Entity Details

Primary name PTPRS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13332
EntryNamePTPRS_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase S
TaxID9606
Evidenceevidence at protein level
Length1948
SequenceStatuscomplete
DateCreated2003-07-19
DateModified2021-06-02

Ontological Relatives

GenesPTPRS

GO terms

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GOName
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006470 protein dephosphorylation
GO:0008201 heparin binding
GO:0010977 negative regulation of neuron projection development
GO:0021510 spinal cord development
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0022038 corpus callosum development
GO:0030285 integral component of synaptic vesicle membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0030517 negative regulation of axon extension
GO:0032687 negative regulation of interferon-alpha production
GO:0032688 negative regulation of interferon-beta production
GO:0034164 negative regulation of toll-like receptor 9 signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035374 chondroitin sulfate binding
GO:0043204 perikaryon
GO:0043395 heparan sulfate proteoglycan binding
GO:0048671 negative regulation of collateral sprouting
GO:0048681 negative regulation of axon regeneration
GO:0050804 modulation of chemical synaptic transmission
GO:0061000 negative regulation of dendritic spine development
GO:0070062 extracellular exosome
GO:0090557 establishment of endothelial intestinal barrier
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099151 regulation of postsynaptic density assembly
GO:0099560 synaptic membrane adhesion

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle
Perikaryon

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00630 Alendronic acidDrugbanksmall molecule
DB01077 Etidronic acidDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
PTPRS_HUMANPTPRS_HUMANMINT15978577 details
PTPRS_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANPHOCN_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANKAT5_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANTBB2A_HUMANBioGRID, IntAct16169070 details
PTPRS_HUMANUBR1_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANCHD3_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANFEZ1_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANPROF2_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANUT14A_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANSETB1_HUMANBioGRID, HPRD, IntAct16169070 details
PTPRS_HUMANRAB35_HUMANHPRD, IntAct16169070 details
PTPRS_HUMANPTPRN_HUMANBioGRID, HPRD, IntAct16273344 details
PTPRS_HUMANTF3C3_HUMANIntAct32814053 details
PTPRS_HUMANLIPA1_HUMANBioGRID, HPRD27880917 8524829 9624153 details
PTPRS_HUMANPTPRD_HUMANBioGRID, HPRD22357843 28675297 9566880 details
PTPRS_HUMANLIPA2_HUMANBioGRID, HPRD9624153 details
PTPRS_HUMANLIPA3_HUMANBioGRID, HPRD9624153 details
PTPRS_HUMANGPC4_HUMANBioGRID25624497 details
PTPRS_HUMANGPC3_HUMANBioGRID25624497 details
PTPRS_HUMANGPC2_HUMANBioGRID25624497 details
PTPRS_HUMANGPC6_HUMANBioGRID25624497 details
PTPRS_HUMANSLIK1_HUMANBioGRID25394468 details
PTPRS_HUMANSUMO2_HUMANIntAct16169070 details
PTPRS_HUMANNTRK3_HUMANBioGRID, IntAct25624497 28514442 details
PTPRS_HUMANIL1AP_HUMANBioGRID22357843 details
PTPRS_HUMANNDKB_HUMANBioGRID26896769 details
PTPRS_HUMANPKD1_HUMANBioGRID21126580 details
PTPRS_HUMANCADH1_HUMANBioGRID21126580 details
PTPRS_HUMANLRRT4_HUMANBioGRID25624497 details
PTPRS_HUMANPTPRA_HUMANHPRD10777529 details
PTPRS_HUMANEGFR_HUMANHPRD10435588 details
PTPRS_HUMANPTPRE_HUMANHPRD12376545 details
PTPRS_HUMANPTPRM_HUMANHPRD12376545 details