Entity Details

Primary name MELK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14680
EntryNameMELK_HUMAN
FullNameMaternal embryonic leucine zipper kinase
TaxID9606
Evidenceevidence at protein level
Length651
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesMELK

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0004674 protein serine/threonine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008283 cell population proliferation
GO:0008289 lipid binding
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0016020 membrane
GO:0030097 hemopoiesis
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0061351 neural precursor cell proliferation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001772 Kinase associated domain 1 (KA1)DomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR034673 Maternal embryonic leucine zipper kinase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
MELK_HUMANB2L14_HUMANIntAct17280616 details
MELK_HUMANMPIP2_HUMANBioGRID, IntAct12400006 27173435 unassigned1312 details
MELK_HUMANZN622_HUMANBioGRID, HPRD11802789 details
MELK_HUMANLMNB1_HUMANBioGRID, HPRD16216881 details
MELK_HUMANMBP_HUMANBioGRID, HPRD16216881 details
MELK_HUMANMELK_HUMANBioGRID16216881 details
MELK_HUMANTAU_HUMANBioGRID21985311 details
MELK_HUMANEZH2_HUMANBioGRID31434700 details
MELK_HUMANSTK16_HUMANIntAct17353931 details
MELK_HUMANCDC5L_HUMANBioGRID, HPRD, MINT16216881 20467437 details
MELK_HUMANDCLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSI1L1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANGGYF1_HUMANIntActunassigned1312 details
MELK_HUMANHDAC4_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANCDK16_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANMAST3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANDEN4C_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANZN638_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANAN34A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSIN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANRAB3I_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANAGAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANPPM1H_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANUBP21_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANLIMA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANFA53C_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANRTKN_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSYDE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANF110B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANSRS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANMAGI1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANTESK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANF110A_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANCING_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MELK_HUMANPP1R8_HUMANHPRD16216881 details
MELK_HUMANSF3B1_HUMANHPRD16216881 details
MELK_HUMANH15_HUMANHPRD16216881 details
MELK_HUMANIF2A_HUMANHPRD16216881 details