Entity Details

Primary name AAPK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13131
EntryNameAAPK1_HUMAN
FullName5'-AMP-activated protein kinase catalytic subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length559
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPRKAA1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001666 response to hypoxia
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0007165 signal transduction
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008610 lipid biosynthetic process
GO:0009411 response to UV
GO:0009631 cold acclimation
GO:0010332 response to gamma radiation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014823 response to activity
GO:0015721 bile acid and bile salt transport
GO:0016055 Wnt signaling pathway
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016324 apical plasma membrane
GO:0016607 nuclear speck
GO:0019395 fatty acid oxidation
GO:0030424 axon
GO:0030425 dendrite
GO:0031000 response to caffeine
GO:0031588 nucleotide-activated protein kinase complex
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0034599 cellular response to oxidative stress
GO:0035174 histone serine kinase activity
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0038183 bile acid signaling pathway
GO:0042149 cellular response to glucose starvation
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0046318 negative regulation of glucosylceramide biosynthetic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048156 tau protein binding
GO:0048511 rhythmic process
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0050321 tau-protein kinase activity
GO:0050405 [acetyl-CoA carboxylase] kinase activity
GO:0050995 negative regulation of lipid catabolic process
GO:0055089 fatty acid homeostasis
GO:0060627 regulation of vesicle-mediated transport
GO:0061744 motor behavior
GO:0061762 CAMKK-AMPK signaling cascade
GO:0062028 regulation of stress granule assembly
GO:0070050 neuron cellular homeostasis
GO:0070301 cellular response to hydrogen peroxide
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071277 cellular response to calcium ion
GO:0071333 cellular response to glucose stimulus
GO:0071361 cellular response to ethanol
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071456 cellular response to hypoxia
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120188 regulation of bile acid secretion
GO:1901563 response to camptothecin
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903109 positive regulation of mitochondrial transcription
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904428 negative regulation of tubulin deacetylation
GO:1904486 response to 17alpha-ethynylestradiol
GO:2000758 positive regulation of peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR028797 PRKAA1, UBA-like autoinhibitory domainDomainDomain
IPR032270 AMPK, C-terminal adenylate sensor domainDomainDomain
IPR039137 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00914 PhenforminDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
AAPK1_HUMANAAKB1_HUMANBioGRID, HPRD, IntAct, MINT16306228 18480843 20562859 21232561 22363791 22939629 23455922 25852190 26344197 28514442 31900314 8621713 8626596 8663446 details
AAPK1_HUMANAAKB2_HUMANBioGRID, HPRD, IntAct16306228 20562859 21988832 22363791 23455922 24722188 25416956 25852190 26344197 28514442 31900314 8626596 details
AAPK1_HUMANAAKG1_HUMANBioGRID, HPRD, IntAct10698692 16306228 20562859 21232561 22363791 23455922 25416956 25852190 26186194 28514442 31515488 31900314 8621713 8663446 details
AAPK1_HUMANULK1_HUMANBioGRID, DIP, IntAct20562859 21072212 21460634 25686248 details
AAPK1_HUMANGATA1_HUMANBioGRID, IntAct21988832 details
AAPK1_HUMANMORC4_HUMANBioGRID, IntAct21988832 details
AAPK1_HUMANPKHA4_HUMANBioGRID, IntAct21988832 31091453 details
AAPK1_HUMANPPM1F_HUMANBioGRID, MINT20801214 details
AAPK1_HUMANSTK11_HUMANBioGRID, MINT16912160 22575644 31217475 31995728 details
AAPK1_HUMANACACA_HUMANBioGRID, HPRD, IntAct11052978 18480843 23455922 2900138 7907095 details
AAPK1_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
AAPK1_HUMANBHE40_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANCDX4_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANFSBP_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANZBED1_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANTRI27_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANTLE5_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANGOGA2_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANCTBP1_HUMANBioGRID, IntAct25416956 31515488 details
AAPK1_HUMANTRIP6_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANMTUS2_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANUBX11_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANHMBX1_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANRFX6_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANHOMEZ_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANPHC2_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANVPS52_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANIN80E_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANLMBL3_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANPNMA5_HUMANBioGRID, IntAct25416956 31515488 details
AAPK1_HUMANVP37B_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANROP1A_HUMANBioGRID, IntAct25416956 31515488 details
AAPK1_HUMANTHAP1_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANABI2_HUMANBioGRID, IntAct25416956 29892012 details
AAPK1_HUMANRIM3A_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANIKZF3_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANADIP_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANT22D4_HUMANBioGRID, IntAct25416956 details
AAPK1_HUMANKI16B_HUMANBioGRID, IntAct27107012 details
AAPK1_HUMANAAKG3_HUMANBioGRID, HPRD, IntAct28514442 31900314 8626596 details
AAPK1_HUMANMYL9_HUMANDIP17486097 details
AAPK1_HUMANMTOR_HUMANBioGRID, HPRD14970221 details
AAPK1_HUMANTSC2_HUMANBioGRID14651849 15261145 28059666 details
AAPK1_HUMANFNIP1_HUMANBioGRID17028174 details
AAPK1_HUMANCFTR_HUMANBioGRID, HPRD10862786 20861072 details
AAPK1_HUMANPP2AA_HUMANBioGRID16306228 22065577 details
AAPK1_HUMANPSD11_HUMANBioGRID19616115 details
AAPK1_HUMANCRBN_HUMANBioGRID21232561 details
AAPK1_HUMANEPM2A_HUMANBioGRID21728993 details
AAPK1_HUMANRPTOR_HUMANBioGRID18439900 details
AAPK1_HUMANHDAC5_HUMANBioGRID22462548 details
AAPK1_HUMANCRTC2_HUMANBioGRID22462548 details
AAPK1_HUMANTOM34_HUMANBioGRID, HPRD11913976 details
AAPK1_HUMANM3K7_HUMANBioGRID20538596 20615388 31995728 details
AAPK1_HUMANMDM4_HUMANBioGRID24190973 details
AAPK1_HUMANRA54B_HUMANBioGRID25416956 details
AAPK1_HUMANTXNIP_HUMANBioGRID23453806 details
AAPK1_HUMANPPM1E_HUMANBioGRID20801214 details
AAPK1_HUMANPPM1A_HUMANBioGRID20801214 details
AAPK1_HUMANKKCC1_HUMANBioGRID20801214 details
AAPK1_HUMANDVL2_HUMANBioGRID21516116 details
AAPK1_HUMANUBP10_HUMANBioGRID26876938 30056112 details
AAPK1_HUMANFANCA_HUMANBioGRID27449087 details
AAPK1_HUMANPASK_HUMANBioGRID22065581 details
AAPK1_HUMANCHK1_HUMANBioGRID30428154 details
AAPK1_HUMANRACK1_HUMANBioGRID24166503 26549445 details
AAPK1_HUMANAGAP2_HUMANBioGRID30833542 details
AAPK1_HUMANHS90A_HUMANBioGRID, IntAct16306228 22939624 23455922 details
AAPK1_HUMANCDC37_HUMANBioGRID, IntAct16306228 25036637 details
AAPK1_HUMANHS90B_HUMANBioGRID, IntAct22939624 23455922 details
AAPK1_HUMANDCR1C_HUMANBioGRID, IntAct26186194 28514442 31900314 details
AAPK1_HUMANYAP1_HUMANDIP25751139 25751140 details
AAPK1_HUMANFYN_HUMANIntAct31413325 details
AAPK1_HUMANHSP74_HUMANBioGRID16306228 details
AAPK1_HUMANTBA1A_HUMANBioGRID16306228 details
AAPK1_HUMANSIK3_HUMANBioGRID16306228 details
AAPK1_HUMAN1433Z_HUMANBioGRID16306228 details
AAPK1_HUMAN1433E_HUMANBioGRID16306228 details
AAPK1_HUMANSIK1_HUMANBioGRID16306228 details
AAPK1_HUMANSIK2_HUMANBioGRID16306228 details
AAPK1_HUMANTERA_HUMANBioGRID16306228 details
AAPK1_HUMAN2AAB_HUMANBioGRID16306228 details
AAPK1_HUMANUBP2_HUMANBioGRID16306228 details
AAPK1_HUMANNUAK1_HUMANBioGRID16306228 details
AAPK1_HUMANNUAK2_HUMANBioGRID16306228 details
AAPK1_HUMANBRSK1_HUMANBioGRID16306228 details
AAPK1_HUMANBRSK2_HUMANBioGRID16306228 details
AAPK1_HUMANMARK1_HUMANBioGRID16306228 details
AAPK1_HUMANMARK2_HUMANBioGRID16306228 details
AAPK1_HUMANMARK3_HUMANBioGRID16306228 details
AAPK1_HUMANMARK4_HUMANBioGRID16306228 details
AAPK1_HUMANSNRK_HUMANBioGRID16306228 details
AAPK1_HUMANPRGC1_HUMANBioGRID24371122 details
AAPK1_HUMANPPARG_HUMANBioGRID18674809 details
AAPK1_HUMANEP300_HUMANBioGRID21567395 details
AAPK1_HUMANINSR_HUMANBioGRID25687571 details
AAPK1_HUMANFANCG_HUMANBioGRID27449087 details
AAPK1_HUMANGLI1_HUMANBioGRID28562331 details
AAPK1_HUMANSHC1_HUMANBioGRID30109811 details
AAPK1_HUMANMLP3A_HUMANBioGRID30109811 details
AAPK1_HUMANINSI1_HUMANBioGRID30733434 details
AAPK1_HUMANBRD4_HUMANBioGRID29172540 details
AAPK1_HUMANP53_HUMANBioGRID29172540 details
AAPK1_HUMANBECN1_HUMANBioGRID27304906 details
AAPK1_HUMANSYPM_HUMANBioGRID31900314 details
AAPK1_HUMANENTR1_HUMANBioGRID31900314 details
AAPK1_HUMANCDK4_HUMANBioGRID30833542 details
AAPK1_HUMANAXIN1_HUMANBioGRID31995728 details
AAPK1_HUMANKKCC2_HUMANBioGRID31995728 details
AAPK1_HUMANTULP3_HUMANBioGRID33187986 details
AAPK1_HUMANMAGAB_HUMANBioGRID33004795 details
AAPK1_HUMANF262_HUMANHPRD12853467 1322130 details
AAPK1_HUMANEF2K_HUMANHPRD11171059 11500364 14709557 15024086 details
AAPK1_HUMANCAB39_HUMANHPRD8910387 details
AAPK1_HUMANGRIK2_HUMANHPRD8094892 8163463 details
AAPK1_HUMANRAF1_HUMANHPRD11971957 9091312 9710607 details