Entity Details

Primary name IHH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14623
EntryNameIHH_HUMAN
FullNameIndian hedgehog protein
TaxID9606
Evidenceevidence at protein level
Length411
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesIHH

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003382 epithelial cell morphogenesis
GO:0003406 retinal pigment epithelium development
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0005113 patched binding
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006029 proteoglycan metabolic process
GO:0007224 smoothened signaling pathway
GO:0007267 cell-cell signaling
GO:0008233 peptidase activity
GO:0009612 response to mechanical stimulus
GO:0009880 embryonic pattern specification
GO:0010468 regulation of gene expression
GO:0016539 intein-mediated protein splicing
GO:0016540 protein autoprocessing
GO:0030704 vitelline membrane formation
GO:0031012 extracellular matrix
GO:0031016 pancreas development
GO:0032355 response to estradiol
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0035264 multicellular organism growth
GO:0035988 chondrocyte proliferation
GO:0040008 regulation of growth
GO:0042733 embryonic digit morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0045453 bone resorption
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046639 negative regulation of alpha-beta T cell differentiation
GO:0048074 negative regulation of eye pigmentation
GO:0048469 cell maturation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048666 neuron development
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051216 cartilage development
GO:0060135 maternal process involved in female pregnancy
GO:0060220 camera-type eye photoreceptor cell fate commitment
GO:0060323 head morphogenesis
GO:0061053 somite development
GO:0072498 embryonic skeletal joint development
GO:0090136 epithelial cell-cell adhesion
GO:0097421 liver regeneration

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000320 Hedgehog, N-terminal signalling domainDomainDomain
IPR001657 Hedgehog proteinFamilyFamily
IPR001767 Hedgehog protein, Hint domainDomainDomain
IPR003586 Hint domain C-terminalDomainDomain
IPR003587 Hint domain N-terminalDomainDomain
IPR006141 Intein N-terminal splicing regionPTMPTM
IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamilyFamilyHomologous superfamily
IPR033385 Indian hedgehog proteinFamilyFamily
IPR036844 Hint domain superfamilyFamilyHomologous superfamily

Diseases

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