Entity Details

Primary name APOE
Entity type gene
Source Source Link

Details

PrimaryID348
RefseqGeneNG_007084
SymbolAPOE
Nameapolipoprotein E
Chromosome19
Location19q13.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-01-15
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsAPOE_HUMAN

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007271 synaptic transmission, cholinergic
GO:0007616 long-term memory
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008289 lipid binding
GO:0010467 gene expression
GO:0010544 negative regulation of platelet activation
GO:0010596 negative regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010873 positive regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0010877 lipid transport involved in lipid storage
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0015909 long-chain fatty acid transport
GO:0016020 membrane
GO:0016209 antioxidant activity
GO:0017038 protein import
GO:0019068 virion assembly
GO:0019934 cGMP-mediated signaling
GO:0030195 negative regulation of blood coagulation
GO:0030425 dendrite
GO:0030516 regulation of axon extension
GO:0030522 intracellular receptor signaling pathway
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0031175 neuron projection development
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034380 high-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0035641 locomotory exploration behavior
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042982 amyloid precursor protein metabolic process
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043254 regulation of protein-containing complex assembly
GO:0043395 heparan sulfate proteoglycan binding
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043687 post-translational protein modification
GO:0043691 reverse cholesterol transport
GO:0044267 cellular protein metabolic process
GO:0044794 positive regulation by host of viral process
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045807 positive regulation of endocytosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046907 intracellular transport
GO:0046911 metal chelating activity
GO:0046983 protein dimerization activity
GO:0048156 tau protein binding
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048844 artery morphogenesis
GO:0050709 negative regulation of protein secretion
GO:0050728 negative regulation of inflammatory response
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051246 regulation of protein metabolic process
GO:0051651 maintenance of location in cell
GO:0055089 fatty acid homeostasis
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060999 positive regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061771 response to caloric restriction
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0070328 triglyceride homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071682 endocytic vesicle lumen
GO:0071813 lipoprotein particle binding
GO:0071830 triglyceride-rich lipoprotein particle clearance
GO:0071831 intermediate-density lipoprotein particle clearance
GO:0072562 blood microparticle
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090181 regulation of cholesterol metabolic process
GO:0090209 negative regulation of triglyceride metabolic process
GO:0090370 negative regulation of cholesterol efflux
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0098978 glutamatergic synapse
GO:0120020 cholesterol transfer activity
GO:1900221 regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901627 negative regulation of postsynaptic membrane organization
GO:1901631 positive regulation of presynaptic membrane organization
GO:1902004 positive regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902947 regulation of tau-protein kinase activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902952 positive regulation of dendritic spine maintenance
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1902999 negative regulation of phospholipid efflux
GO:1903001 negative regulation of lipid transport across blood-brain barrier
GO:1903002 positive regulation of lipid transport across blood-brain barrier
GO:1903561 extracellular vesicle
GO:1905855 positive regulation of heparan sulfate binding
GO:1905860 positive regulation of heparan sulfate proteoglycan binding
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus
GO:1905906 regulation of amyloid fibril formation
GO:1905907 negative regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1990777 lipoprotein particle
GO:2000822 regulation of behavioral fear response

Diseases

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Interactions

183 interactions

InteractorPartnerSourcesPublicationsLink
APOEHPMINT19758344 details
APOEPDCD4BioGRID, IntAct21163940 details
APOECDC37BioGRID, IntAct21163940 details
APOEECSITBioGRID, IntAct21163940 details
APOEST13BioGRID, IntAct21163940 details
APOEA2MBioGRID, HPRD, IntAct21163940 9831625 details
APOEGCDHBioGRID, IntAct21163940 details
APOECYP2C8BioGRID, IntAct21163940 details
APOELOXL4BioGRID, IntAct21163940 details
APOEIFIT3BioGRID, IntAct21163940 details
APOEMAST1BioGRID, IntAct21163940 details
APOEPSEN1BioGRID, IntAct21163940 details
APOERNF32BioGRID, IntAct21163940 details
APOETMCC2IntAct21593558 details
APOEARFGAP1BioGRID, IntAct21988832 details
APOELRP8bhf-ucl, BioGRID, HPRD, IntAct12167620 12950167 32814053 8626535 details
APOELDLRHPRD, MINT, UniProt12036962 20030366 24447298 details
APOESORL1bhf-ucl, BioGRID11294867 17326667 details
APOEAPOEbhf-ucl, BioGRID, HPRD, UniProt15182176 21163940 7566652 8245722 9147408 details
APOEVLDLRDIP, HPRD12167620 19116273 details
APOEMAPTBioGRID, HPRD, IntAct, UniProt26402096 32814053 7566652 8620924 9147408 9512010 details
APOELRP1BioGRID, HPRD, UniProt11421580 15182176 20030366 2779654 details
APOETREM2BioGRID, UniProt27477018 30341064 details
APOECFHIntAct26468283 details
APOESNCABioGRID, IntAct26921451 28887769 31270237 details
APOELGALS1IntAct32814053 details
APOECNTFHPRD, IntAct32814053 9236223 details
APOESCARB1HPRD, IntAct12138091 32814053 details
APOEAPLP2IntAct32814053 details
APOEZNF24IntAct32814053 details
APOETNFAIP1IntAct32814053 details
APOEMT2AIntAct32814053 details
APOEMAP2IntAct32814053 details
APOEFOXD4L6IntAct32814053 details
APOEC20orf141IntAct32814053 details
APOESPATA2LIntAct32814053 details
APOELDHAL6BIntAct32814053 details
APOEC11orf49IntAct32814053 details
APOEDCLRE1BIntAct32814053 details
APOEUTP6IntAct32814053 details
APOERNF111IntAct32814053 details
APOEAK3IntAct32814053 details
APOEATP6V0A4IntAct32814053 details
APOEH2APIntAct32814053 details
APOETTC33IntAct32814053 details
APOEMSRB2IntAct32814053 details
APOERASSF1IntAct32814053 details
APOEEMILIN1IntAct32814053 details
APOERBM5IntAct32814053 details
APOEUBA3IntAct32814053 details
APOELRP2BioGRID, HPRD11421580 7768901 details
APOENEFMBioGRID, HPRD8620924 details
APOECSNK2A1BioGRID15882073 details
APOETIMM29BioGRID21163940 details
APOECYP2C18BioGRID21163940 details
APOEELAVL1BioGRID21163940 details
APOEFARSABioGRID21163940 details
APOEFBXL12BioGRID21163940 details
APOEIFIT5BioGRID21163940 details
APOELONP1BioGRID21163940 31536960 details
APOENOS3BioGRID21163940 details
APOEPRAM1BioGRID21163940 details
APOEPRDX2BioGRID21163940 details
APOERHEBBioGRID21163940 details
APOEACTG1BioGRID21163940 27684187 details
APOEANKHBioGRID21163940 details
APOEEPN2BioGRID21163940 details
APOEFOXG1BioGRID21163940 details
APOEFXYD7BioGRID21163940 details
APOEHTRA1BioGRID21163940 details
APOEIQSEC1BioGRID21163940 details
APOEMID1IP1BioGRID21163940 details
APOEPCMT1BioGRID21163940 details
APOEPLEKHA6BioGRID21163940 details
APOERPL4BioGRID21163940 27684187 details
APOETYRO3BioGRID21163940 details
APOEZNF558BioGRID21163940 details
APOELCATBioGRID15654758 details
APOEHSP90AA1BioGRID31273033 details
APOEALBBioGRID, HPRD, IntAct15174051 8063017 details
APOEAPOA2bhf-ucl8245722 details
APOEAPOC2bhf-ucl8245722 details
APOEAPPBioGRID, HPRD, MINT10559559 22528093 26213366 details
APOECLSTN3MINT26213366 details
APOETREM1UniProt30341064 details
APOETOPORSIntAct31413325 details
APOEPIAS3IntAct31413325 details
APOEHIPK1IntAct31413325 details
APOEZNF451IntAct31413325 details
APOEPLAG1IntAct31413325 details
APOESNRNP70IntAct31413325 details
APOEUBE2IIntAct31413325 details
APOEPIAS1IntAct31413325 details
APOEPIAS2IntAct31413325 details
APOECLCF1IntAct29507344 details
APOEPLTPBioGRID, HPRD12810820 details
APOEITGAMBioGRID23134465 details
APOECTSBHPRD12057992 details
APOEPRNPHPRD15146195 details
APOEVCAM1IntAct22623428 details
APOECD81BioGRID, IntAct30024968 32900848 details
APOEPLEKHA7IntAct28877994 details
APOEHLA-DPA1BioGRID, IntAct26186194 28514442 details
APOEMANSC1BioGRID, IntAct28514442 details
APOEIFNA8BioGRID, IntAct28514442 details
APOEMMRN1BioGRID, IntAct26186194 28514442 details
APOEMMP10BioGRID, IntAct28514442 details
APOEVDAC3BioGRID, IntAct28514442 details
APOEMMP3BioGRID, IntAct26186194 28514442 details
APOEC9BioGRID, IntAct28514442 details
APOECHRNA7UniProt28750690 details
APOECHRFAM7AUniProt28750690 details
APOEVDAC1BioGRID26186194 28514442 details
APOERPS14BioGRID27684187 details
APOERPS7BioGRID27684187 details
APOERPL8BioGRID27684187 details
APOETPM1BioGRID27684187 details
APOEYWHAZBioGRID27684187 details
APOECTNNB1BioGRID27684187 details
APOEPCBP1BioGRID27684187 details
APOECLTCBioGRID27684187 details
APOERPS26BioGRID27684187 details
APOERPL6BioGRID27684187 details
APOETPM3BioGRID27684187 details
APOEHSPA8BioGRID27684187 details
APOERPS28BioGRID27684187 details
APOERRBP1BioGRID27684187 details
APOESENP2BioGRID29969578 details
APOEAGRNBioGRID29872149 details
APOEUQCRC2BioGRID31536960 details
APOEATP5F1BBioGRID31536960 details
APOEUQCRC1BioGRID31536960 details
APOEAGPSBioGRID31536960 details
APOELRRC59BioGRID31536960 details
APOEPORBioGRID31536960 details
APOEPDHA1BioGRID31536960 details
APOEPHB2BioGRID31536960 details
APOEPDHBBioGRID31536960 details
APOEACTBBioGRID31536960 details
APOECANXBioGRID31536960 details
APOEP4HA1BioGRID31536960 details
APOEATP5F1ABioGRID31536960 details
APOEPHBBioGRID31536960 details
APOENNTBioGRID31536960 details
APOEHADHABioGRID31536960 details
APOENDUFS7BioGRID31536960 details
APOECYB5R3BioGRID31536960 details
APOEHMOX2BioGRID31536960 details
APOEHADHBBioGRID31536960 details
APOENDUFS1BioGRID31536960 details
APOEOGDHBioGRID31536960 details
APOENDUFS3BioGRID31536960 details
APOENDUFA8BioGRID31536960 details
APOECYB5R1BioGRID31536960 details
APOEEEF2BioGRID31536960 details
APOEVCPBioGRID31536960 details
APOESFXN1BioGRID31536960 details
APOENDUFS8BioGRID31536960 details
APOESLC25A24BioGRID31536960 details
APOENIPSNAP1BioGRID31536960 details
APOEPTGES2BioGRID31536960 details
APOEEMC8BioGRID31536960 details
APOEPRDX3BioGRID31536960 details
APOEATP5POBioGRID31536960 details
APOEUQCRHBioGRID31536960 details
APOELRPPRCBioGRID31536960 details
APOETUFMBioGRID31536960 details
APOENDUFV1BioGRID31536960 details
APOETPP1BioGRID31536960 details
APOEATP6V1ABioGRID31536960 details
APOEBCKDHABioGRID31536960 details
APOEEMC2BioGRID31536960 details
APOERCN2BioGRID31536960 details
APOEATP2A2BioGRID31536960 details
APOECYC1BioGRID31536960 details
APOEATP5F1CBioGRID31536960 details
APOERAB7ABioGRID31536960 details
APOESCCPDHBioGRID31536960 details
APOEHSPA5BioGRID31536960 details
APOELETM1BioGRID31536960 details
APOENDUFB8BioGRID31536960 details
APOETFRCBioGRID31536960 details
APOEATF4IntAct22028770 details