Entity Details

Primary name GNMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14749
EntryNameGNMT_HUMAN
FullNameGlycine N-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length295
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesGNMT

GO terms

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GOName
GO:0005542 folic acid binding
GO:0005829 cytosol
GO:0005977 glycogen metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006464 cellular protein modification process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0016594 glycine binding
GO:0017174 glycine N-methyltransferase activity
GO:0019752 carboxylic acid metabolic process
GO:0032259 methylation
GO:0042802 identical protein binding
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046500 S-adenosylmethionine metabolic process
GO:0051289 protein homotetramerization
GO:1901052 sarcosine metabolic process
GO:1904047 S-adenosyl-L-methionine binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR014369 Glycine/Sarcosine N-methyltransferaseFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR041698 Methyltransferase domain 25DomainDomain

Diseases

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Disease IDSourceNameDescription
606664 OMIMGlycine N-methyltransferase deficiency (GNMT deficiency)The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00118 AdemetionineDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB01752 S-adenosyl-L-homocysteineDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
GNMT_HUMANARRC_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
GNMT_HUMANPKHF2_HUMANBioGRID, HPRD, IntAct16189514 details
GNMT_HUMANNIF3L_HUMANBioGRID, HPRD, IntAct16189514 details
GNMT_HUMANARRB1_HUMANBioGRID, HPRD, IntAct16189514 21988832 26871637 31515488 32296183 details
GNMT_HUMANNUD18_HUMANBioGRID, HPRD, IntAct16189514 details
GNMT_HUMANGNMT_HUMANBioGRID, HPRD, IntAct12697024 16189514 25416956 25502805 26871637 31515488 details
GNMT_HUMANHDAC7_HUMANBioGRID, MINT21516116 details
GNMT_HUMANRSSA_HUMANBioGRID, IntAct21988832 details
GNMT_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
GNMT_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
GNMT_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
GNMT_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
GNMT_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
GNMT_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
GNMT_HUMANCC153_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANHPRT_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANFRG1_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANU520_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANCTNS_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANCOX7B_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANGBRT_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANGAG2B_HUMANIntAct32296183 details
GNMT_HUMANS5A2_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANZN337_HUMANBioGRID, IntAct32296183 details
GNMT_HUMANSDCB1_HUMANBioGRID25416956 details
GNMT_HUMANATL4_HUMANBioGRID25416956 details
GNMT_HUMANKRA42_HUMANBioGRID25416956 details
GNMT_HUMANKR103_HUMANBioGRID25416956 details
GNMT_HUMANNT2NC_HUMANBioGRID25416956 details
GNMT_HUMANNT2NA_HUMANBioGRID25416956 details
GNMT_HUMANPREX2_HUMANBioGRID28205209 30796242 details
GNMT_HUMANGAG2A_HUMANBioGRID32296183 details
GNMT_HUMANHUWE1_HUMANBioGRID28205209 details
GNMT_HUMANKAPCA_HUMANHPRD12697024 2722853 details