Entity Details

Primary name TIRAP
Entity type gene
Source Source Link

Details

PrimaryID114609
RefseqGeneNG_011523
SymbolTIRAP
NameTIR domain containing adaptor protein
Chromosome11
Location11q24.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-09-13
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTIRAP_HUMAN

GO terms

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GOName
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005080 protein kinase C binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0030099 myeloid cell differentiation
GO:0030139 endocytic vesicle
GO:0030674 protein-macromolecule adaptor activity
GO:0030890 positive regulation of B cell proliferation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032496 response to lipopolysaccharide
GO:0032587 ruffle membrane
GO:0032648 regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032738 positive regulation of interleukin-15 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

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Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
TIRAPMYD88BioGRID, DIP, HPRD, IntAct, MINT, UniProt11544529 17258210 17583698 18221795 20048342 21334391 24316379 28483816 details
TIRAPTIRAPBioGRID, HPIDb, IntAct11544529 17258210 24275656 details
TIRAPTLR4BioGRID, HPRD, IntAct11526399 11544529 17258210 18221795 20048342 21829704 21903422 details
TIRAPAPPBioGRID, IntAct21988832 details
TIRAPMPP3BioGRID, IntAct21988832 details
TIRAPPCNABioGRID, IntAct21988832 details
TIRAPLTN1BioGRID, IntAct21903422 details
TIRAPCCDC47BioGRID, IntAct21903422 details
TIRAPSAMHD1BioGRID, IntAct21903422 details
TIRAPARAFBioGRID, IntAct21903422 details
TIRAPIRAK1BioGRID, IntAct21903422 details
TIRAPIRAK4BioGRID, IntAct18221795 21903422 details
TIRAPCAPN1InnateDB23023391 details
TIRAPLRRK1BioGRID, IntAct24947832 29513927 details
TIRAPSARM1IntAct26592460 details
TIRAPTLR2BioGRID, IntAct17258210 18221795 details
TIRAPCASP1BioGRID, DIP17360653 20048342 details
TIRAPTMED7-TICAM2IntAct12721283 details
TIRAPTICAM2BioGRID, HPRD, IntAct12721283 details
TIRAPIRAK2BioGRID, HPRD, IntAct11544529 21903422 details
TIRAPPIK3R1MINT19574958 details
TIRAPSTT3AIntAct21903422 details
TIRAPAGERIntAct21829704 details
TIRAPRNF216BioGRID16968706 details
TIRAPSOCS1BioGRID, HPRD16415872 29991678 details
TIRAPTRAF6BioGRID, HPRD15247281 19592497 24084649 details
TIRAPBTKBioGRID, HPRD12724322 16415872 16439361 details
TIRAPKAT2ABioGRID23382074 details
TIRAPMAP3K7BioGRID24084649 details
TIRAPTAB1BioGRID24084649 details
TIRAPTNFSF9BioGRID24084649 details
TIRAPPIK3AP1BioGRID27909057 details
TIRAPEIF2AK2HPRD11526399 details
TIRAPCD247HPRD11572860 details
TIRAPTRAM1HPRD12721283 details
TIRAPDNAJC3HPRD11526399 details
TIRAPIL1RL1HPRD15004556 details
TIRAPPRKRAHPRD11526399 details
TIRAPTICAM1HPRD14517278 details
TIRAPUBR1BioGRID, IntAct21903422 details
TIRAPUBR2BioGRID, IntAct21903422 details
TIRAPRPTORBioGRID, IntAct21903422 details
TIRAPTAB2BioGRID, IntAct21903422 details
TIRAPSNRNP200BioGRID, IntAct21903422 details
TIRAPSTAT3BioGRID, IntAct21903422 details
TIRAPNF1BioGRID, IntAct21903422 details
TIRAPPDS5ABioGRID, IntAct21903422 details
TIRAPJAK1BioGRID, IntAct21903422 details
TIRAPNTMT1BioGRID, IntAct26186194 28514442 details
TIRAPTEP1BioGRID, IntAct26186194 28514442 details
TIRAPCAMK2DBioGRID, IntAct26186194 28514442 details
TIRAPCAMK2GBioGRID, IntAct26186194 28514442 details
TIRAPDHPSBioGRID, IntAct26186194 28514442 details
TIRAPBTBD9BioGRID26186194 details
TIRAPKLHL24BioGRID26186194 details