Entity Details

Primary name FAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05397
EntryNameFAK1_HUMAN
FullNameFocal adhesion kinase 1
TaxID9606
Evidenceevidence at protein level
Length1052
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPTK2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001725 stress fiber
GO:0001890 placenta development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003779 actin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008432 JUN kinase binding
GO:0010594 regulation of endothelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030010 establishment of cell polarity
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035995 detection of muscle stretch
GO:0036064 ciliary basal body
GO:0038007 netrin-activated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0043066 negative regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048870 cell motility
GO:0051493 regulation of cytoskeleton organization
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060396 growth hormone receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:0120041 positive regulation of macrophage proliferation
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR005189 Focal adhesion kinase, targeting (FAT) domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamilyFamilyHomologous superfamily
IPR041390 Focal adhesion kinase, N-terminalDomainDomain
IPR041784 FAK1/PYK2, FERM domain C-lobeDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06423 EndostatinDrugbankbiotech
DB07248 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINEDrugbanksmall molecule
DB07460 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

133 interactions

InteractorPartnerSourcesPublicationsLink
FAK1_HUMANLYN_HUMANBioGRID, IntAct, MINT11389892 25814554 9169439 details
FAK1_HUMANEGFR_HUMANBioGRID, IntAct10806474 15657067 20473329 24658140 25402006 31980649 details
FAK1_HUMANBCAR1_HUMANBioGRID, MINT, Molecular Connections10753828 11577104 11839772 12135674 12615911 15673687 21034468 21855630 8649427 8810278 9285683 details
FAK1_HUMANSRC_HUMANBioGRID, IntAct, MINT, Molecular Connections10085298 11104793 11119718 11980671 12387730 12558988 12615911 15987550 16291744 16966330 17525734 21034468 21855630 22402981 23065768 23242524 25241761 25814554 26264872 32814053 8816475 9822703 details
FAK1_HUMANP53_HUMANBioGRID, IntAct, MINT15855171 18206965 19857493 25241761 27736841 details
FAK1_HUMANPAXI_HUMANBioGRID, IntAct, mbinfo, Molecular Connections, UniProt10330411 10455189 10753828 10980697 11514617 11919182 15987550 21034468 21741599 22270917 22761432 25391654 28415719 30120307 31980649 34079125 7561682 8922390 9054445 9422762 9442086 9756887 details
FAK1_HUMANTGFI1_HUMANBioGRID, MINT, UniProt11463817 21900206 9422762 9756887 9858471 details
FAK1_HUMANTENS3_HUMANBioGRID, IntAct15140944 19732724 details
FAK1_HUMANDCC_HUMANBioGRID, IntAct15494733 20434207 28701345 details
FAK1_HUMANGRB2_HUMANBioGRID, IntAct, MINT10085298 10806474 12005431 12558988 20473329 21900206 7597091 8649427 8816475 details
FAK1_HUMANRAC1_HUMANBioGRID, IntAct20936779 details
FAK1_HUMANSAE1_HUMANBioGRID, IntAct21988832 details
FAK1_HUMANBBS10_HUMANBioGRID, MINT21900206 details
FAK1_HUMANDX39A_HUMANBioGRID, MINT21900206 details
FAK1_HUMANEF1G_HUMANBioGRID, MINT21900206 details
FAK1_HUMANES8L2_HUMANBioGRID, MINT21900206 details
FAK1_HUMANF13A_HUMANBioGRID, MINT21900206 details
FAK1_HUMANF16P1_HUMANBioGRID, MINT21900206 details
FAK1_HUMANHES1_HUMANBioGRID, MINT21900206 details
FAK1_HUMANLPXN_HUMANBioGRID, IntAct, MINT21900206 28514442 details
FAK1_HUMANNACAD_HUMANBioGRID, MINT21900206 details
FAK1_HUMANNASP_HUMANBioGRID, MINT21900206 details
FAK1_HUMANZN331_HUMANBioGRID, MINT21900206 details
FAK1_HUMANPTN23_HUMANMINT18835089 details
FAK1_HUMANCRK_HUMANBioGRID, IntAct, mbinfo10085298 12615911 25814554 7561682 details
FAK1_HUMANP55G_HUMANBioGRID, IntAct22402981 25814554 32296183 details
FAK1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
FAK1_HUMANSTAT1_HUMANBioGRID, IntAct11278462 20576130 25241761 details
FAK1_HUMANYES_HUMANBioGRID, IntAct12558988 23397142 25416956 32296183 details
FAK1_HUMANPTEN_HUMANBioGRID, IntAct10400703 11857088 15717329 23397142 9927060 details
FAK1_HUMANFAK1_HUMANBioGRID, MINT12005431 16141199 24480479 25391654 8816475 details
FAK1_HUMANPTN6_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANSH21A_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANDOK4_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANSH22A_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANGRB7_HUMANBioGRID, IntAct10446223 11119718 25814554 details
FAK1_HUMANSH21B_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANHCK_HUMANBioGRID, IntAct25814554 details
FAK1_HUMANIRS1_HUMANBioGRID9822703 details
FAK1_HUMANSOCS2_HUMANBioGRID16189514 details
FAK1_HUMANATG12_HUMANBioGRID16189514 details
FAK1_HUMANGIT1_HUMANBioGRID10938112 12473661 12629171 details
FAK1_HUMANITB5_HUMANBioGRID11927607 15673687 details
FAK1_HUMANITB3_HUMANBioGRID11927607 19889638 9169439 details
FAK1_HUMANJIP3_HUMANBioGRID12226752 16141199 details
FAK1_HUMANEZRI_HUMANBioGRID11468295 details
FAK1_HUMANBMX_HUMANBioGRID11331870 details
FAK1_HUMANTSC2_HUMANBioGRID17043358 details
FAK1_HUMANRHG26_HUMANBioGRID8649427 details
FAK1_HUMANNCK1_HUMANBioGRID11950595 8879209 details
FAK1_HUMANTLN1_HUMANBioGRID25391654 7622520 9442086 details
FAK1_HUMANCASL_HUMANBioGRID8668148 details
FAK1_HUMANP85A_HUMANBioGRID10973983 11104793 11119718 19889638 7537275 details
FAK1_HUMANRBCC1_HUMANBioGRID10769033 details
FAK1_HUMANNCK2_HUMANBioGRID11950595 details
FAK1_HUMANNEO1_HUMANBioGRID15494733 details
FAK1_HUMANMDM2_HUMANBioGRID18206965 details
FAK1_HUMANSOCS3_HUMANBioGRID14517242 16007195 18031698 25416956 details
FAK1_HUMANA4_HUMANBioGRID21832049 details
FAK1_HUMANDEFI6_HUMANBioGRID25416956 32296183 details
FAK1_HUMANLYAM2_HUMANBioGRID8609175 details
FAK1_HUMANTRI15_HUMANBioGRID25450970 details
FAK1_HUMANSOCS1_HUMANBioGRID14517242 details
FAK1_HUMANLCK_HUMANBioGRID26871637 details
FAK1_HUMANZFY21_HUMANBioGRID20890123 details
FAK1_HUMANKCNB1_HUMANBioGRID18615577 details
FAK1_HUMANCCNA1_HUMANBioGRID, IntAct17353931 25241761 details
FAK1_HUMANRHOU_HUMANIntAct18086875 details
FAK1_HUMANDVLP1_HUMANMINT20224554 details
FAK1_HUMANERBB2_HUMANBioGRID, IntAct, Molecular Connections12600989 21034468 25241761 details
FAK1_HUMANEPHA2_HUMANBioGRID, UniProt10655584 details
FAK1_HUMANPTH2_HUMANBioGRID, IntAct21383007 details
FAK1_HUMANHS90B_HUMANIntAct22939624 details
FAK1_HUMANSTAT3_HUMANBioGRID, IntAct10925297 25241761 details
FAK1_HUMANCRKL_HUMANIntAct23397142 details
FAK1_HUMANVGFR1_HUMANIntAct23397142 details
FAK1_HUMANITAV_HUMANBioGRID, IntAct12844492 19889638 23397142 details
FAK1_HUMANPLCG1_HUMANBioGRID, IntAct10430888 23397142 details
FAK1_HUMANITB4_HUMANMINT27178753 details
FAK1_HUMANCASS4_HUMANIntAct31413325 details
FAK1_HUMANDISC1_HUMANIntAct31413325 details
FAK1_HUMANFYN_HUMANBioGRID, IntAct11278857 12558988 31413325 details
FAK1_HUMANPTN11_HUMANBioGRID, IntAct10082579 20473329 21726809 details
FAK1_HUMANTRIP6_HUMANBioGRID14688263 details
FAK1_HUMANCIB1_HUMANBioGRID12881299 details
FAK1_HUMANDOCK1_HUMANBioGRID12615911 details
FAK1_HUMANJAK2_HUMANBioGRID10925297 9553131 details
FAK1_HUMANSHC1_HUMANBioGRID11980671 details
FAK1_HUMANCCR5_HUMANBioGRID10384144 details
FAK1_HUMANGSK3B_HUMANBioGRID11809746 details
FAK1_HUMANCXCR4_HUMANBioGRID11668182 details
FAK1_HUMANTSC1_HUMANBioGRID17043358 details
FAK1_HUMANIGF1R_HUMANBioGRID10082579 details
FAK1_HUMANITA4_HUMANBioGRID11919182 details
FAK1_HUMANFGR_HUMANBioGRID12387730 details
FAK1_HUMANGELS_HUMANBioGRID11577104 details
FAK1_HUMANAMPH_HUMANBioGRID12558988 details
FAK1_HUMANBIN1_HUMANBioGRID12558988 details
FAK1_HUMANPP1B_HUMANBioGRID11513739 17274640 details
FAK1_HUMANKSYK_HUMANBioGRID9169439 9342235 details
FAK1_HUMANCSK_HUMANBioGRID7529872 details
FAK1_HUMANG3P_HUMANBioGRID18206965 details
FAK1_HUMANPARP1_HUMANBioGRID18206965 details
FAK1_HUMANCBL_HUMANBioGRID12771190 17675501 22203672 details
FAK1_HUMANDAG1_HUMANBioGRID18341635 details
FAK1_HUMANSH3K1_HUMANBioGRID12771190 details
FAK1_HUMANPDC6I_HUMANBioGRID12771190 details
FAK1_HUMANSRC8_HUMANBioGRID17893324 details
FAK1_HUMANASAP1_HUMANBioGRID15632162 17893324 18786926 34079125 details
FAK1_HUMANSTAP2_HUMANBioGRID17675501 details
FAK1_HUMANCHIP_HUMANBioGRID22734001 details
FAK1_HUMANPTAFR_HUMANBioGRID20576130 details
FAK1_HUMANRBNS5_HUMANBioGRID19931244 details
FAK1_HUMANTRI72_HUMANBioGRID24344130 27810898 details
FAK1_HUMANUBE2H_HUMANBioGRID24344130 details
FAK1_HUMANIQGA1_HUMANBioGRID24639526 details
FAK1_HUMANPKD1_HUMANBioGRID11113628 27775029 details
FAK1_HUMANGBB1_HUMANBioGRID19917775 details
FAK1_HUMANGBG2_HUMANBioGRID19917775 details
FAK1_HUMANITB1_HUMANBioGRID19889638 25792870 26992741 details
FAK1_HUMANTIE2_HUMANBioGRID25792870 details
FAK1_HUMANAKT1_HUMANBioGRID25792870 details
FAK1_HUMANCADH5_HUMANBioGRID22720799 details
FAK1_HUMANMERL_HUMANBioGRID27736841 details
FAK1_HUMANCBLB_HUMANBioGRID27446403 32158232 details
FAK1_HUMANDYN1_HUMANBioGRID7597091 details
FAK1_HUMANNEP_HUMANBioGRID11104793 details
FAK1_HUMANXIAP_HUMANBioGRID22366087 details
FAK1_HUMANPBIP1_HUMANBioGRID25486428 details
FAK1_HUMANDYN2_HUMANBioGRID21411625 details
FAK1_HUMANMK08_HUMANBioGRID16141199 details
FAK1_HUMANTRAF2_HUMANBioGRID30373932 details
FAK1_HUMANKPCI_HUMANBioGRID32158232 details