Entity Details

Primary name KCC2D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13557
EntryNameKCC2D_HUMAN
FullNameCalcium/calmodulin-dependent protein kinase type II subunit delta
TaxID9606
Evidenceevidence at protein level
Length499
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCAMK2D

GO terms

Show/Hide Table
GOName
GO:0001558 regulation of cell growth
GO:0002026 regulation of the force of heart contraction
GO:0003254 regulation of membrane depolarization
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0008016 regulation of heart contraction
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010649 regulation of cell communication by electrical coupling
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019871 sodium channel inhibitor activity
GO:0030666 endocytic vesicle membrane
GO:0031432 titin binding
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0033017 sarcoplasmic reticulum membrane
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0044325 transmembrane transporter binding
GO:0046777 protein autophosphorylation
GO:0055119 relaxation of cardiac muscle
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060341 regulation of cellular localization
GO:0071277 cellular response to calcium ion
GO:0086003 cardiac muscle cell contraction
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098901 regulation of cardiac muscle cell action potential
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1901725 regulation of histone deacetylase activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901897 regulation of relaxation of cardiac muscle
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:2000650 negative regulation of sodium ion transmembrane transporter activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Sarcoplasmic reticulum membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR032710 NTF2-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB07853 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrileDrugbanksmall molecule
DB08039 (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
KCC2D_HUMANBANP_HUMANBioGRID, IntAct25416956 31515488 details
KCC2D_HUMANKCC2A_HUMANBioGRID, DIP, IntAct17353931 20668654 25852190 28514442 29426014 31980649 32296183 details
KCC2D_HUMANF171B_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANSPA24_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
KCC2D_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
KCC2D_HUMANERCC8_HUMANBioGRID26871637 details
KCC2D_HUMANIF4B_HUMANMINT18486612 details
KCC2D_HUMANKCC2D_HUMANBioGRID, DIP, HPRD, IntAct17192257 18082144 20668654 25416956 31515488 details
KCC2D_HUMANTNPO3_HUMANBioGRID, IntAct32296183 details
KCC2D_HUMANHDAC4_HUMANBioGRID16767219 17179159 27684187 31040226 details
KCC2D_HUMANHNMT_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANRS4X_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANWASF3_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANINGR2_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANTNPO2_HUMANBioGRID, IntAct25416956 31515488 details
KCC2D_HUMANKCC2B_HUMANBioGRID, DIP, HPRD, IntAct16185778 20668654 28514442 29426014 32296183 details
KCC2D_HUMANSTIP1_HUMANMINT18486612 details
KCC2D_HUMANDNAL4_HUMANBioGRID, IntAct25416956 31515488 details
KCC2D_HUMANEPHAA_HUMANBioGRID, IntAct25416956 details
KCC2D_HUMANTTC5_HUMANBioGRID, IntAct25416956 31515488 32296183 details
KCC2D_HUMANKCC2G_HUMANBioGRID, DIP, IntAct20668654 28514442 29426014 32296183 details
KCC2D_HUMANFKB1B_HUMANBioGRID, IntAct25416956 details
KCC2D_HUMANFND3B_HUMANBioGRID, IntAct25416956 29426014 details
KCC2D_HUMANFXR2_HUMANBioGRID, IntAct25416956 29395067 details
KCC2D_HUMANRM11_HUMANBioGRID, IntAct25416956 31515488 details
KCC2D_HUMANSNF5_HUMANBioGRID27229929 details
KCC2D_HUMANCD5_HUMANHPRD9692886 details
KCC2D_HUMANCALM2_HUMANDIP20668654 details
KCC2D_HUMANAR2BP_HUMANBioGRID, IntAct21988832 details
KCC2D_HUMANMOAP1_HUMANBioGRID, IntAct25416956 details
KCC2D_HUMANUBC9_HUMANBioGRID32296183 details
KCC2D_HUMANSCN5A_HUMANbhf-ucl22514276 details
KCC2D_HUMANCREM_HUMANHPRD8404858 details
KCC2D_HUMANDBNL_HUMANBioGRID, IntAct29426014 details
KCC2D_HUMANRS18_HUMANBioGRID, HPRD12145273 details
KCC2D_HUMANSTAT1_HUMANHPRD11972023 details
KCC2D_HUMANNMDE2_HUMANHPRD16120608 16436603 details
KCC2D_HUMANVIME_HUMANHPRD10852918 15345747 details
KCC2D_HUMANNEMO_HUMANIntAct14743216 details
KCC2D_HUMANRYR2_HUMANDIP20479242 details
KCC2D_HUMANAKT1_HUMANBioGRID24462114 details
KCC2D_HUMANHS90B_HUMANIntAct22939624 details
KCC2D_HUMANZN363_HUMANBioGRID, IntAct27519799 details
KCC2D_HUMANACTN2_HUMANHPRD16120608 details