Entity Details

Primary name EXOS9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06265
EntryNameEXOS9_HUMAN
FullNameExosome complex component RRP45
TaxID9606
Evidenceevidence at protein level
Length439
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesEXOSC9

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000228 nuclear chromosome
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0006955 immune response
GO:0016075 rRNA catabolic process
GO:0030307 positive regulation of cell growth
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034473 U1 snRNA 3'-end processing
GO:0034475 U4 snRNA 3'-end processing
GO:0034476 U5 snRNA 3'-end processing
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070062 extracellular exosome
GO:0071028 nuclear mRNA surveillance
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001247 Exoribonuclease, phosphorolytic domain 1DomainDomain
IPR015847 Exoribonuclease, phosphorolytic domain 2DomainDomain
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027408 PNPase/RNase PH domain superfamilyFamilyHomologous superfamily
IPR033100 Exosome complex component RRP45FamilyFamily
IPR036345 Exoribonuclease, PH domain 2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
EXOS9_HUMANDX39B_HUMANHPRD, IntAct14667819 details
EXOS9_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11719186 12788944 15231747 20531386 22939629 24981860 26344197 26496610 27173435 30021884 unassigned1312 details
EXOS9_HUMANUBC9_HUMANBioGRID, IntAct19549727 20936779 details
EXOS9_HUMANEXOS3_HUMANBioGRID, HPRD, IntAct, MINT12788944 20531389 22939629 24981860 26186194 26344197 26496610 28514442 details
EXOS9_HUMANRRP44_HUMANBioGRID, HPRD, MINT11719186 12788944 20531386 26344197 details
EXOS9_HUMANEXOS2_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 17412707 17545563 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS9_HUMANEXOS7_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 24981860 26186194 26344197 26496610 27173435 28514442 unassigned1312 details
EXOS9_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
EXOS9_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
EXOS9_HUMANSETX_HUMANUniProt24244371 details
EXOS9_HUMANEXOS1_HUMANBioGRID, DIP, HPRD, IntAct11719186 12419256 12788944 24981860 25043052 26344197 26496610 28514442 details
EXOS9_HUMANEXOS5_HUMANBioGRID, HPRD, IntAct, MINT11719186 12788944 22939629 24981860 26344197 26496610 details
EXOS9_HUMANEXOS8_HUMANBioGRID, HPRD, IntAct11719186 12788944 24981860 26186194 26496610 28514442 details
EXOS9_HUMANEXOS6_HUMANBioGRID, HPRD, IntAct11719186 12788944 24981860 26344197 26496610 details
EXOS9_HUMANHBS1L_HUMANBioGRID, IntAct24981860 26496610 27345150 details
EXOS9_HUMANCHM4B_HUMANBioGRID, HPRD, IntAct16730941 details
EXOS9_HUMANCHM1A_HUMANIntAct16730941 details
EXOS9_HUMANCHMP5_HUMANIntAct16730941 details
EXOS9_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
EXOS9_HUMANMPH6_HUMANBioGRID24981860 26344197 26496610 28877463 details
EXOS9_HUMANEXOS9_HUMANHPRD14667819 details
EXOS9_HUMANDX39A_HUMANHPRD14667819 details
EXOS9_HUMANLUM_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANLRC47_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANSLIT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANRSRC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANAICDA_HUMANBioGRID21255825 details
EXOS9_HUMAN3MG_HUMANBioGRID23537643 details
EXOS9_HUMANYBOX1_HUMANBioGRID26343856 details
EXOS9_HUMANMTREX_HUMANBioGRID, HPRD11719186 24981860 details
EXOS9_HUMANPALS2_HUMANHPRD11719186 details