Entity Details

Primary name NF2L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16236
EntryNameNF2L2_HUMAN
FullNameNuclear factor erythroid 2-related factor 2
TaxID9606
Evidenceevidence at protein level
Length605
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesNFE2L2

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0007568 aging
GO:0010226 response to lithium ion
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010628 positive regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0019904 protein domain specific binding
GO:0030194 positive regulation of blood coagulation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032993 protein-DNA complex
GO:0034599 cellular response to oxidative stress
GO:0035690 cellular response to drug
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043565 sequence-specific DNA binding
GO:0045454 cell redox homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0046223 aflatoxin catabolic process
GO:0046326 positive regulation of glucose import
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070301 cellular response to hydrogen peroxide
GO:0071280 cellular response to copper ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:1902037 negative regulation of hematopoietic stem cell differentiation
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903788 positive regulation of glutathione biosynthetic process
GO:1904385 cellular response to angiotensin
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:2000121 regulation of removal of superoxide radicals
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004826 Basic leucine zipper domain, Maf-typeDomainDomain
IPR004827 Basic-leucine zipper domainDomainDomain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR029845 Nuclear factor erythroid 2-related factor 2FamilyFamily

Diseases

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Interactions

132 interactions

InteractorPartnerSourcesPublicationsLink
NF2L2_HUMANKEAP1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11439354 11909699 12145307 14517290 14585973 15475350 15572695 15601839 15985429 16006525 16449638 16790436 16888629 17015834 17462537 17822677 18387606 18417180 18757741 18981988 19706542 20027226 20421418 20463144 20484052 20486933 20599909 21262351 21383067 21988832 22215675 22245129 22302998 22331464 22558124 23066931 23382044 23645672 23722832 23727018 23857982 23986495 24011591 24130096 24322982 24512214 24704364 24844779 25582950 25628777 26078718 26536456 27091842 27212020 27621311 28186440 28416489 28533375 28534518 28617433 28638054 28939422 29033244 29255090 29423025 29792731 30122040 30126895 30383469 30465941 30473361 30576774 30692632 30765703 30778200 30793592 31169361 31257023 31262713 31541481 31695040 31891690 32057361 32159343 32206121 32605589 32854194 32911434 9887101 details
NF2L2_HUMANMAFK_HUMANBioGRID, HPRD, IntAct10747902 11013233 21988832 23737527 32296183 32911434 9150357 details
NF2L2_HUMANTEF_HUMANIntAct32911434 details
NF2L2_HUMANAPEX1_HUMANIntAct32911434 details
NF2L2_HUMANCSN7A_HUMANBioGRID, HPRD, IntAct12020345 32911434 details
NF2L2_HUMANNFE2_HUMANBioGRID, HPRD, UniProt12805554 23661758 details
NF2L2_HUMANMAFG_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11013233 18692475 21988832 22942279 23661758 23737527 24140708 25416956 32296183 32911434 9150357 details
NF2L2_HUMANSP140_HUMANIntAct32911434 details
NF2L2_HUMANPMF1_HUMANBioGRID, HPRD, IntAct10419538 11256947 12020345 32911434 details
NF2L2_HUMANDCA11_HUMANBioGRID28453520 details
NF2L2_HUMANIMA4_HUMANBioGRID, IntAct21988832 details
NF2L2_HUMANMAFF_HUMANBioGRID, HPRD, IntAct, UniProt12490281 23661758 23737527 26186194 28514442 32911434 details
NF2L2_HUMANATF4_HUMANBioGRID, HPRD, IntAct, UniProt11274184 23661758 26700459 32911434 details
NF2L2_HUMANELK1_HUMANIntAct32911434 details
NF2L2_HUMANCBP_HUMANBioGRID, HPRD11683914 18241676 19273602 details
NF2L2_HUMANNCOR2_HUMANBioGRID15870285 details
NF2L2_HUMANBPTF_HUMANBioGRID15379550 details
NF2L2_HUMANNFAT5_HUMANIntAct32911434 details
NF2L2_HUMANMP2K6_HUMANIntAct32911434 details
NF2L2_HUMANTIF1A_HUMANBioGRID, IntAct20211142 details
NF2L2_HUMANGSK3B_HUMANBioGRID22751928 details
NF2L2_HUMANENC1_HUMANBioGRID17875699 18981988 20511222 details
NF2L2_HUMANSUMO1_HUMANBioGRID23543742 details
NF2L2_HUMANFOSB_HUMANIntAct32911434 details
NF2L2_HUMANCASP3_HUMANHPRD10510468 details
NF2L2_HUMANKDM1A_HUMANBioGRID, IntAct32296183 details
NF2L2_HUMANARFP2_HUMANIntAct32911434 details
NF2L2_HUMANCASP7_HUMANIntAct32911434 details
NF2L2_HUMANLEF1_HUMANIntAct32911434 details
NF2L2_HUMANSPIC_HUMANIntAct32911434 details
NF2L2_HUMANREL_HUMANIntAct32911434 details
NF2L2_HUMANIRF2_HUMANIntAct32911434 details
NF2L2_HUMANSMAD1_HUMANIntAct32911434 details
NF2L2_HUMANE2AK3_HUMANBioGRID, HPRD14517290 details
NF2L2_HUMANRBMX_HUMANBioGRID, IntAct21988832 details
NF2L2_HUMANZHANG_HUMANIntAct32911434 details
NF2L2_HUMANSUMO2_HUMANBioGRID23543742 details
NF2L2_HUMANMK08_HUMANBioGRID24704364 31945188 details
NF2L2_HUMANSTAT3_HUMANIntAct32911434 details
NF2L2_HUMANZBT24_HUMANIntAct32911434 details
NF2L2_HUMANCF299_HUMANIntAct32911434 details
NF2L2_HUMANUB2E2_HUMANBioGRID20484052 details
NF2L2_HUMANCEBPG_HUMANIntAct32911434 details
NF2L2_HUMANATF3_HUMANIntAct32911434 details
NF2L2_HUMANELF4_HUMANIntAct32911434 details
NF2L2_HUMANWAC_HUMANBioGRID, IntAct25416956 31515488 details
NF2L2_HUMANIRF1_HUMANIntAct32911434 details
NF2L2_HUMANJUN_HUMANBioGRID, HPRD, IntAct12805554 20194533 20232342 32911434 9872330 details
NF2L2_HUMANTNNT1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
NF2L2_HUMANATM_HUMANIntAct32911434 details
NF2L2_HUMANCHD6_HUMANHPRD16314513 details
NF2L2_HUMANFOSL2_HUMANIntAct32911434 details
NF2L2_HUMANELF1_HUMANIntAct32911434 details
NF2L2_HUMANETV1_HUMANIntAct32911434 details
NF2L2_HUMANTF65_HUMANIntAct32911434 details
NF2L2_HUMANTBP_HUMANIntAct32911434 details
NF2L2_HUMANCADH1_HUMANBioGRID22302998 details
NF2L2_HUMANHNRPR_HUMANIntAct32911434 details
NF2L2_HUMANELF5_HUMANIntAct32911434 details
NF2L2_HUMANTAD2A_HUMANIntAct32911434 details
NF2L2_HUMANBRPF3_HUMANIntAct32911434 details
NF2L2_HUMANIMA1_HUMANIntAct32911434 details
NF2L2_HUMANNF2L3_HUMANBioGRID, UniProt23661758 details
NF2L2_HUMANZN396_HUMANIntAct32911434 details
NF2L2_HUMANARPC2_HUMANIntAct32911434 details
NF2L2_HUMANIMA3_HUMANIntAct32911434 details
NF2L2_HUMANCREB3_HUMANBioGRID, UniProt23661758 details
NF2L2_HUMANETS2_HUMANIntAct32911434 details
NF2L2_HUMANEIF3J_HUMANIntAct32911434 details
NF2L2_HUMANDDIT3_HUMANIntAct32911434 details
NF2L2_HUMANMK07_HUMANBioGRID23043106 details
NF2L2_HUMANKPCA_HUMANBioGRID12947090 details
NF2L2_HUMANELF3_HUMANIntAct32911434 details
NF2L2_HUMANETV4_HUMANIntAct32911434 details
NF2L2_HUMANGATA1_HUMANIntAct32911434 details
NF2L2_HUMANCASP1_HUMANBioGRID, HPRD10510468 28247911 details
NF2L2_HUMANPAQR4_HUMANBioGRID32206121 details
NF2L2_HUMANCERS2_HUMANIntAct32911434 details
NF2L2_HUMANCRBL2_HUMANIntAct32911434 details
NF2L2_HUMANBRPF1_HUMANIntAct32911434 details
NF2L2_HUMANGRB2_HUMANIntAct32911434 details
NF2L2_HUMANETV6_HUMANIntAct32911434 details
NF2L2_HUMANUB2E3_HUMANBioGRID20484052 details
NF2L2_HUMANNCOR1_HUMANBioGRID15870285 details
NF2L2_HUMANMP2K1_HUMANBioGRID24704364 details
NF2L2_HUMANHDAC1_HUMANBioGRID22308472 details
NF2L2_HUMANDCAF1_HUMANBioGRID32171724 details
NF2L2_HUMANRNF4_HUMANBioGRID23543742 details
NF2L2_HUMANHDAC3_HUMANBioGRID22308472 details
NF2L2_HUMANLMNA_HUMANBioGRID31687081 details
NF2L2_HUMANFBW1B_HUMANBioGRID, IntAct25332235 25515538 32911434 details
NF2L2_HUMANUSP9X_HUMANBioGRID32442538 details
NF2L2_HUMANSQSTM_HUMANBioGRID, IntAct20421418 20452972 details
NF2L2_HUMANTYY1_HUMANBioGRID20309604 details
NF2L2_HUMANPGAM5_HUMANBioGRID18387606 details
NF2L2_HUMANBRCA1_HUMANBioGRID23857982 details
NF2L2_HUMANH31_HUMANBioGRID31687081 details
NF2L2_HUMANACTB_HUMANBioGRID32416241 details
NF2L2_HUMANERR2_HUMANIntAct17920186 details
NF2L2_HUMANRBM45_HUMANBioGRID25939382 details
NF2L2_HUMANPPARG_HUMANHPRD10930400 details
NF2L2_HUMANCUL3_HUMANBioGRID15367669 15601839 details
NF2L2_HUMANG45IP_HUMANBioGRID20427290 details
NF2L2_HUMANAKT1_HUMANBioGRID24704364 details
NF2L2_HUMANTBB5_HUMANBioGRID32416241 details
NF2L2_HUMANKPCD_HUMANHPRD12198130 details
NF2L2_HUMANEF1G_HUMANMINT21597468 details
NF2L2_HUMANU17L2_HUMANBioGRID30778200 details
NF2L2_HUMANFBW1A_HUMANBioGRID, IntAct25900982 26091241 31220549 32911434 details
NF2L2_HUMANIASPP_HUMANBioGRID29033244 details
NF2L2_HUMANHDAC2_HUMANBioGRID22308472 details
NF2L2_HUMANRN111_HUMANBioGRID29597191 details
NF2L2_HUMANSMCA4_HUMANBioGRID16923960 details
NF2L2_HUMANAHR_HUMANBioGRID20395535 details
NF2L2_HUMANPAQR3_HUMANBioGRID27212020 details
NF2L2_HUMANMYC_HUMANBioGRID20232342 22942279 details
NF2L2_HUMANMP2K2_HUMANBioGRID24704364 details
NF2L2_HUMANSIAH2_HUMANBioGRID23645672 details
NF2L2_HUMANMK09_HUMANBioGRID24704364 details
NF2L2_HUMANMAF_HUMANBioGRID26078718 details
NF2L2_HUMANNCF1_HUMANBioGRID28939422 details
NF2L2_HUMANBACH1_HUMANBioGRID15734732 details
NF2L2_HUMANNQO1_HUMANBioGRID24140708 details
NF2L2_HUMANRARA_HUMANDIP18048326 details
NF2L2_HUMANPML_HUMANMINT28777872 details
NF2L2_HUMANTIF1B_HUMANBioGRID25995248 details
NF2L2_HUMANJUND_HUMANHPRD9872330 details
NF2L2_HUMANEP300_HUMANBioGRID32057361 details
NF2L2_HUMANCDN1A_HUMANBioGRID19560419 details
NF2L2_HUMANUBC_HUMANBioGRID25742418 details
NF2L2_HUMANDUS1_HUMANBioGRID31811110 details
NF2L2_HUMANTCF20_HUMANBioGRID24416372 details