Entity Details

Primary name NUMA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14980
EntryNameNUMA1_HUMAN
FullNameNuclear mitotic apparatus protein 1
TaxID9606
Evidenceevidence at protein level
Length2115
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesNUMA1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000139 Golgi membrane
GO:0000922 spindle pole
GO:0001578 microtubule bundle formation
GO:0005198 structural molecule activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005938 cell cortex
GO:0006997 nucleus organization
GO:0007059 chromosome segregation
GO:0008017 microtubule binding
GO:0008022 protein C-terminus binding
GO:0015631 tubulin binding
GO:0016328 lateral plasma membrane
GO:0016363 nuclear matrix
GO:0019897 extrinsic component of plasma membrane
GO:0019904 protein domain specific binding
GO:0030425 dendrite
GO:0030513 positive regulation of BMP signaling pathway
GO:0030953 astral microtubule organization
GO:0031116 positive regulation of microtubule polymerization
GO:0031616 spindle pole centrosome
GO:0032388 positive regulation of intracellular transport
GO:0032991 protein-containing complex
GO:0035091 phosphatidylinositol binding
GO:0035371 microtubule plus-end
GO:0036449 microtubule minus-end
GO:0043025 neuronal cell body
GO:0044877 protein-containing complex binding
GO:0045618 positive regulation of keratinocyte differentiation
GO:0051010 microtubule plus-end binding
GO:0051011 microtubule minus-end binding
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051798 positive regulation of hair follicle development
GO:0051984 positive regulation of chromosome segregation
GO:0055028 cortical microtubule
GO:0055048 anastral spindle assembly
GO:0060236 regulation of mitotic spindle organization
GO:0061673 mitotic spindle astral microtubule
GO:0070062 extracellular exosome
GO:0070840 dynein complex binding
GO:0072686 mitotic spindle
GO:0090235 regulation of metaphase plate congression
GO:0097427 microtubule bundle
GO:0097431 mitotic spindle pole
GO:0097575 lateral cell cortex
GO:0097718 disordered domain specific binding
GO:0099738 cell cortex region
GO:1902365 positive regulation of protein localization to spindle pole body
GO:1902846 positive regulation of mitotic spindle elongation
GO:1904778 positive regulation of protein localization to cell cortex
GO:1905720 cytoplasmic microtubule bundle
GO:1905820 positive regulation of chromosome separation
GO:1905832 positive regulation of spindle assembly
GO:1990023 mitotic spindle midzone

Subcellular Location

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Subcellular Location
Cell membrane
Chromosome
Cytoplasm
Lateral cell membrane
Nucleus
Nucleus matrix

Domains

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DomainNameCategoryType
IPR026650 Nuclear mitotic apparatus protein 1FamilyFamily

Diseases

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Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
NUMA1_HUMANGPSM2_HUMANBioGRID, HPRD, UniProt11781568 15537540 details
NUMA1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
NUMA1_HUMANTNKS2_HUMANIntAct22153077 details
NUMA1_HUMANCCD57_HUMANBioGRID, IntAct23718855 25416956 details
NUMA1_HUMANBRAP_HUMANBioGRID, IntAct23707952 25820252 details
NUMA1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
NUMA1_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
NUMA1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 34079125 details
NUMA1_HUMANRAE1L_HUMANBioGRID, DIP17172455 details
NUMA1_HUMANEPB41_HUMANBioGRID, HPRD10189366 details
NUMA1_HUMANE41L1_HUMANBioGRID, HPRD10594058 details
NUMA1_HUMANYETS4_HUMANBioGRID, HPRD10913114 11521196 details
NUMA1_HUMANTNKS1_HUMANBioGRID, HPRD12080061 details
NUMA1_HUMANE41L2_HUMANBioGRID, HPRD12239178 details
NUMA1_HUMANPIM1_HUMANBioGRID, HPRD12111331 details
NUMA1_HUMANEMIL1_HUMANBioGRID17609108 details
NUMA1_HUMAN1433T_HUMANBioGRID15161933 details
NUMA1_HUMANERG_HUMANBioGRID24591637 details
NUMA1_HUMANGMCL1_HUMANBioGRID25416956 details
NUMA1_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
NUMA1_HUMANABRX2_HUMANBioGRID26195665 details
NUMA1_HUMANBRCC3_HUMANBioGRID26195665 details
NUMA1_HUMANGNAI1_HUMANHPRD, UniProt15537540 details
NUMA1_HUMAN1433Z_HUMANMINT15161933 details
NUMA1_HUMANDCTN1_HUMANMINT23921553 details
NUMA1_HUMANGPTC1_HUMANIntAct30021884 details
NUMA1_HUMANSMRCD_HUMANBioGRID, IntAct21549307 30021884 details
NUMA1_HUMANK2C4_HUMANIntAct30021884 details
NUMA1_HUMAND42E2_HUMANIntAct30021884 details
NUMA1_HUMANEXOC1_HUMANIntAct31413325 details
NUMA1_HUMANDISC1_HUMANIntAct31413325 details
NUMA1_HUMANMIPT3_HUMANIntAct31413325 details
NUMA1_HUMANACTZ_HUMANBioGRID, HPRD10504299 details
NUMA1_HUMANSMC1A_HUMANBioGRID, HPRD11590136 details
NUMA1_HUMANSMC3_HUMANBioGRID11590136 details
NUMA1_HUMANNCOA6_HUMANBioGRID, HPRD12519782 details
NUMA1_HUMANNPM_HUMANBioGRID14968112 details
NUMA1_HUMANBAF_HUMANBioGRID19759913 details
NUMA1_HUMANHDAC5_HUMANBioGRID21081666 details
NUMA1_HUMANNUP98_HUMANBioGRID17172455 details
NUMA1_HUMANDYL1_HUMANBioGRID17172455 details
NUMA1_HUMANHS90A_HUMANBioGRID16263121 details
NUMA1_HUMANDVL1_HUMANBioGRID24469800 details
NUMA1_HUMANDVL2_HUMANBioGRID24469800 details
NUMA1_HUMANDVL3_HUMANBioGRID24469800 details
NUMA1_HUMANABCE1_HUMANBioGRID25659154 details
NUMA1_HUMANDYHC1_HUMANBioGRID26195665 details
NUMA1_HUMANIMB1_HUMANBioGRID26195665 details
NUMA1_HUMANU2AF2_HUMANBioGRID26641092 details
NUMA1_HUMANTXNIP_HUMANBioGRID27437069 details
NUMA1_HUMANRAD21_HUMANHPRD11590136 details