Entity Details

Primary name STK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13043
EntryNameSTK4_HUMAN
FullNameSerine/threonine-protein kinase 4
TaxID9606
Evidenceevidence at protein level
Length487
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSTK4

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000902 cell morphogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001841 neural tube formation
GO:0001934 positive regulation of protein phosphorylation
GO:0003157 endocardium development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0016604 nuclear body
GO:0018105 peptidyl-serine phosphorylation
GO:0030216 keratinocyte differentiation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043539 protein serine/threonine kinase activator activity
GO:0045600 positive regulation of fat cell differentiation
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060800 regulation of cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011524 SARAH domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR024205 Mst1 SARAH domainDomainDomain

Diseases

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Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
STK4_HUMANRASF5_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections11864565 15109305 16892067 17517604 20562859 20920251 23455922 24255178 24366813 24981860 details
STK4_HUMANRASF1_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections14729613 15109305 17598981 20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 26578655 28205554 28514442 details
STK4_HUMANSTK4_HUMANBioGRID, DIP, HPRD, IntAct11278782 12223493 17517604 20562859 21572393 22863277 23386615 26578655 28205554 8702870 details
STK4_HUMANSAV1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections16930133 17517604 20562859 20920251 23386615 23455922 24255178 24366813 24981860 25692647 26186194 27173435 28514442 30266805 unassigned1312 details
STK4_HUMANAKT1_HUMANBioGRID, MINT17932490 details
STK4_HUMANRASF2_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 28514442 details
STK4_HUMANRASF3_HUMANBioGRID, IntAct, Molecular Connections20920251 23455922 24255178 24366813 details
STK4_HUMANRASF4_HUMANBioGRID, IntAct, Molecular Connections20562859 20920251 23455922 24366813 details
STK4_HUMANRASF6_HUMANBioGRID, IntAct, Molecular Connections20920251 24366813 26186194 28514442 details
STK4_HUMANSTK3_HUMANBioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26344197 28205554 details
STK4_HUMANGBRAP_HUMANBioGRID, IntAct20562859 31857374 details
STK4_HUMANGBRL1_HUMANIntAct20562859 details
STK4_HUMANGBRL2_HUMANIntAct20562859 details
STK4_HUMANMLP3B_HUMANBioGRID, IntAct20562859 31857374 details
STK4_HUMANMLP3C_HUMANIntAct20562859 details
STK4_HUMANIL2RG_HUMANBioGRID, IntAct21988832 details
STK4_HUMANMOB1A_HUMANBioGRID, I2D, IntAct21516123 23386615 24255178 31941533 details
STK4_HUMANMOB1B_HUMANBioGRID, IntAct22863277 24255178 details
STK4_HUMANSLMAP_HUMANBioGRID, IntAct23386615 24255178 24366813 details
STK4_HUMANP52K_HUMANBioGRID, HPRD, IntAct12384512 24255178 details
STK4_HUMANPRDX1_HUMANIntAct23386615 details
STK4_HUMANPIHD1_HUMANIntAct23386615 details
STK4_HUMANPARVB_HUMANIntAct23386615 details
STK4_HUMANUBB_HUMANIntAct23386615 details
STK4_HUMANCSRP2_HUMANIntAct23386615 details
STK4_HUMANSPA5L_HUMANIntAct23386615 details
STK4_HUMANSODM_HUMANIntAct23386615 details
STK4_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
STK4_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
STK4_HUMANFOXO1_HUMANDIP18786403 details
STK4_HUMANH2B2E_HUMANBioGRID12757711 21572393 details
STK4_HUMANSIR1_HUMANBioGRID21212262 details
STK4_HUMANABL1_HUMANBioGRID21715626 details
STK4_HUMANH2AX_HUMANBioGRID20921231 details
STK4_HUMANNEDD4_HUMANBioGRID19953087 details
STK4_HUMANSMS1_HUMANBioGRID22863277 details
STK4_HUMANLATS2_HUMANBioGRID24255178 26578655 26898830 30266805 30865227 details
STK4_HUMANDAXX_HUMANBioGRID21572393 details
STK4_HUMANKEAP1_HUMANBioGRID30765703 details
STK4_HUMANRNF31_HUMANBioGRID30901564 details
STK4_HUMANMARK2_HUMANBioGRID31080060 details
STK4_HUMANOGT1_HUMANBioGRID32994395 details
STK4_HUMAN1433G_HUMANIntAct17353931 details
STK4_HUMANP53_HUMANBioGRID, HPRD, IntAct12384512 12942774 25241761 details
STK4_HUMANCASP3_HUMANBioGRID, HPRD, IntAct11278283 11278782 25241761 9545236 details
STK4_HUMANLATS1_HUMANHPRD, IntAct15688006 24012335 details
STK4_HUMANHSP7C_HUMANBioGRID, IntAct23386615 26657153 details
STK4_HUMANKIF3B_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANKIF3C_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANAKA12_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANDYRK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
STK4_HUMANFYN_HUMANIntAct31413325 details
STK4_HUMANCNKR1_HUMANBioGRID, HPRD15075335 details
STK4_HUMANFOXO3_HUMANBioGRID21715626 details
STK4_HUMANCT2NL_HUMANBioGRID24255178 details
STK4_HUMANFBW1B_HUMANBioGRID25332235 25515538 25900982 details
STK4_HUMANLTOR5_HUMANBioGRID26657153 details
STK4_HUMANHDAC6_HUMANBioGRID26657153 details
STK4_HUMANCUL7_HUMANBioGRID29632206 32252802 details
STK4_HUMANTRAF6_HUMANBioGRID30673917 details
STK4_HUMANAMOT_HUMANBioGRID30266805 details
STK4_HUMANCASA1_HUMANHPRD7665586 details
STK4_HUMANMBP_HUMANHPRD7665586 details