Entity Details

Primary name ATM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13315
EntryNameATM_HUMAN
FullNameSerine-protein kinase ATM
TaxID9606
Evidenceevidence at protein level
Length3056
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesATM

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000425 pexophagy
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001756 somitogenesis
GO:0002331 pre-B cell allelic exclusion
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004677 DNA-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005819 spindle
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiotic nuclear division
GO:0007143 female meiotic nuclear division
GO:0007165 signal transduction
GO:0007420 brain development
GO:0007507 heart development
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791 post-embryonic development
GO:0010212 response to ionizing radiation
GO:0010506 regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0033129 positive regulation of histone phosphorylation
GO:0033151 V(D)J recombination
GO:0035264 multicellular organism growth
GO:0036289 peptidyl-serine autophosphorylation
GO:0042159 lipoprotein catabolic process
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045141 meiotic telomere clustering
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0051402 neuron apoptotic process
GO:0071044 histone mRNA catabolic process
GO:0071300 cellular response to retinoic acid
GO:0071480 cellular response to gamma radiation
GO:0071481 cellular response to X-ray
GO:0071500 cellular response to nitrosative stress
GO:0090399 replicative senescence
GO:0097694 establishment of RNA localization to telomere
GO:0097695 establishment of protein-containing complex localization to telomere
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903626 positive regulation of DNA catabolic process
GO:1903978 regulation of microglial cell activation
GO:1904262 negative regulation of TORC1 signaling
GO:1904354 negative regulation of telomere capping
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1904884 positive regulation of telomerase catalytic core complex assembly
GO:1905843 regulation of cellular response to gamma radiation
GO:1990391 DNA repair complex

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014009 PIK-related kinaseDomainDomain
IPR015519 Serine/threonine-protein kinase ATM/Tel1FamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR021668 Telomere-length maintenance and DNA damage repairDomainDomain
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR044107 ATM, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule

Interactions

169 interactions

InteractorPartnerSourcesPublicationsLink
ATM_HUMANP53_HUMANBioGRID, HPRD, MINT10608806 10673501 10713094 10744722 10864201 11459832 11551930 11709713 11875057 14744854 15064416 15159397 15632067 15713674 15790808 16858402 17157788 17409407 19965871 20010693 21383020 23907539 24469230 25086746 27559048 30252118 9765199 9843217 details
ATM_HUMANMDC1_HUMANBioGRID, HPRD, UniProt12607005 14519663 18006705 26734725 28943310 29656893 details
ATM_HUMANH2AX_HUMANBioGRID, DIP, HPRD, MINT11571274 11893489 16858402 18344987 21676867 21704408 22184063 22451927 26095369 27918549 32518374 9488723 details
ATM_HUMANABL1_HUMANBioGRID, DIP, HPRD, IntAct10212258 11375976 17409407 20798688 9168116 9168117 details
ATM_HUMANTERF1_HUMANBioGRID, DIP, HPRD, IntAct11375976 15314656 18160036 details
ATM_HUMANAATF_HUMANHPRD, IntAct17157788 details
ATM_HUMANPP1A_HUMANBioGRID, IntAct17274640 details
ATM_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
ATM_HUMANTELO2_HUMANBioGRID, IntAct, UniProt18160036 20427287 20801936 details
ATM_HUMANSMC1A_HUMANBioGRID, HPRD, UniProt11877376 11877377 details
ATM_HUMANSOSB1_HUMANUniProt18449195 details
ATM_HUMANNEMO_HUMANBioGRID, MINT16497931 18583959 24457965 28202068 30254148 32731169 details
ATM_HUMANATM_HUMANBioGRID, HPRD, IntAct10608806 12556884 14519663 15790808 16858402 16906133 18571408 20360068 details
ATM_HUMANTP53B_HUMANBioGRID, HPRD, IntAct, UniProt11042216 12447390 12697768 18996087 20010693 22621922 29656893 details
ATM_HUMAN2A5G_HUMANBioGRID, I2D21460856 details
ATM_HUMANACL6B_HUMANBioGRID, MINT25640309 details
ATM_HUMANMAP1S_HUMANBioGRID, MINT25640309 details
ATM_HUMANNREP_HUMANBioGRID, MINT25640309 details
ATM_HUMANHEMH_HUMANBioGRID, MINT25640309 details
ATM_HUMANHSP7C_HUMANBioGRID, MINT25640309 details
ATM_HUMANZN821_HUMANBioGRID, MINT25640309 details
ATM_HUMANNU4M_HUMANBioGRID, MINT25640309 details
ATM_HUMANNR4A1_HUMANBioGRID, MINT25640309 details
ATM_HUMANNSD3_HUMANBioGRID, MINT25640309 details
ATM_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
ATM_HUMANERRFI_HUMANBioGRID, MINT25640309 details
ATM_HUMANMTA3_HUMANBioGRID, MINT25640309 details
ATM_HUMANIL24_HUMANBioGRID, MINT25640309 details
ATM_HUMANARY2_HUMANBioGRID, MINT25640309 details
ATM_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
ATM_HUMANTFF1_HUMANBioGRID, MINT25640309 details
ATM_HUMANERR3_HUMANBioGRID, IntAct32296183 details
ATM_HUMANTERF2_HUMANBioGRID, DIP15314656 details
ATM_HUMANRIR2B_HUMANBioGRID, DIP19015526 details
ATM_HUMANFBX31_HUMANDIP19412162 details
ATM_HUMANNOTC1_HUMANDIP25895060 details
ATM_HUMANNBN_HUMANBioGRID, DIP, HPRD10608806 10783165 10839544 10839545 11252893 15758953 17507690 22464731 24800743 25088203 25895060 30952868 details
ATM_HUMANPEX5_HUMANBioGRID, DIP, HPRD10567403 26344566 details
ATM_HUMANBRCA1_HUMANBioGRID, HPRD, UniProt10550055 10608806 10783165 10866324 11114888 15713674 17478428 18344987 29656893 details
ATM_HUMANNF2L2_HUMANIntAct32911434 details
ATM_HUMANCTIP_HUMANBioGRID, HPRD10608806 10910365 11689934 22544744 23468639 details
ATM_HUMANFACD2_HUMANBioGRID, HPRD12086603 14499622 details
ATM_HUMANBLM_HUMANBioGRID10783165 12034743 29523790 details
ATM_HUMANAP1B1_HUMANBioGRID, HPRD10608806 9707615 details
ATM_HUMANATR_HUMANBioGRID10608806 17124492 details
ATM_HUMANPRKDC_HUMANBioGRID, HPRD10464290 10608806 details
ATM_HUMANCHK1_HUMANBioGRID, HPRD10608806 11252893 11390642 12676583 details
ATM_HUMANE4F1_HUMANBioGRID10608806 details
ATM_HUMAN4EBP1_HUMANBioGRID, HPRD10608806 10713094 11146653 12588975 9806882 details
ATM_HUMANDNLI4_HUMANBioGRID10608806 details
ATM_HUMANMRE11_HUMANBioGRID, HPRD10608806 10783165 15758953 details
ATM_HUMANRAD17_HUMANBioGRID, HPRD10608806 11418864 18344987 details
ATM_HUMANWRN_HUMANBioGRID, HPRD10608806 10839545 11252893 details
ATM_HUMANBRCA2_HUMANBioGRID15199141 details
ATM_HUMANMCM2_HUMANBioGRID15210935 details
ATM_HUMANRHEB_HUMANBioGRID, HPRD15854902 details
ATM_HUMANCDC6_HUMANBioGRID20048340 details
ATM_HUMANCXXC5_HUMANBioGRID19557330 details
ATM_HUMANMCPH1_HUMANBioGRID16872911 25301947 details
ATM_HUMANDDX1_HUMANBioGRID18710941 details
ATM_HUMANKAT8_HUMANBioGRID15923642 details
ATM_HUMANATF2_HUMANBioGRID15916964 18397884 details
ATM_HUMANFOXO3_HUMANBioGRID18344987 details
ATM_HUMANHDAC1_HUMANBioGRID10531300 details
ATM_HUMANCHK2_HUMANBioGRID, HPRD10713094 10744722 10973490 11901158 12024051 12242661 12493754 15064416 15790808 16794575 20010693 details
ATM_HUMANPARP1_HUMANBioGRID17428792 details
ATM_HUMANCHD4_HUMANBioGRID21219611 details
ATM_HUMANEXO1_HUMANBioGRID20019063 details
ATM_HUMANE2F1_HUMANBioGRID, HPRD11459832 details
ATM_HUMANDYRK2_HUMANBioGRID19965871 details
ATM_HUMANTRAF6_HUMANBioGRID20932475 details
ATM_HUMANTCL1A_HUMANBioGRID22065599 details
ATM_HUMANXRCC5_HUMANBioGRID, HPRD15758953 17171639 details
ATM_HUMANATRIP_HUMANBioGRID, HPRD15758953 details
ATM_HUMANBRE1A_HUMANBioGRID21362549 details
ATM_HUMANBRE1B_HUMANBioGRID21362549 details
ATM_HUMANEIF3E_HUMANBioGRID22508697 details
ATM_HUMANDCAF1_HUMANBioGRID22184063 details
ATM_HUMANDCR1C_HUMANBioGRID, HPRD15456891 details
ATM_HUMANTOPB1_HUMANBioGRID, HPRD11756551 19023333 details
ATM_HUMANMDM2_HUMANBioGRID, HPRD11331603 22976441 27462439 30252118 details
ATM_HUMANKC1D_HUMANBioGRID22976441 details
ATM_HUMANSOCS1_HUMANBioGRID20005840 29991678 details
ATM_HUMANTOP1_HUMANBioGRID12549820 details
ATM_HUMANXPA_HUMANBioGRID, HPRD16540648 details
ATM_HUMANCDN2C_HUMANBioGRID15680327 details
ATM_HUMANDAXX_HUMANBioGRID23405218 details
ATM_HUMANSPSB1_HUMANBioGRID18449195 details
ATM_HUMANRFA1_HUMANBioGRID10713094 details
ATM_HUMANRFA2_HUMANBioGRID10713094 details
ATM_HUMANBCL10_HUMANBioGRID24732096 details
ATM_HUMANRPB1_HUMANBioGRID24957606 9168116 details
ATM_HUMANHIF1A_HUMANBioGRID21095582 details
ATM_HUMANCREB1_HUMANBioGRID, HPRD15073328 16293623 details
ATM_HUMANZEB1_HUMANBioGRID25086746 details
ATM_HUMANRASF1_HUMANBioGRID10608806 details
ATM_HUMANAP3B1_HUMANBioGRID10608806 details
ATM_HUMANBANP_HUMANBioGRID25299772 details
ATM_HUMANRANB9_HUMANBioGRID26943034 details
ATM_HUMANUCHL3_HUMANBioGRID27941124 details
ATM_HUMANCSN5_HUMANBioGRID24710276 details
ATM_HUMANCRX_HUMANBioGRID27107012 details
ATM_HUMANPTC1_HUMANBioGRID15142440 details
ATM_HUMANTRI29_HUMANBioGRID26095369 details
ATM_HUMANPAN2_HUMANBioGRID33097710 details
ATM_HUMANAP2B1_HUMANHPRD9707615 details
ATM_HUMANAP3B2_HUMANHPRD9707615 details
ATM_HUMANVHL_HUMANBioGRID, IntAct16678111 17353931 details
ATM_HUMANATMIN_HUMANBioGRID, MINT17525732 25092319 details
ATM_HUMANRNF8_HUMANIntAct18001825 details
ATM_HUMANTYDP1_HUMANBioGRID, MINT17478428 19851285 details
ATM_HUMANTTI1_HUMANBioGRID, UniProt20427287 20810650 details
ATM_HUMANBRAT1_HUMANBioGRID, IntAct16452482 details
ATM_HUMANMLH1_HUMANBioGRID10783165 details
ATM_HUMANMSH2_HUMANBioGRID10783165 details
ATM_HUMANMSH6_HUMANBioGRID10783165 details
ATM_HUMANRAD50_HUMANBioGRID10783165 details
ATM_HUMANRAD51_HUMANBioGRID, HPRD10212258 details
ATM_HUMANRFC1_HUMANBioGRID10783165 details
ATM_HUMANXPC_HUMANBioGRID19805520 23422745 details
ATM_HUMANSNF5_HUMANBioGRID19805520 details
ATM_HUMANHUWE1_HUMANBioGRID17478428 22213803 details
ATM_HUMANUBP34_HUMANBioGRID17478428 details
ATM_HUMANMED1_HUMANBioGRID17478428 details
ATM_HUMANFANCI_HUMANBioGRID17478428 details
ATM_HUMANSMC3_HUMANBioGRID17478428 details
ATM_HUMANTAOK3_HUMANBioGRID17478428 details
ATM_HUMANDCR1A_HUMANBioGRID18848520 details
ATM_HUMANHNRL1_HUMANBioGRID18480432 details
ATM_HUMANBMI1_HUMANBioGRID20668194 21676867 details
ATM_HUMANSRBP1_HUMANBioGRID20534441 details
ATM_HUMANKAT5_HUMANBioGRID, HPRD16141325 19783983 21704408 details
ATM_HUMANSKP2_HUMANBioGRID22464731 details
ATM_HUMANM3K7_HUMANBioGRID21606198 32731169 details
ATM_HUMANPTPA_HUMANBioGRID16452482 details
ATM_HUMANSMAD7_HUMANBioGRID17172861 details
ATM_HUMANMK14_HUMANBioGRID17172861 details
ATM_HUMANHLAA_HUMANBioGRID20064447 details
ATM_HUMANSPOP_HUMANBioGRID24451148 details
ATM_HUMANTIF1B_HUMANBioGRID23096706 28249048 details
ATM_HUMANMAGC2_HUMANBioGRID23096706 details
ATM_HUMANTF65_HUMANBioGRID24957606 details
ATM_HUMANCDK9_HUMANBioGRID24957606 details
ATM_HUMANWWOX_HUMANBioGRID25331887 26675548 details
ATM_HUMANKDM2A_HUMANBioGRID25823024 details
ATM_HUMANSNAI1_HUMANBioGRID28067227 details
ATM_HUMANFOXO1_HUMANBioGRID27559048 details
ATM_HUMANNOP53_HUMANBioGRID27829214 details
ATM_HUMANRL5_HUMANBioGRID30252118 details
ATM_HUMANRL11_HUMANBioGRID30252118 details
ATM_HUMANAVEN_HUMANBioGRID18571408 details
ATM_HUMANTRI37_HUMANBioGRID30254148 details
ATM_HUMANSTK11_HUMANBioGRID, HPRD11853558 12234250 15713674 details
ATM_HUMANSIM2_HUMANBioGRID30531838 details
ATM_HUMANRSF1_HUMANBioGRID24800743 details
ATM_HUMANSMCA5_HUMANBioGRID24800743 details
ATM_HUMANBAZ1A_HUMANBioGRID24800743 details
ATM_HUMANBAZ1B_HUMANBioGRID24800743 details
ATM_HUMANPELI1_HUMANBioGRID30952868 details
ATM_HUMANCBL_HUMANBioGRID31315051 details
ATM_HUMANUBP28_HUMANBioGRID31938050 details
ATM_HUMANTOP2B_HUMANBioGRID32015321 details
ATM_HUMANPRKN_HUMANBioGRID32029507 details
ATM_HUMANIKKB_HUMANBioGRID32731169 details
ATM_HUMANIKKA_HUMANBioGRID32731169 details
ATM_HUMANRAD9A_HUMANHPRD11278446 12709442 details
ATM_HUMANPARPT_HUMANHPRD11238919 details
ATM_HUMANMCA3_HUMANHPRD15680327 details
ATM_HUMANMDM4_HUMANHPRD15788536 16163388 details