753870 12071973 15153109 15361857 16281055 16541103 16648488 16720573 18955708 20212144 21191102 22509910 22586265 23665581 24981860 25923732 25940091 26186194 26344197 27864334 28514442 29987188 30573685 7651417 9372926 9418880 details
IF4G1_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15231748 details
IF4G1_HUMANANXA5_HUMANHPRD, IntAct16169070 details
IF4G1_HUMANHNRPD_HUMANBioGRID, IntAct10205060 16556936 18573886 26496610 details
IF4G1_HUMANGLPK_HUMANBioGRID, IntAct21988832 details
IF4G1_HUMANCENPU_HUMANBioGRID, MINT21900206 details
IF4G1_HUMANUBE3A_HUMANBioGRID, MINT21900206 details
IF4G1_HUMANDDX3X_HUMANMINT22872150 details
IF4G1_HUMANFXR2_HUMANBioGRID, IntAct, MINT23974796 32296183 details
IF4G1_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCIB1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANSMRD1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCDN2D_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANCTBP2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANATPF2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANPEF1_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANDTX2_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANA1CF_HUMANBioGRID, IntAct32296183 details
IF4G1_HUMANIF4G1_HUMANDIP16698552 details
IF4G1_HUMANRBM4_HUMANDIP17284590 details
IF4G1_HUMANMKNK2_HUMANBioGRID12897141 details
IF4G1_HUMANTRAF2_HUMANBioGRID15743837 details
IF4G1_HUMANHTRA2_HUMANBioGRID17266347 details
IF4G1_HUMANSRPK2_HUMANBioGRID26167880 details
IF4G1_HUMANEIF1_HUMANBioGRID29987188 details
IF4G1_HUMANSUMO2_HUMANBioGRID32786267 details
IF4G1_HUMANIF4A2_HUMANBioGRID, HPRD, IntAct, MINT11408474 17353931 24768540 24981860 26344197 29395067 details
IF4G1_HUMANNCBP1_HUMANBioGRID, HPRD, IntAct11340157 15361857 25049393 details
IF4G1_HUMANPDCD4_HUMANBioGRID, HPRD, IntAct12054647 details
IF4G1_HUMANEIF3J_HUMANMINT16932749 details
IF4G1_HUMANCRCM_HUMANIntAct17353931 details
IF4G1_HUMANARF6_HUMANIntAct17353931 details
IF4G1_HUMANPAK2_HUMANHPRD, IntAct16281055 17353931 details
IF4G1_HUMANEPB41_HUMANIntAct17353931 details
IF4G1_HUMANAAKB1_HUMANIntAct17353931 details
IF4G1_HUMANIKKE_HUMANIntAct17353931 details
IF4G1_HUMANTRAF6_HUMANIntAct17353931 details
IF4G1_HUMAN1433Z_HUMANMINT15161933 details
IF4G1_HUMANZ3H7B_HUMANIntAct15047801 details
IF4G1_HUMANG3BP1_HUMANBioGRID, MINT, UniProt18005740 19615732 23209657 26777405 details
IF4G1_HUMANEIF3B_HUMANBioGRID, HPRD, MINT16541103 23023399 24981860 27381497 9418880 details
IF4G1_HUMANEIF3I_HUMANBioGRID, HPRD, IntAct16541103 24981860 26186194 28514442 details
IF4G1_HUMANDISC1_HUMANIntAct31413325 details
IF4G1_HUMANEIF3A_HUMANBioGRID, HPRD16541103 24981860 details
IF4G1_HUMANUBP10_HUMANBioGRID19615732 27003362 27022092 32382008 details
IF4G1_HUMANEIF3H_HUMANBioGRID19615732 24981860 32269044 details
IF4G1_HUMANISG15_HUMANBioGRID16009940 33024031 details
IF4G1_HUMANIF4B_HUMANBioGRID22939629 26344197 27864334 details
IF4G1_HUMANITA4_HUMANBioGRID22623428 details
IF4G1_HUMANBRCA1_HUMANBioGRID23805307 26831064 details
IF4G1_HUMANPDIP3_HUMANBioGRID25049393 details
IF4G1_HUMANSLBP_HUMANBioGRID27773672 details
IF4G1_HUMANOTU6B_HUMANBioGRID27864334 details
IF4G1_HUMANCDC37_HUMANBioGRID16611982 details
IF4G1_HUMANSRSF3_HUMANBioGRID27381497 details
IF4G1_HUMANG3BP2_HUMANBioGRID31114027 details
IF4G1_HUMANIF5_HUMANHPRD11331597 details