Entity Details

Primary name MK07_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13164
EntryNameMK07_HUMAN
FullNameMitogen-activated protein kinase 7
TaxID9606
Evidenceevidence at protein level
Length816
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK7

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019933 cAMP-mediated signaling
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0045765 regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0051019 mitogen-activated protein kinase binding
GO:0051247 positive regulation of protein metabolic process
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
MK07_HUMANMP2K5_HUMANBioGRID, IntAct24975362 28514442 32296183 7759517 details
MK07_HUMAN1433B_HUMANBioGRID, HPRD, MINT14679215 details
MK07_HUMANPML_HUMANBioGRID, IntAct20832753 22869143 details
MK07_HUMANGOGB1_HUMANBioGRID, IntAct20936779 details
MK07_HUMANMEF2C_HUMANBioGRID, HPRD, IntAct20936779 9384584 9753748 details
MK07_HUMANNR1I2_HUMANBioGRID, IntAct21988832 details
MK07_HUMANSH22A_HUMANBioGRID, IntAct21988832 details
MK07_HUMANFGF21_HUMANBioGRID, IntAct21988832 details
MK07_HUMANMACIR_HUMANBioGRID, IntAct21988832 details
MK07_HUMANEGLN3_HUMANBioGRID, IntAct21988832 details
MK07_HUMANZB6CL_HUMANBioGRID, IntAct21988832 details
MK07_HUMANACTN4_HUMANBioGRID, IntAct21988832 details
MK07_HUMANMEF2A_HUMANBioGRID, HPRD, IntAct10849446 26871637 9753748 9858528 details
MK07_HUMANUBE2C_HUMANBioGRID, IntAct25416956 32296183 details
MK07_HUMANZKSC1_HUMANBioGRID, IntAct32296183 details
MK07_HUMANCCDC6_HUMANBioGRID, IntAct32296183 details
MK07_HUMAN1433E_HUMANBioGRID14679215 23428871 details
MK07_HUMANCXA1_HUMANBioGRID, HPRD12637502 8631994 9535905 9535909 details
MK07_HUMANSGK1_HUMANBioGRID, HPRD11254654 details
MK07_HUMANPTPRR_HUMANBioGRID, HPRD12042304 details
MK07_HUMANRAF1_HUMANBioGRID, HPRD10531364 details
MK07_HUMANMEF2D_HUMANBioGRID, HPRD10849446 9753748 details
MK07_HUMANMK07_HUMANBioGRID23602568 31980649 7759517 details
MK07_HUMANFOS_HUMANBioGRID17018293 details
MK07_HUMANETS1_HUMANBioGRID, HPRD11948414 12048211 details
MK07_HUMANA4_HUMANBioGRID21244100 21832049 details
MK07_HUMANNF2L2_HUMANBioGRID23043106 details
MK07_HUMANKPCZ_HUMANBioGRID20538799 details
MK07_HUMANGPSM3_HUMANBioGRID21516116 details
MK07_HUMANHS90B_HUMANBioGRID, IntAct22939624 23428871 details
MK07_HUMANCDC37_HUMANBioGRID, IntAct23428871 25036637 details
MK07_HUMANBAG2_HUMANBioGRID, IntAct31980649 details
MK07_HUMANFXR1_HUMANMINT21653829 details
MK07_HUMANHS90A_HUMANBioGRID22939624 details
MK07_HUMANBAG3_HUMANBioGRID23824909 details
MK07_HUMANP53_HUMANBioGRID22869143 details
MK07_HUMANM3K2_HUMANBioGRID24975362 details
MK07_HUMANRXRA_HUMANHPRD12048211 details
MK07_HUMANMYC_HUMANHPRD9461566 details
MK07_HUMANELK4_HUMANHPRD10473620 details