Entity Details

Primary name APLP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06481
EntryNameAPLP2_HUMAN
FullNameAmyloid-like protein 2
TaxID9606
Evidenceevidence at protein level
Length763
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesAPLP2

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0003677 DNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005634 nucleus
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008201 heparin binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031092 platelet alpha granule membrane
GO:0042802 identical protein binding
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0046914 transition metal ion binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR008154 Amyloidogenic glycoprotein, extracellularDomainDomain
IPR008155 Amyloidogenic glycoproteinFamilyFamily
IPR011178 Amyloidogenic glycoprotein, copper-bindingDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015849 Amyloidogenic glycoprotein, heparin-bindingDomainDomain
IPR019543 Beta-amyloid precursor protein C-terminalDomainDomain
IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved siteSiteConserved site
IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved siteSiteConserved site
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR024329 Amyloidogenic glycoprotein, E2 domainDomainDomain
IPR036176 E2 domain superfamilyFamilyHomologous superfamily
IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamilyFamilyHomologous superfamily
IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamilyFamilyHomologous superfamily
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
APLP2_HUMANAPBB1_HUMANBioGRID, HPRD, IntAct10081969 28514442 8855266 8894693 9461550 details
APLP2_HUMANAPBB3_HUMANBioGRID, HPRD, IntAct10081969 28514442 9461550 details
APLP2_HUMANZ512B_HUMANBioGRID, MINT15231748 details
APLP2_HUMANAPLP2_HUMANHPRD, IntAct16193067 8894693 details
APLP2_HUMANA4_HUMANIntAct16193067 32814053 details
APLP2_HUMANAPLP1_HUMANIntAct16193067 details
APLP2_HUMANETS1_HUMANBioGRID, IntAct20195357 details
APLP2_HUMANJUNB_HUMANBioGRID, IntAct20195357 details
APLP2_HUMANDEDD_HUMANBioGRID, IntAct20195357 details
APLP2_HUMANJUN_HUMANBioGRID, IntAct20195357 20936779 details
APLP2_HUMANMED12_HUMANMINT21293490 details
APLP2_HUMANRL26_HUMANBioGRID, IntAct21988832 details
APLP2_HUMANAPBA3_HUMANBioGRID, IntAct, UniProt26948053 28514442 details
APLP2_HUMANERP44_HUMANIntAct32814053 details
APLP2_HUMANUT14A_HUMANIntAct32814053 details
APLP2_HUMANTCOF_HUMANIntAct32814053 details
APLP2_HUMANSTX5_HUMANIntAct32814053 details
APLP2_HUMANSIAH1_HUMANIntAct32814053 details
APLP2_HUMANKS6B1_HUMANIntAct32814053 details
APLP2_HUMANSMAD3_HUMANIntAct32814053 details
APLP2_HUMANAPOE_HUMANIntAct32814053 details
APLP2_HUMANTM2D1_HUMANIntAct32814053 details
APLP2_HUMANPGCB_HUMANIntAct32814053 details
APLP2_HUMANMARK4_HUMANIntAct32814053 details
APLP2_HUMANBLMH_HUMANIntAct32814053 details
APLP2_HUMANFMR1_HUMANIntAct32814053 details
APLP2_HUMANFYN_HUMANIntAct32814053 details
APLP2_HUMANGFAP_HUMANIntAct32814053 details
APLP2_HUMANKPCA_HUMANHPRD, IntAct32814053 9109675 details
APLP2_HUMANS100B_HUMANIntAct32814053 details
APLP2_HUMANKSYK_HUMANIntAct32814053 details
APLP2_HUMANLRP8_HUMANIntAct32814053 details
APLP2_HUMANBRCA1_HUMANBioGRID11746496 details
APLP2_HUMANDAB2_HUMANBioGRID11247302 details
APLP2_HUMANDAB1_HUMANBioGRID, HPRD10460257 details
APLP2_HUMANHGS_HUMANBioGRID19019082 details
APLP2_HUMANKAT5_HUMANBioGRID14699153 details
APLP2_HUMANVKOR1_HUMANBioGRID21103663 details
APLP2_HUMANMK08_HUMANBioGRID12917434 details
APLP2_HUMANS13A1_HUMANBioGRID18407958 details
APLP2_HUMANAPBB2_HUMANBioGRID, HPRD, IntAct26186194 28514442 8855266 details
APLP2_HUMANSPON1_HUMANIntAct14983046 details
APLP2_HUMANNFKB1_HUMANIntAct20195357 details
APLP2_HUMANNKTR_HUMANBioGRID, IntAct27173435 unassigned1312 details
APLP2_HUMANAPBA2_HUMANIntAct31413325 details
APLP2_HUMAN1433S_HUMANBioGRID15778465 details
APLP2_HUMANHDAC5_HUMANBioGRID21081666 details
APLP2_HUMANBAG6_HUMANBioGRID22641691 details
APLP2_HUMANNMDZ1_HUMANBioGRID25683482 details
APLP2_HUMANNMDE2_HUMANBioGRID25683482 details
APLP2_HUMANNMDE1_HUMANBioGRID25683482 details
APLP2_HUMANAKT1_HUMANHPRD10490823 details
APLP2_HUMANPK3CA_HUMANHPRD10490823 details
APLP2_HUMANHLAA_HUMANHPRD19184004 details
APLP2_HUMANCDK1_HUMANHPRD9109675 details
APLP2_HUMANPRIO_HUMANHPRD15146195 details