Entity Details

Primary name KCNH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12809
EntryNameKCNH2_HUMAN
FullNamePotassium voltage-gated channel subfamily H member 2
TaxID9606
Evidenceevidence at protein level
Length1159
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesKCNH2

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0003064 regulation of heart rate by hormone
GO:0005242 inward rectifier potassium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009986 cell surface
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0055075 potassium ion homeostasis
GO:0055131 C3HC4-type RING finger domain binding
GO:0060048 cardiac muscle contraction
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0061337 cardiac conduction
GO:0071805 potassium ion transmembrane transport
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086009 membrane repolarization
GO:0086010 membrane depolarization during action potential
GO:0086011 membrane repolarization during action potential
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097110 scaffold protein binding
GO:0097623 potassium ion export across plasma membrane
GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1902937 inward rectifier potassium channel complex
GO:1903765 negative regulation of potassium ion export across plasma membrane
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000700 PAS-associated, C-terminalDomainDomain
IPR001610 PAC motifRepeatRepeat
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR003967 Potassium channel, voltage-dependent, ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00176 FluvoxamineDrugbanksmall molecule
DB00199 ErythromycinDrugbanksmall molecule
DB00204 DofetilideDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00276 AmsacrineDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00308 IbutilideDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00346 AlfuzosinDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00489 SotalolDrugbanksmall molecule
DB00537 CiprofloxacinDrugbanksmall molecule
DB00557 HydroxyzineDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01074 PerhexilineDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01162 TerazosinDrugbanksmall molecule
DB01182 PropafenoneDrugbanksmall molecule
DB01195 FlecainideDrugbanksmall molecule
DB01211 ClarithromycinDrugbanksmall molecule
DB01218 HalofantrineDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04957 AzimilideDrugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06217 VernakalantDrugbanksmall molecule
DB06457 TecastemizoleDrugbanksmall molecule
DB11090 Potassium nitrateDrugbanksmall molecule
DB11186 PentoxyverineDrugbanksmall molecule
DB11386 ChlorobutanolDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11642 PitolisantDrugbanksmall molecule
DB12364 BetrixabanDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
KCNH2_HUMANCDC73_HUMANBioGRID, HPRD, IntAct16169070 details
KCNH2_HUMANNDUS6_HUMANBioGRID, HPRD, IntAct16169070 details
KCNH2_HUMANPASK_HUMANMINT21418524 details
KCNH2_HUMANKCNH2_HUMANbhf-ucl, BioGRID, DIP, MINT19651618 24931372 29507111 8995352 details
KCNH2_HUMANCAV1_HUMANbhf-ucl18923542 details
KCNH2_HUMANFRMD8_HUMANBioGRID, IntAct32296183 details
KCNH2_HUMAN1433E_HUMANBioGRID, HPRD11953308 details
KCNH2_HUMANTARA_HUMANBioGRID29507111 details
KCNH2_HUMANRHOH_HUMANHPRD16169070 details
KCNH2_HUMANAG10B_HUMANBioGRID, HPRD14525949 details
KCNH2_HUMANKCNE1_HUMANBioGRID, HPRD9230439 details
KCNH2_HUMANHSP74_HUMANBioGRID12775586 29259226 details
KCNH2_HUMANHS90A_HUMANBioGRID12775586 17569659 23963841 29259226 details
KCNH2_HUMANCAV3_HUMANBioGRID22879586 details
KCNH2_HUMANNED4L_HUMANBioGRID22879586 24688054 details
KCNH2_HUMANCALX_HUMANBioGRID17569659 22242185 details
KCNH2_HUMANCALR_HUMANBioGRID22242185 details
KCNH2_HUMANHSP7C_HUMANBioGRID17569659 27998983 details
KCNH2_HUMANDNJA1_HUMANBioGRID17569659 details
KCNH2_HUMANSTIP1_HUMANBioGRID17569659 details
KCNH2_HUMANBAG2_HUMANBioGRID17569659 details
KCNH2_HUMANFKBP8_HUMANBioGRID17569659 details
KCNH2_HUMANRB11A_HUMANBioGRID23589291 details
KCNH2_HUMANCHIP_HUMANBioGRID23963841 27998983 details
KCNH2_HUMANRN207_HUMANBioGRID25281747 details
KCNH2_HUMANHS71A_HUMANBioGRID27998983 details
KCNH2_HUMANHS71B_HUMANBioGRID27998983 details
KCNH2_HUMANRN139_HUMANBioGRID27998983 details
KCNH2_HUMANRFFL_HUMANBioGRID30401747 details
KCNH2_HUMANSGMR1_HUMANBioGRID21680736 details
KCNH2_HUMANKCND3_HUMANBioGRID29259226 details
KCNH2_HUMAN1433F_HUMANHPRD11953308 details
KCNH2_HUMANKAPCA_HUMANHPRD10837251 11953308 details
KCNH2_HUMANKCNE2_HUMANHPRD11278781 details
KCNH2_HUMANAG10A_HUMANHPRD14525949 details