Entity Details

Primary name ITPR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14573
EntryNameITPR3_HUMAN
FullNameInositol 1,4,5-trisphosphate receptor type 3
TaxID9606
Evidenceevidence at protein level
Length2671
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesITPR3

GO terms

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GOName
GO:0000822 inositol hexakisphosphate binding
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005509 calcium ion binding
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0015278 calcium-release channel activity
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030168 platelet activation
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031095 platelet dense tubular network membrane
GO:0035091 phosphatidylinositol binding
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043235 receptor complex
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0045177 apical part of cell
GO:0050796 regulation of insulin secretion
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051592 response to calcium ion
GO:0060291 long-term synaptic potentiation
GO:0060402 calcium ion transport into cytosol
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000493 Inositol 1,4,5-trisphosphate receptorFamilyFamily
IPR000699 RIH domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016093 MIR motifDomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
ITPR3_HUMANTRPC3_HUMANBioGRID, HPRD, IntAct10611319 11290752 11524429 15623527 details
ITPR3_HUMANTRPC6_HUMANBioGRID, HPRD, IntAct10611319 11290752 details
ITPR3_HUMANPP1A_HUMANUniProt19389623 details
ITPR3_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
ITPR3_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
ITPR3_HUMANBAP1_HUMANBioGRID, DIP28614305 details
ITPR3_HUMANTRPC1_HUMANBioGRID, HPRD10980191 11290752 19052258 details
ITPR3_HUMANTRPC4_HUMANBioGRID, HPRD11163362 11290752 details
ITPR3_HUMANTRPC5_HUMANBioGRID, HPRD11290752 details
ITPR3_HUMANTRPC7_HUMANBioGRID11290752 details
ITPR3_HUMANAKT1_HUMANBioGRID18250332 details
ITPR3_HUMANFBXL2_HUMANBioGRID28614300 32938669 details
ITPR3_HUMANBECN1_HUMANBioGRID22082873 details
ITPR3_HUMANB2L10_HUMANUniProt27995898 details
ITPR3_HUMANSGMR1_HUMANBioGRID, HPRD11149946 details
ITPR3_HUMANITPR1_HUMANBioGRID, HPRD7559486 details
ITPR3_HUMANCAV1_HUMANBioGRID19052258 details
ITPR3_HUMANTERA_HUMANBioGRID28614300 details
ITPR3_HUMANPTEN_HUMANBioGRID28614300 details
ITPR3_HUMANRN213_HUMANBioGRID28276505 details
ITPR3_HUMANBCL2_HUMANBioGRID15613488 details
ITPR3_HUMANST7_HUMANBioGRID29395067 details
ITPR3_HUMANPARK7_HUMANBioGRID31767755 details
ITPR3_HUMANGRP75_HUMANBioGRID31767755 details
ITPR3_HUMANVDAC1_HUMANBioGRID31767755 details
ITPR3_HUMANANK1_HUMANHPRD15051494 8385102 details
ITPR3_HUMANTRPM2_HUMANHPRD11290752 details
ITPR3_HUMANCABP1_HUMANHPRD12032348 14685260 details