Entity Details

Primary name MME
Entity type gene
Source Source Link

Details

PrimaryID4311
RefseqGeneNG_051105
SymbolMME
Namemembrane metalloendopeptidase
Chromosome3
Location3q25.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsNEP_HUMAN

GO terms

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GOName
GO:0001786 phosphatidylserine binding
GO:0001822 kidney development
GO:0001890 placenta development
GO:0002003 angiotensin maturation
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0007568 aging
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019233 sensory perception of pain
GO:0030324 lung development
GO:0030424 axon
GO:0030425 dendrite
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle
GO:0042277 peptide binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043312 neutrophil degranulation
GO:0044306 neuron projection terminus
GO:0045121 membrane raft
GO:0045202 synapse
GO:0046449 creatinine metabolic process
GO:0050435 amyloid-beta metabolic process
GO:0050769 positive regulation of neurogenesis
GO:0061837 neuropeptide processing
GO:0070012 oligopeptidase activity
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0071492 cellular response to UV-A
GO:0071493 cellular response to UV-B
GO:0090399 replicative senescence
GO:0097242 amyloid-beta clearance
GO:0098793 presynapse
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901612 cardiolipin binding

Diseases

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Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
MMEFMR1IntAct32814053 details
MMEAPPIntAct32814053 details
MMECSNK2A1BioGRID20957047 8943850 details
MMELYNBioGRID, HPRD11104793 8943850 details
MMEAGTBioGRID15283675 details
MMENPPABioGRID, HPRD2531377 2972276 9232196 details
MMEPTENBioGRID14749127 20957047 details
MMEEZRBioGRID20957047 details
MMEHSPA1ABioGRID, IntAct17342744 details
MMEHSPA1BIntAct17342744 details
MMEHSPB1BioGRID, IntAct17342744 details
MMECD9MINT23289620 details
MMEHSPA4BioGRID17342744 details
MMEMMEBioGRID21515054 details
MMEPTK2BioGRID11104793 details
MMECSNK2BHPRD8943850 details
MMEGASTHPRD2736261 details
MMEPIK3R1HPRD12529960 details
MMESHC1HPRD9659899 details
MMEPIK3CBHPRD12529960 details
MMENPPCHPRD9232196 details
MMEEDN1HPRD2201681 details
MMEEDN2HPRD2201681 details
MMEADCYAP1HPRD9313778 details
MMEVIPHPRD9313778 details
MMEADMHPRD8687431 details
MMEACTBIntAct15047060 details
MMENDRG1BioGRID, HPRD, IntAct17220478 details
MMEINPP5DBioGRID, IntAct17342744 details
MMEZMPSTE24BioGRID, IntAct17342744 details
MMEFAM83FBioGRID, IntAct17342744 details
MMETUBB8BioGRID, IntAct17342744 details
MMENOLC1BioGRID, IntAct17342744 details
MMEH2AC13IntAct17342744 details
MMEH2AC15IntAct17342744 details
MMEH2AC16IntAct17342744 details
MMEH2AC17IntAct17342744 details
MMEH2AC11BioGRID, IntAct17342744 details
MMEIMPDH2BioGRID, IntAct17342744 details
MMEXRCC5BioGRID, IntAct17342744 details
MMEARL1BioGRID, IntAct17342744 details
MMERPL30BioGRID, IntAct17342744 details
MMEATP5MFBioGRID, IntAct17342744 details
MMERPS23BioGRID, IntAct17342744 details
MMEMTHFD1BioGRID, IntAct17342744 details
MMEKBTBD3BioGRID, IntAct17342744 details
MMENDUFB4BioGRID, IntAct17342744 details
MMERBM39BioGRID, IntAct17342744 details
MMENDUFA10BioGRID, IntAct17342744 details
MMETM9SF1BioGRID, IntAct17342744 details
MMEHSPA8BioGRID, IntAct17342744 details
MMEFLOT2BioGRID, IntAct17342744 details
MMEFOLH1BioGRID, IntAct17342744 details
MMEFECHBioGRID, IntAct17342744 details
MMESLC16A1BioGRID, IntAct17342744 details
MMETNPO1BioGRID, IntAct17342744 details
MMEVDAC2BioGRID, IntAct17342744 details
MMEMETTL7ABioGRID, IntAct17342744 details
MMEIRAG1BioGRID, IntAct17342744 details
MMEEEF1A1BioGRID, IntAct17342744 details
MMECLEC4MBioGRID, IntAct17342744 details
MMEOPA1BioGRID, IntAct17342744 details
MMELONP1BioGRID, IntAct17342744 details
MMEALDH3A2BioGRID, IntAct17342744 details
MMEMYH9BioGRID, IntAct17342744 details
MMEARMC10BioGRID, IntAct17342744 details
MMEPCNABioGRID, IntAct17342744 details
MMEPDIA5BioGRID, IntAct17342744 details
MMEMTDHBioGRID, IntAct17342744 details
MMEIRAK2BioGRID, IntAct17342744 details
MMECDK5RAP3BioGRID, IntAct17342744 details
MMEATP12ABioGRID, IntAct17342744 details
MMEUBAC2BioGRID, IntAct17342744 details
MMENDUFA9BioGRID, IntAct17342744 details
MMENNTBioGRID, IntAct17342744 details
MMEKRT10BioGRID, IntAct17342744 details
MMENUCKS1BioGRID, IntAct17342744 details
MMELMNABioGRID, IntAct17342744 details
MMERAP2BBioGRID, IntAct17342744 details
MMEFAHD1BioGRID, IntAct17342744 details
MMESSR4BioGRID, IntAct17342744 details
MMELAMTOR1BioGRID, IntAct17342744 details
MMEDNAJB12BioGRID, IntAct17342744 details
MMESRSF11BioGRID, IntAct17342744 details
MMEMRPS25BioGRID, IntAct17342744 details
MMEFAM234ABioGRID, IntAct17342744 details
MMEFAAHBioGRID, IntAct17342744 details
MMERUVBL1BioGRID, IntAct17342744 details
MMEMRPL44BioGRID, IntAct17342744 details
MMEUTRNBioGRID, IntAct17342744 details
MMERUVBL2BioGRID, IntAct17342744 details
MMEPOTEHIntAct17342744 details
MMESLC9A3R1BioGRID, IntAct17342744 details
MMECPSF6BioGRID, IntAct17342744 details
MMESDF4BioGRID, IntAct17342744 details
MMERPS10BioGRID, IntAct17342744 details
MMEGUCD1MINT23289620 details
MMECD81MINT23289620 details
MMEDAAM1MINT23289620 details
MMECMSS1MINT23289620 details
MMEHLA-DRB1MINT23289620 details
MMEHLA-AIntAct, MINT23289620 28514442 details
MMENOP9MINT23289620 details
MMEIGLL1MINT23289620 details
MMEANXA6MINT23289620 details
MMESLX9MINT23289620 details
MMEHDAC8BioGRID, IntAct23752268 details
MMEARBioGRID, IntAct23518348 32814769 details
MMEPXMP2BioGRID, IntAct28514442 details
MMEPAM16BioGRID, IntAct28514442 details
MMELEMD3BioGRID, IntAct28514442 details
MMETENM3BioGRID, IntAct28514442 details
MMEGLT8D2BioGRID, IntAct28514442 details
MMEPRXL2ABioGRID, IntAct28514442 details
MMESLC22A18BioGRID, IntAct28514442 details
MMEPOMGNT1BioGRID, IntAct28514442 details
MMELEMD2BioGRID, IntAct28514442 details
MMEPLD6BioGRID, IntAct28514442 details
MMEGALNT7BioGRID, IntAct28514442 details
MMEMANEALBioGRID, IntAct28514442 details
MMEMANEABioGRID, IntAct28514442 details
MMESTARD3BioGRID, IntAct28514442 details
MMESLC10A7BioGRID, IntAct28514442 details
MMEEPHB4BioGRID, IntAct28514442 details
MMEB4GALT1BioGRID, IntAct28514442 details
MMEACSL4BioGRID, IntAct28514442 details
MMETMEM223BioGRID, IntAct28514442 details
MMECD177UniProt21193407 details
MMETEX101BioGRID, UniProt30097533 details
MMECD4BioGRID15047060 details
MMEPOTEIBioGRID17342744 details
MMERGPD6BioGRID17342744 details
MMEESR2BioGRID29509190 details
MMEHADHBBioGRID31536960 details
MMECYB5R3BioGRID31536960 details
MMEDNAJC11BioGRID31536960 details
MMEEMC1BioGRID27342126 details
MMEEMC2BioGRID27342126 details
MMEEMC4BioGRID27342126 details
MMEMMGT1BioGRID27342126 details
MMEANLNBioGRID31586073 details
MMEECT2BioGRID31586073 details
MMEKIF14BioGRID31586073 details
MMEKIF23BioGRID31586073 details
MMENCOR1IntAct23518348 details
MMESIAH2IntAct23518348 details
MMEHNRNPLBioGRID28611215 details