Entity Details

Primary name ACVR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04771
EntryNameACVR1_HUMAN
FullNameActivin receptor type-1
TaxID9606
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesACVR1

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001707 mesoderm formation
GO:0001755 neural crest cell migration
GO:0002526 acute inflammatory response
GO:0003143 embryonic heart tube morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003289 atrial septum primum morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0009953 dorsal/ventral pattern formation
GO:0009968 negative regulation of signal transduction
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 activin receptor activity, type I
GO:0017046 peptide hormone binding
GO:0018107 peptidyl-threonine phosphorylation
GO:0030278 regulation of ossification
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051145 smooth muscle cell differentiation
GO:0060037 pharyngeal system development
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060923 cardiac muscle cell fate commitment
GO:0061312 BMP signaling pathway involved in heart development
GO:0061445 endocardial cushion cell fate commitment
GO:0070724 BMP receptor complex
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1990782 protein tyrosine kinase binding
GO:2000017 positive regulation of determination of dorsal identity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB08597 DorsomorphinDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
ACVR1_HUMANTGFR1_HUMANHPRD, IntAct15761153 24658140 details
ACVR1_HUMANBMPR2_HUMANBioGRID, IntAct28514442 7791754 7890683 details
ACVR1_HUMANBMR1A_HUMANBioGRID, IntAct18436533 26186194 28514442 details
ACVR1_HUMANFNTA_HUMANBioGRID, HPRD8599089 details
ACVR1_HUMANBMP7_HUMANBioGRID, HPRD18070108 8006002 details
ACVR1_HUMANSMAD1_HUMANBioGRID, HPRD10085121 10583507 10652350 28847510 9136927 9748228 details
ACVR1_HUMANTGFR2_HUMANBioGRID7890683 details
ACVR1_HUMANBAMBI_HUMANBioGRID19758997 details
ACVR1_HUMANACVR1_HUMANBioGRID18436533 details
ACVR1_HUMANOTUB1_HUMANBioGRID25872870 details
ACVR1_HUMANFBX7_HUMANBioGRID27503909 details
ACVR1_HUMANTDGF1_HUMANBioGRID28126904 details
ACVR1_HUMANBMP6_HUMANBioGRID18070108 details
ACVR1_HUMANGDF2_HUMANBioGRID17311849 details
ACVR1_HUMANSTIP1_HUMANBioGRID22884369 details
ACVR1_HUMANRXRA_HUMANHPRD9267036 details
ACVR1_HUMANTHB_HUMANHPRD9267036 details
ACVR1_HUMANVDR_HUMANHPRD9267036 details
ACVR1_HUMANGDF5_HUMANBioGRID, HPRD8702914 details
ACVR1_HUMANEGLN_HUMANBioGRID, HPRD9872992 details
ACVR1_HUMANSMAD5_HUMANBioGRID, HPRD10583507 10652350 9748228 details
ACVR1_HUMANACV1B_HUMANBioGRID26186194 8612709 details
ACVR1_HUMANT22D1_HUMANBioGRID21791611 details
ACVR1_HUMANIGSF1_HUMANBioGRID, HPRD11266516 details
ACVR1_HUMANSMUF1_HUMANBioGRID12857866 31685442 details
ACVR1_HUMANSMAD6_HUMANBioGRID20663871 23455153 details
ACVR1_HUMANSMAD7_HUMANBioGRID20663871 details
ACVR1_HUMANPEG10_HUMANBioGRID15611116 details
ACVR1_HUMANINHBA_HUMANBioGRID, HPRD11266516 8242742 details
ACVR1_HUMANAVR2A_HUMANBioGRID8242742 details
ACVR1_HUMANUBP15_HUMANBioGRID24850914 details
ACVR1_HUMANRGMB_HUMANBioGRID15671031 details
ACVR1_HUMANFKB1A_HUMANBioGRID22977237 details
ACVR1_HUMANPSDE_HUMANBioGRID31685442 details
ACVR1_HUMANCHIP_HUMANBioGRID31685442 details
ACVR1_HUMANBMP2_HUMANHPRD8006002 details
ACVR1_HUMANINHBB_HUMANHPRD11266516 details
ACVR1_HUMANINHBC_HUMANHPRD12651901 details
ACVR1_HUMANSMAD9_HUMANHPRD10583507 details
ACVR1_HUMANCBP_HUMANHPRD9267036 details
ACVR1_HUMANAP2B1_HUMANHPRD15761153 details
ACVR1_HUMANCHIN_HUMANHPRD15761153 details
ACVR1_HUMANDS13A_HUMANHPRD15761153 details
ACVR1_HUMANFANCL_HUMANHPRD15761153 details
ACVR1_HUMANFBX30_HUMANHPRD15761153 details
ACVR1_HUMANFCHO1_HUMANHPRD15761153 details
ACVR1_HUMANFGD6_HUMANHPRD15761153 details
ACVR1_HUMANFKBP4_HUMANHPRD15761153 details
ACVR1_HUMANIKKB_HUMANHPRD15761153 details
ACVR1_HUMANDCAF6_HUMANHPRD15761153 details
ACVR1_HUMANNEK8_HUMANHPRD15761153 details
ACVR1_HUMANKBRS1_HUMANHPRD15761153 details
ACVR1_HUMANRASN_HUMANHPRD15761153 details
ACVR1_HUMANNUAK2_HUMANHPRD15761153 details
ACVR1_HUMANPAK1_HUMANHPRD15761153 details
ACVR1_HUMANCDK14_HUMANHPRD15761153 details
ACVR1_HUMANPLEK_HUMANHPRD15761153 details
ACVR1_HUMANPKHB1_HUMANHPRD15761153 details
ACVR1_HUMANPKHJ1_HUMANHPRD15761153 details
ACVR1_HUMANRAB17_HUMANHPRD15761153 details
ACVR1_HUMANRAB25_HUMANHPRD15761153 details
ACVR1_HUMANRB33B_HUMANHPRD15761153 details
ACVR1_HUMANRAB3B_HUMANHPRD15761153 details
ACVR1_HUMANRAB6B_HUMANHPRD15761153 details
ACVR1_HUMANRAP2A_HUMANHPRD15761153 details
ACVR1_HUMANRHES_HUMANHPRD15761153 details
ACVR1_HUMANRASLC_HUMANHPRD15761153 details
ACVR1_HUMANREBL1_HUMANHPRD15761153 details
ACVR1_HUMANRHOD_HUMANHPRD15761153 details
ACVR1_HUMANRHOJ_HUMANHPRD15761153 details
ACVR1_HUMANRS27A_HUMANHPRD15761153 details
ACVR1_HUMANRRAS2_HUMANHPRD15761153 details
ACVR1_HUMANSOCS6_HUMANHPRD15761153 details
ACVR1_HUMANSTX8_HUMANHPRD15761153 details
ACVR1_HUMANTTC17_HUMANHPRD15761153 details
ACVR1_HUMANRL40_HUMANHPRD15761153 details
ACVR1_HUMANUB2E3_HUMANHPRD15761153 details
ACVR1_HUMANSNUT2_HUMANHPRD15761153 details
ACVR1_HUMANMELT_HUMANHPRD15761153 details
ACVR1_HUMANWDR61_HUMANHPRD15761153 details
ACVR1_HUMANKLH35_HUMANHPRD15761153 details
ACVR1_HUMANUBXN1_HUMANHPRD15761153 details
ACVR1_HUMANTTC27_HUMANHPRD15761153 details