Entity Details

Primary name KDR
Entity type gene
Source Source Link

Details

PrimaryID3791
RefseqGeneNG_012004
SymbolKDR
Namekinase insert domain receptor
Chromosome4
Location4q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsVGFR2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003158 endothelium development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0010595 positive regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030054 cell junction
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0035162 embryonic hemopoiesis
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038085 vascular endothelial growth factor binding
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045446 endothelial cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050927 positive regulation of positive chemotaxis
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0051894 positive regulation of focal adhesion assembly
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061042 vascular wound healing
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0097443 sorting endosome
GO:1904881 cellular response to hydrogen sulfide
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001214 positive regulation of vasculogenesis

Diseases

Show/Hide Table

Interactions

102 interactions

InteractorPartnerSourcesPublicationsLink
KDRSHC1BioGRID, HPRD, MINT10319320 10749680 11950700 12214271 details
KDRVEGFAbhf-ucl, BioGRID, DIP, HPRD, IntAct, matrixdb, MINT12716911 1417831 16423422 16763549 16901919 17318185 18325345 19818105 20145116 20660291 21596751 22897854 23374253 23583373 25644401 28303365 30236477 31932617 8621427 details
KDRPTPRJMINT18936167 details
KDRSRCBioGRID, HPRD, Molecular Connections, UniProt10455194 12509223 16966330 18194650 18377662 18662404 19050761 22689825 details
KDRPTPN6BioGRID, HPRD, MINT, Molecular Connections12887919 16453023 18377662 28065597 28183800 9405464 details
KDRPLCG1BioGRID, HPRD, MINT12598525 9398617 details
KDRFBXW11BioGRID, MINT21900206 22711876 details
KDRAIMP2BioGRID, MINT21900206 details
KDRHSPG2matrixdb, MINT21596751 23374253 details
KDRPDCD6UniProt21893193 details
KDRKDRbhf-ucl, BioGRID, DIP, HPRD10102632 10368301 10579917 10749680 16007196 17293873 20080685 20190562 20660291 28303365 details
KDRGREM1bhf-ucl20660291 details
KDRLGALS1IntAct24529377 details
KDRVEGFCBioGRID, DIP, HPRD11332691 18593464 20145116 details
KDRPPM1ABioGRID, MINT28065597 details
KDRDUSP19BioGRID, MINT28065597 details
KDRILKAPBioGRID, MINT28065597 details
KDRPPM1BBioGRID, MINT28065597 details
KDRSTYXBioGRID, MINT28065597 details
KDRPTPRRBioGRID, MINT28065597 details
KDRPTPN11BioGRID, HPRD, MINT16339483 28065597 9405464 details
KDRPTPN12BioGRID, MINT28065597 details
KDRHTRA4IntAct30601675 details
KDRANOS1MINT31932617 details
KDRANXA5BioGRID, HPRD10329451 details
KDRSHC2BioGRID, HPRD10749680 12214271 9790910 details
KDRFLT1BioGRID, HPRD10865839 12796773 25387128 details
KDRVEGFDBioGRID, HPRD9435229 details
KDRGRB10BioGRID, HPRD11494124 details
KDRACP1BioGRID, HPRD10608891 details
KDRCOL18A1BioGRID, HPRD12029087 details
KDRCBLBioGRID, HPRD12649282 17372230 20011623 details
KDRBTRCBioGRID21402774 22711876 details
KDRCSNK1DBioGRID22711876 details
KDRIQGAP1BioGRID, HPRD15217908 19050761 details
KDRFBXO25BioGRID23940030 details
KDRSH2D2ABioGRID, HPRD10692392 15962004 22689825 details
KDRAPPBioGRID19818105 details
KDRMAPK1BioGRID20190562 details
KDRGABARAPBioGRID24686084 details
KDRSERPINF1BioGRID16901919 details
KDRCCDC88ABioGRID25187647 details
KDRPDCL3BioGRID23792958 details
KDRATRHPRD10749680 details
KDRCDH5BioGRID, HPRD, MINT, Molecular Connections10428027 11950700 18662404 25657827 details
KDRNRP1BioGRID, HPRD, IntAct, MINT11333271 11886873 11948691 16763549 17222790 19857463 26037503 details
KDRFLT4HPRD, IntAct, MINT15474514 16530705 20224550 21130043 details
KDRGRB2BioGRID, HPRD, MINT10319320 16966330 details
KDRNCK1BioGRID, HPRD, MINT12214271 16966330 9405464 details
KDRFYNHPRD, MINT16966330 7929439 details
KDRSHBBioGRID, HPRD, MINT15026417 details
KDRMETIntAct22789536 details
KDRCRKHPRD, IntAct15051508 23397142 details
KDRITGA2matrixdb21596751 details
KDREEA1IntAct23799140 details
KDRPDGFRBDIP18997771 details
KDRLRP8DIP30139844 details
KDRITGB1BioGRID, IntAct12114318 18931684 details
KDRPLXNA1BioGRID14977921 details
KDRRASA1BioGRID, HPRD10319320 details
KDRCUL1BioGRID22711876 details
KDREPN1BioGRID23187125 details
KDRMYO1CBioGRID23262137 details
KDRCAV1BioGRID, HPRD12529448 23262137 details
KDRTXNIPBioGRID23393387 details
KDRRAB5ABioGRID23393387 details
KDRITGB3BioGRID, HPRD10022831 25644401 details
KDRCSF2RBBioGRID, HPRD16007196 details
KDRDNM2BioGRID, HPRD16049137 details
KDRSCUBE2BioGRID27834687 details
KDRTNFRSF25BioGRID28183800 details
KDRITGA5BioGRID12114318 details
KDRUBCBioGRID23792958 details
KDRHSP90AA1BioGRID, HPRD12820653 15247219 details
KDRVCLBioGRID12820653 details
KDRPLXND1BioGRID26037503 details
KDRUSP14BioGRID32908134 details
KDRPLCG2HPRD9398617 details
KDRP2RY2HPRD15175347 details
KDRGNA11HPRD12670961 details
KDRSTAT1HPRD10961983 details
KDRGNAQHPRD12670961 details
KDRBMXHPRD14532277 details
KDRFRS2HPRD12154000 details
KDRYES1HPRD7929439 details
KDRTIMP3HPRD12652295 details
KDRCTNNB1HPRD12920240 details
KDRSYNGAP1HPRD9405464 details
KDRPKMIntAct24606918 details
KDRNAXDBioGRID, IntAct26496610 details
KDRYWHAGBioGRID, IntAct26496610 details
KDRTUT7BioGRID, IntAct26496610 details
KDRPALLDBioGRID, IntAct26496610 details
KDRGATCBioGRID, IntAct26496610 details
KDRRALGDSIntAct23175184 unassigned1271 details
KDRHSPD1BioGRID, IntAct30021884 details
KDRATP5F1ABioGRID, IntAct30021884 details
KDRANTXR1IntAct18931684 details
KDRNPM1BioGRID23402259 details
KDRZSCAN21BioGRID26496610 details
KDRNCOA4BioGRID26496610 details
KDRAAR2BioGRID26496610 details