Entity Details

Primary name KIT
Entity type gene
Source Source Link

Details

PrimaryID3815
RefseqGeneNG_007456
SymbolKIT
NameKIT proto-oncogene, receptor tyrosine kinase
Chromosome4
Location4q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1995-03-30
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsKIT_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001541 ovarian follicle development
GO:0001650 fibrillar center
GO:0001669 acrosomal vesicle
GO:0002020 protease binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002327 immature B cell differentiation
GO:0002551 mast cell chemotaxis
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006687 glycosphingolipid metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008360 regulation of cell shape
GO:0008542 visual learning
GO:0008584 male gonad development
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0019955 cytokine binding
GO:0030032 lamellipodium assembly
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030318 melanocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031274 positive regulation of pseudopodium assembly
GO:0031532 actin cytoskeleton reorganization
GO:0032765 positive regulation of mast cell cytokine production
GO:0033674 positive regulation of kinase activity
GO:0035019 somatic stem cell population maintenance
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0035701 hematopoietic stem cell migration
GO:0035855 megakaryocyte development
GO:0038093 Fc receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0038162 erythropoietin-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043069 negative regulation of programmed cell death
GO:0043235 receptor complex
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043586 tongue development
GO:0045747 positive regulation of Notch signaling pathway
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046686 response to cadmium ion
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048103 somatic stem cell division
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048565 digestive tract development
GO:0048863 stem cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060374 mast cell differentiation
GO:0070662 mast cell proliferation
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097324 melanocyte migration
GO:0097326 melanocyte adhesion
GO:0120072 positive regulation of pyloric antrum smooth muscle contraction
GO:1904251 regulation of bile acid metabolic process
GO:1904343 positive regulation of colon smooth muscle contraction
GO:1904349 positive regulation of small intestine smooth muscle contraction
GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation

Diseases

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Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
KITKITLGBioGRID, HPRD, IntAct1375232 1379243 17662946 7680037 details
KITPTPRJIntAct19167335 details
KITGRB2BioGRID, HPRD, IntAct, MINT10022833 10377264 12444928 17452978 17904548 24728074 7523381 7523859 8647802 8950973 details
KITCRKBioGRID, HPRD, IntAct, MINT12878163 24728074 9092574 9233773 details
KITPIK3R1BioGRID, HPRD, IntAct, MINT10022833 11071635 12878163 1382595 17452978 24728074 25241761 7509796 7537096 9233773 details
KITGRB7BioGRID, HPRD, IntAct, MINT10377264 12444928 24728074 details
KITPLCG1BioGRID, HPRD, IntAct, MINT11071635 14647465 24728074 25241761 7536744 7537096 details
KITPIK3R2BioGRID, HPRD, IntAct, MINT10022833 24728074 7537096 details
KITPTPN6BioGRID, HPRD, MINT12614164 7684496 9528781 details
KITSTAT1BioGRID, HPRD, IntAct25241761 9355737 details
KITPTPN11BioGRID, HPRD, IntAct12444928 24728074 7523381 9528781 details
KITPLCG2BioGRID, IntAct24728074 details
KITPIK3R3BioGRID, IntAct24728074 details
KITSOCS6BioGRID, HPRD, IntAct14707129 21030588 24728074 details
KITSH2D1BBioGRID, IntAct24728074 details
KITSH3BP2BioGRID, IntAct24728074 details
KITSH2D2ABioGRID, IntAct24728074 details
KITSH2B3BioGRID, HPRD, IntAct11805142 18588518 24728074 details
KITLCKBioGRID, HPRD, IntAct24728074 9788619 details
KITSH2D3CBioGRID, IntAct24728074 details
KITSRCBioGRID, HPRD, IntAct12444928 12878163 24728074 details
KITRASA1BioGRID, HPRD, IntAct11071635 24728074 details
KITZAP70BioGRID, IntAct24728074 details
KITYES1BioGRID, HPRD, IntAct11071635 24728074 details
KITFGRBioGRID, IntAct24728074 details
KITTNS2BioGRID, IntAct24728074 details
KITSHC1BioGRID, IntAct24728074 details
KITSHC2BioGRID, IntAct24728074 details
KITHSH2DBioGRID, IntAct24728074 details
KITHCKBioGRID, HPRD, IntAct11071635 24728074 details
KITABL2BioGRID, IntAct24728074 details
KITSOCS2BioGRID, IntAct24728074 details
KITTNS3BioGRID, IntAct24728074 details
KITSTAP1BioGRID, HPRD, IntAct10679268 24728074 details
KITSH2D1ABioGRID, IntAct24728074 details
KITLYNBioGRID, HPRD, IntAct11825908 24728074 9341198 details
KITNCK1BioGRID, IntAct24728074 details
KITBLNKBioGRID, IntAct24728074 details
KITNCK2BioGRID, IntAct24728074 details
KITBCAR3BioGRID, IntAct24728074 details
KITSHC3BioGRID, IntAct24728074 details
KITTXKBioGRID, IntAct24728074 details
KITSHC4BioGRID, IntAct24728074 details
KITBLKBioGRID, IntAct24728074 details
KITPTK6BioGRID, IntAct24728074 details
KITFESBioGRID, IntAct24728074 details
KITABL1BioGRID, HPRD, IntAct12374739 24728074 details
KITSOCS3BioGRID, IntAct24728074 details
KITSLA2BioGRID, IntAct24728074 details
KITGRAP2BioGRID, HPRD, IntAct24728074 9872323 details
KITSHBBioGRID, IntAct24728074 details
KITSYKBioGRID, IntAct24728074 details
KITSOCS5BioGRID, HPRD, IntAct14707129 24728074 details
KITTNS1BioGRID, IntAct24728074 details
KITVAV3BioGRID, IntAct24728074 details
KITTECBioGRID, HPRD, IntAct11071635 24728074 7526158 details
KITSTYXBioGRID, MINT28065597 details
KITILKAPBioGRID, MINT28065597 details
KITSOCS1BioGRID, HPRD10022833 29991678 details
KITCRKLBioGRID, HPRD11071635 9092574 details
KITINPP5DBioGRID, HPRD11071635 details
KITDOK1BioGRID, HPRD11825908 details
KITGRB10BioGRID, HPRD11809791 details
KITMATKBioGRID, HPRD7536744 9038210 details
KITMPDZBioGRID, HPRD11018522 details
KITGRAPBioGRID, HPRD8647802 details
KITIL7RBioGRID17554063 details
KITJAK3BioGRID17554063 details
KITSTAT5BBioGRID, HPRD10358045 17554063 details
KITPTPN20BioGRID28065597 details
KITKITBioGRID, HPRD10377264 1379243 9799234 9949175 details
KITCSF1RBioGRID9949175 details
KITBMPR2BioGRID16155937 details
KITPTPRUHPRD, MINT10397721 details
KITPTPN12MINT12614164 details
KITPIK3CGBioGRID, HPRD, IntAct25241761 7520444 details
KITBCRBioGRID, IntAct25241761 8757502 details
KITCSF2RABioGRID, HPRD, IntAct16760463 25241761 details
KITCD9BioGRID, HPRD12036870 details
KITCD63BioGRID12036870 details
KITCD81BioGRID, HPRD12036870 details
KITCLTCBioGRID, HPRD10477727 details
KITJAK2BioGRID, HPRD7527392 8611693 9355737 details
KITPTPROBioGRID, HPRD10397721 details
KITSH3KBP1BioGRID12177062 details
KITCBLBBioGRID, HPRD12177062 15315962 details
KITCBLBioGRID, HPRD15315962 25737303 8950973 details
KITPDGFRABioGRID17452978 details
KITHSP90B1BioGRID25737303 details
KITPIK3CABioGRID7691885 details
KITPLCE1BioGRID, HPRD12878163 details
KITACTA1BioGRID12878163 details
KITFYNBioGRID, HPRD12374739 14647465 9799234 details
KITKHDRBS1BioGRID14647465 details
KITPRKCAHPRD7539802 details
KITSPRED1HPRD12646235 details
KITSH2B2HPRD10872802 details
KITSPRED2HPRD12646235 14981116 details
KITCSF2RBHPRD15308671 details
KITPRKCBHPRD7693453 details
KITBTKHPRD15007095 details
KITSTAT5AHPRD10358045 details
KITCISHHPRD14707129 details
KITEPORHPRD11124255 details
KITPKMIntAct24606918 details
KITIRF3BioGRID, MINT25609649 details
KITPSMD14BioGRID30745168 details