Entity Details

Primary name TBX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13207
EntryNameTBX2_HUMAN
FullNameT-box transcription factor TBX2
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTBX2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001708 cell fate specification
GO:0001947 heart looping
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003272 endocardial cushion formation
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007521 muscle cell fate determination
GO:0007569 cell aging
GO:0008016 regulation of heart contraction
GO:0008284 positive regulation of cell population proliferation
GO:0035050 embryonic heart tube development
GO:0035909 aorta morphogenesis
GO:0036302 atrioventricular canal development
GO:0042733 embryonic digit morphogenesis
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0051145 smooth muscle cell differentiation
GO:0060021 roof of mouth development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060465 pharynx development
GO:0060560 developmental growth involved in morphogenesis
GO:0060596 mammary placode formation
GO:0072105 ureteric peristalsis
GO:0090398 cellular senescence
GO:1901208 negative regulation of heart looping
GO:1901211 negative regulation of cardiac chamber formation
GO:1905072 cardiac jelly development
GO:1905222 atrioventricular canal morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001699 Transcription factor, T-boxFamilyFamily
IPR002070 Transcription factor, BrachyuryFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR018186 Transcription factor, T-box, conserved siteSiteConserved site
IPR022582 Transcription factor, T-box, region of unknown functionDomainDomain
IPR036960 T-box superfamilyFamilyHomologous superfamily

Diseases

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