Entity Details

Primary name MCL1
Entity type gene
Source Source Link

Details

PrimaryID4170
RefseqGeneNG_029146
SymbolMCL1
NameMCL1 apoptosis regulator, BCL2 family member
Chromosome1
Location1q21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-11-03
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsMCL1_HUMAN

GO terms

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GOName
GO:0001709 cell fate determination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0007275 multicellular organism development
GO:0008320 protein transmembrane transporter activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010507 negative regulation of autophagy
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019725 cellular homeostasis
GO:0034097 response to cytokine
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

102 interactions

InteractorPartnerSourcesPublicationsLink
MCL1HUWE1BioGRID, DIP, HPRD, MINT, Molecular Connections15989957 16213503 19148187 20007713 20023629 21298030 21507240 21613222 21730980 21907705 22552282 25147182 27517746 28193319 29799788 32378766 details
MCL1BCL2L11BioGRID, HPRD, I2D, IntAct, MINT, Molecular Connections10837489 15694340 15721256 15989957 16213503 16697956 17097560 17525735 19148187 19150432 19483105 19622586 20074640 20085765 20159608 20836993 21132008 21199865 21507240 21613222 22516262 23245996 26045051 26186194 26859456 27013495 28514442 9731710 details
MCL1BAK1BioGRID, DIP, HPRD, I2D, IntAct, MINT, Molecular Connections10579309 10837489 15077116 15637055 15901672 17097560 18040043 19148187 19483105 19968986 20023629 20836993 21132008 21613222 22516262 23680104 26004684 26045051 26186194 27818144 28514442 32296183 details
MCL1PMAIP1BioGRID, HPRD, I2D, IntAct, MINT15694340 15721256 15901672 16697956 19148187 20085765 21132008 21139584 21454712 21613222 22219388 22361683 23341456 26045051 27517746 29799788 32094511 32913203 details
MCL1BIDBioGRID, DIP, HPRD, IntAct15637055 15694340 16697956 19074266 21613222 details
MCL1BIKBioGRID, HPRD, IntAct15694340 16697956 21613222 details
MCL1BBC3BioGRID, HPRD, IntAct15694340 15721256 16007132 16697956 21613222 21730980 22516262 26186194 26431330 28202514 28514442 details
MCL1BAXBioGRID, DIP, HPRD, IntAct, MINT10837489 15077116 17525735 18981409 19148187 19968986 21199865 21458670 21566062 26186194 28514442 details
MCL1IER3IntAct15451437 details
MCL1MCL1BioGRID, HPRD, MINT10837489 19683529 details
MCL1TNKS2IntAct22153077 details
MCL1UHRF2BioGRID, UniProt21952639 details
MCL1HRKBioGRID, UniProt15031724 15694340 details
MCL1STX8BioGRID, IntAct32296183 details
MCL1KCNF1BioGRID, IntAct32296183 details
MCL1BMFBioGRID, HPRD, IntAct11546872 15694340 15721256 16697956 32296183 details
MCL1TRIM11BioGRID, IntAct26186194 28514442 32504673 details
MCL1USP9XBioGRID, DIP20023629 21566062 21907705 23097624 23171055 details
MCL1CHRM4BioGRID, MINT28298427 details
MCL1PCNABioGRID, HPRD, UniProt10978339 26030842 details
MCL1BADBioGRID, HPRD10579309 10837489 11483855 15694340 details
MCL1BOKBioGRID, HPRD10579309 9356461 details
MCL1CASP3BioGRID, HPRD15637055 details
MCL1VDAC1BioGRID, HPRD15637055 details
MCL1TNKSBioGRID, HPRD12475993 details
MCL1DAD1BioGRID, HPRD10965038 details
MCL1MAPK10BioGRID17670986 details
MCL1PIN1BioGRID17670986 details
MCL1BTRCBioGRID17387146 19150432 details
MCL1TP53BioGRID24491548 27818144 details
MCL1TPT1BioGRID, HPRD11598139 12149273 15870695 details
MCL1TRAF6BioGRID25340740 details
MCL1FBXW7BioGRID22608923 28202514 28522751 28619760 32081857 32276600 32352219 details
MCL1UBXN6BioGRID27913212 details
MCL1GSK3BBioGRID, HPRD16543145 17387146 details
MCL1GSK3ABioGRID, HPRD16543145 17387146 details
MCL1MAPK1BioGRID, HPRD15241487 17387146 details
MCL1FBXW11BioGRID17387146 details
MCL1USP13BioGRID29335437 details
MCL1EP300BioGRID20829524 details
MCL1HIF1ABioGRID20829524 details
MCL1APEX1BioGRID20829524 details
MCL1COX4I1MINT19683529 details
MCL1ACTBMINT19683529 details
MCL1GAPDHMINT19683529 details
MCL1BECN1BioGRID, MINT21139567 22219388 details
MCL1CAV1BioGRID, IntAct22277751 details
MCL1RTL10IntAct23055042 details
MCL1BCL2L1BioGRID, HPRD10837489 15077116 details
MCL1HSPA4BioGRID19148187 21298030 details
MCL1HSPA8BioGRID19148187 details
MCL1ATG12BioGRID22152474 details
MCL1BAG3BioGRID23341456 details
MCL1HSPA1ABioGRID23341456 details
MCL1BAG4BioGRID23341456 details
MCL1PRKNBioGRID24999239 details
MCL1PINK1BioGRID24999239 details
MCL1CUL1BioGRID28522751 28776569 details
MCL1SKP1BioGRID28522751 28776569 details
MCL1FBXO4BioGRID28776569 details
MCL1ERBB2BioGRID26921175 details
MCL1USP17L2BioGRID30718431 details
MCL1OTUD1BioGRID31467488 details
MCL1SQSTM1BioGRID32585451 details
MCL1ATPAF1MINT19968986 details
MCL1HSPD1MINT20627101 details
MCL1BCL2MINT21139567 details
MCL1C5AR2BioGRID, IntAct28514442 details
MCL1EDEM2BioGRID, IntAct28514442 details
MCL1RANBP6BioGRID, IntAct28514442 details
MCL1EDNRABioGRID, IntAct26186194 28514442 details
MCL1PRKAA1BioGRID, IntAct26186194 28514442 details
MCL1PRKAB1BioGRID, IntAct26186194 28514442 details
MCL1STARD9BioGRID, IntAct26186194 28514442 details
MCL1ASPRV1BioGRID, IntAct26186194 28514442 details
MCL1ECM1BioGRID, IntAct26186194 28514442 details
MCL1CPT2BioGRID, IntAct26186194 28514442 details
MCL1ARG1BioGRID, IntAct28514442 details
MCL1SERPINB7BioGRID, IntAct26186194 28514442 details
MCL1PRKAB2BioGRID, IntAct26186194 28514442 details
MCL1SEPTIN9BioGRID, IntAct30021884 details
MCL1ATG2AIntAct31412244 details
MCL1LYNBioGRID23503679 details
MCL1PRKAG1BioGRID26186194 details
MCL1FLGBioGRID26186194 details
MCL1DUSP22BioGRID27432908 details
MCL1EGLN3BioGRID26972000 details
MCL1HRASBioGRID30194290 details
MCL1NRASBioGRID30194290 details
MCL1KRASBioGRID30194290 details
MCL1BAG6BioGRID31536960 details
MCL1DBIBioGRID31536960 details
MCL1PEBP1BioGRID31536960 details
MCL1MLLT11BioGRID31536960 details
MCL1NSFL1CBioGRID31536960 details
MCL1TXLNGBioGRID31536960 details
MCL1RBM10BioGRID31536960 details
MCL1CITBioGRID31586073 details
MCL1AGO2BioGRID19167051 details
MCL1NXF1BioGRID22658674 details
MCL1UNKBioGRID25737280 details
MCL1DDX58BioGRID32513696 details