Entity Details

Primary name PDE4D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08499
EntryNamePDE4D_HUMAN
FullNamecAMP-specific 3',5'-cyclic phosphodiesterase 4D
TaxID9606
Evidenceevidence at protein level
Length809
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPDE4D

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010469 regulation of signaling receptor activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0019933 cAMP-mediated signaling
GO:0030552 cAMP binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034704 calcium channel complex
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0044325 transmembrane transporter binding
GO:0045822 negative regulation of heart contraction
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0051117 ATPase binding
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:0097110 scaffold protein binding
GO:1901363 heterocyclic compound binding
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily
IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB01656 RoflumilastDrugbanksmall molecule
DB01791 PiclamilastDrugbanksmall molecule
DB01954 RolipramDrugbanksmall molecule
DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB02676 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-DiolDrugbanksmall molecule
DB02918 ZardaverineDrugbanksmall molecule
DB03183 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB03606 (S)-RolipramDrugbanksmall molecule
DB03849 CilomilastDrugbanksmall molecule
DB04149 (R)-RolipramDrugbanksmall molecule
DB04271 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB04469 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDrugbanksmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05266 IbudilastDrugbanksmall molecule
DB05298 TetomilastDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-oneDrugbanksmall molecule
DB07051 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTERDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule
DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
PDE4D_HUMANARRB2_HUMANBioGRID, DIP, IntAct, MINT14500724 17620599 19955404 20664520 details
PDE4D_HUMANKAPCA_HUMANBioGRID, HPRD, MINT20196770 20664520 8663227 9639573 details
PDE4D_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
PDE4D_HUMANCOIL_HUMANBioGRID, IntAct25416956 32296183 details
PDE4D_HUMANMAGA6_HUMANBioGRID, IntAct25416956 details
PDE4D_HUMANGOG8F_HUMANIntAct25416956 details
PDE4D_HUMANGOG8D_HUMANIntAct25416956 details
PDE4D_HUMANTRAF1_HUMANBioGRID, IntAct25416956 details
PDE4D_HUMANPCNA_HUMANUniProt26030842 details
PDE4D_HUMANOPTN_HUMANIntAct32814053 details
PDE4D_HUMANMYOME_HUMANBioGRID, HPRD11134006 details
PDE4D_HUMANPDE4D_HUMANBioGRID, HPRD12387865 details
PDE4D_HUMANRACK1_HUMANBioGRID, HPRD10329691 11516626 12193273 19372219 details
PDE4D_HUMANARRB1_HUMANBioGRID14500724 19372219 details
PDE4D_HUMANMDM2_HUMANBioGRID19372219 details
PDE4D_HUMANITSN1_HUMANBioGRID22558309 details
PDE4D_HUMANGSK3B_HUMANBioGRID20647544 details
PDE4D_HUMANKC1A_HUMANBioGRID20647544 details
PDE4D_HUMANLIS1_HUMANBioGRID21652625 details
PDE4D_HUMANA4_HUMANBioGRID21832049 details
PDE4D_HUMANLYN_HUMANBioGRID10571082 details
PDE4D_HUMANSRC_HUMANBioGRID10571082 details
PDE4D_HUMANFYN_HUMANBioGRID10571082 details
PDE4D_HUMANABL1_HUMANBioGRID10571082 details
PDE4D_HUMANGRB2_HUMANBioGRID10571082 details
PDE4D_HUMANPIAS4_HUMANBioGRID20196770 details
PDE4D_HUMANMK01_HUMANBioGRID20196770 details
PDE4D_HUMANSPTN1_HUMANBioGRID10571082 details
PDE4D_HUMANP85A_HUMANBioGRID10571082 details
PDE4D_HUMANTRI23_HUMANBioGRID21516116 details
PDE4D_HUMANFBX7_HUMANBioGRID27503909 details
PDE4D_HUMANRASH_HUMANBioGRID30655611 details
PDE4D_HUMANAKA12_HUMANBioGRID, MINT16642035 details
PDE4D_HUMANSHAN2_HUMANIntAct17244609 details
PDE4D_HUMANAKAP6_HUMANBioGRID, HPRD11296225 details
PDE4D_HUMANPP2BA_HUMANBioGRID20647544 details
PDE4D_HUMANPP2BB_HUMANBioGRID20647544 details
PDE4D_HUMANCANB1_HUMANBioGRID20647544 details
PDE4D_HUMANZBTB1_HUMANBioGRID24657165 details
PDE4D_HUMANATOH1_HUMANBioGRID27542412 details