Entity Details

Primary name SRSF6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13247
EntryNameSRSF6_HUMAN
FullNameSerine/arginine-rich splicing factor 6
TaxID9606
Evidenceevidence at protein level
Length344
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesSRSF6

GO terms

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GOName
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005654 nucleoplasm
GO:0006376 mRNA splice site selection
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0010837 regulation of keratinocyte proliferation
GO:0016607 nuclear speck
GO:0031124 mRNA 3'-end processing
GO:0032868 response to insulin
GO:0036002 pre-mRNA binding
GO:0045617 negative regulation of keratinocyte differentiation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060548 negative regulation of cell death
GO:0061041 regulation of wound healing
GO:2000675 negative regulation of type B pancreatic cell apoptotic process

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR029541 Serine/arginine-rich splicing factor 6FamilyFamily
IPR034511 SRSF6, RNA recognition motif 1DomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
SRSF6_HUMANRNPS1_HUMANBioGRID, HPRD, IntAct16189514 26344197 31515488 details
SRSF6_HUMANSRSF4_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
SRSF6_HUMANSF3B4_HUMANBioGRID, MINT22365833 details
SRSF6_HUMANRBM10_HUMANBioGRID, MINT22365833 details
SRSF6_HUMANTRA2B_HUMANBioGRID, MINT22365833 24981860 26344197 details
SRSF6_HUMANTOE1_HUMANBioGRID, MINT22365833 details
SRSF6_HUMANSRPK2_HUMANBioGRID, IntAct23602568 26167880 9472028 details
SRSF6_HUMANSRPK1_HUMANBioGRID, HPRD, IntAct10340541 23602568 8208298 details
SRSF6_HUMANLC7L2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
SRSF6_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
SRSF6_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
SRSF6_HUMANLUC7L_HUMANBioGRID, IntAct32296183 details
SRSF6_HUMANSREK1_HUMANBioGRID, HPRD10757789 14559993 details
SRSF6_HUMANA4_HUMANBioGRID21832049 details
SRSF6_HUMANCLK1_HUMANBioGRID, HPRD12549978 26167880 details
SRSF6_HUMANOGT1_HUMANBioGRID32994395 details
SRSF6_HUMAN1433G_HUMANIntAct17353931 details
SRSF6_HUMANCNBP_HUMANIntAct17353931 details
SRSF6_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
SRSF6_HUMANPR38A_HUMANBioGRID, IntAct27173435 unassigned1312 details
SRSF6_HUMANSRSF3_HUMANBioGRID, IntAct26344197 27173435 unassigned1312 details
SRSF6_HUMANSRSF5_HUMANBioGRID, IntAct27173435 unassigned1312 details
SRSF6_HUMANNCBP2_HUMANBioGRID, IntAct29395067 32960270 details
SRSF6_HUMANPRGC1_HUMANBioGRID, HPRD10983978 details
SRSF6_HUMANSRRM1_HUMANBioGRID10809668 16159877 details
SRSF6_HUMAN1433E_HUMANBioGRID19608861 details
SRSF6_HUMANU2AF2_HUMANBioGRID26641092 details